Cardiask pills 50mg №30

Active ingredient

white color, round, biconvex, with a smooth shiny surface, light roughness is allowed.

1 pill contains Acetylsalicylic acid 50 mg or 100 mg;
Excipients: corn starch, lactose, microcrystalline cellulose, Plasdon K-90, Calcium stearate, Tween-80, MAKE 100 Collicut, Plasdone S-630, propylene glycol, talc, castor oil, titanium dioxide.
10, 20 or 30 pills per pack.

Mechanism of action

- NSAID antiagregant. The main mechanism of action of the drug CardiAc is irreversible inactivation of the enzyme cyclooxygenase (COX-1), as a result of which the synthesis of thromboxane A2 is blocked and platelet aggregation is inhibited. CardiASK also has anti-inflammatory, antipyretic and analgesic effects.

Indications and usage

• Prevention of acute myocardial infarction in the presence of risk factors (including diabetes, hyperlipidemia, arterial hypertension, obesity, smoking, old age) and repeated myocardial infarction;
• Unstable Angina;
• Stroke prevention (including in patients with transient disorders of cerebral circulation);
• Prevention of transient disorders of cerebral circulation;
• Prevention of thromboembolism after operations and invasive interventions on the vessels (including coronary artery bypass surgery, carotid artery endarterectomy, arteriovenous bypass surgery, carotid artery angioplasty);
• Prevention of deep vein thrombosis and thromboembolism of the pulmonary artery and its branches (including with prolonged immobilization as a result of extensive surgical intervention).

• Hypersensitivity to acetylsalicylic acid and other NSAIDs;
• erosive and ulcerative lesions of the digestive tract;
• gastrointestinal bleeding;
• bronchial asthma induced by salicylates and NSAIDs;
• the "aspirin triad" (Fernan-Vidal triad: a combination of bronchial asthma, recurrent nasal polyposis and paranasal sinuses and intolerance to acetylsalicylic acid);
• hemorrhagic diathesis;
• combined use with Methotrexate at a dose of 15 mg per week or more;
• liver failure;
• renal failure;
• I and III trimester of pregnancy;
• lactation (breastfeeding);
• age up to 18 years.

WITH caution: prescribed for gout, hyperuricemia, as well as patients with a history of indications of ulcerative lesions of the gastrointestinal tract or Gastrointestinal bleeding, bronchial asthma, chronic diseases of the respiratory system, hay fever, polyposis of the nasal mucosa, allergic reactions to drugs, when used together with methotrexate in doses of less than 15 mg per week, with a deficiency of vitamin K and glucose-6-phosphate dehydrogenase.

Dosage and administration

CardiASK should be taken orally, before meals with plenty of fluids.
CardiASK is designed for long-term use. The duration of therapy is determined by the attending physician.

Prevention for suspected acute myocardial infarction: 100-200 mg / day or 300 mg every other day (the first pill should be chewed for faster absorption).
Prevention of newly emerged acute myocardial infarction in the presence of risk factors: 100 mg per day or 300 mg every other day.
Prevention of recurrent myocardial infarction, unstable stenocardia, prevention of stroke and transient cerebral circulation, prevention of thromboembolic complications after surgery or invasive studies: 100-300 mg per day
Prevention of deep vein thrombosis and pulmonary thromboembolism and its branches: 100-200 mg per day or 300 mg every other day.

Allergic reactions: urticaria, angioedema.
From the digestive tract: nausea, heartburn, vomiting, pain in the abdomen, ulcers of the mucous membrane of the stomach and duodenum, including perforative, gastrointestinal bleeding, increased activity of "liver" enzymes.
On the part of the respiratory system: bronchospasm.
On the part of the immune system: anaphylactic reactions.
From the hemopoietic system: anemia (rare), increased bleeding.
From the side of the central nervous system: dizziness, tinnitus.

Overdosage

Symptoms of a moderate severity overdose: nausea, vomiting, tinnitus, hearing loss, dizziness, confusion.
Treatment: reduced dose of the drug.

Symptoms of severe overdose:
fever, hyperventilation, ketoacidosis, respiratory alkalosis, coma, cardiovascular and respiratory failure, severe hypoglycemia.
Treatment: immediate hospitalization in specialized departments for emergency treatment - gastric lavage, determination of acid-base state, alkaline and forced alkaline diuresis, hemodialysis, administration of solutions, Activated carbon, symptomatic therapy. When conducting alkaline diuresis, it is necessary to achieve pH values ​​between 7.5 and 8. Forced alkaline diuresis should be performed when the concentration of salicylates in the blood plasma is more than 500 mg / l (3.6 mmol / l) in adults and 300 mg / l (2, 2 mmol / l) in children.

When combined, CardiASK enhances the effects of methotrexate by reducing its renal clearance and displacement of plasma blood proteins.
With simultaneous use CardiASK enhances the effect of Heparin and indirect anticoagulants due to dysfunction of platelets and the displacement of indirect anticoagulants from bonds with plasma proteins.
CardiASK with combined use enhances the action of thrombolytic and antiplatelet drugs (including ticlopidine).
CardiASK increases the concentration of Digoxin in the blood plasma by reducing renal excretion and enhances its effects.
CardiASK enhances the action of hypoglycemic drugs (insulin and sulfonylurea derivatives) due to the hypoglycemic effect of acetylsalicylic acid (in high doses) and the removal of sulfonylurea derivatives from the association with plasma proteins.
CardiASK enhances the action of valproic acid by displacing the latter from binding to plasma proteins.
When combined, CardiASK reduces the effect of uricosuric drugs (benzbromarone) due to competitive tubular elimination of uric acid.
With simultaneous use of GCS enhance the excretion of salicylates and weakens their effect.
When used simultaneously with ethanol, an additive effect is noted.

Special notes

The use of the drug CardiAAS can provoke bronchospasm and attacks of bronchial asthma and other hypersensitivity reactions. Risk factors include a history of bronchial asthma, hay fever, polyposis of the nasal mucosa, chronic diseases of the respiratory tract, allergic reactions to other drugs (including skin reactions, itching, urticaria).
The drug can cause bleeding of varying severity during and after surgery.
Combined use of CardiASK with anticoagulants, thrombolytics, antiplatelet drugs is associated with an increased risk of bleeding.
Low-dose cardiAASK can trigger the development of gout in susceptible patients (with reduced uric acid excretion).
The combined use of CardiASK and methotrexate is accompanied by an increased incidence of side effects from the blood-forming organs.
The use of CardiAASK in high doses may have a hypoglycemic effect, which must be considered when prescribing the drug to diabetics who receive hypoglycemic therapy.
With the combined use of GCS and salicylates, it should be remembered that during treatment, the level of salicylates in the blood is reduced, and after GCS is canceled, an overdose of salicylates may develop.
The combined use of CardiASK with Ibuprofen is not recommended.
The use of CardiAASK in high doses is associated with the risk of gastrointestinal bleeding.
When used while taking the drug alcohol increases the risk of damage to the gastrointestinal mucosa and lengthening the bleeding time.

In a dry, dark place at a temperature not higher than 25 ° C. Keep out of reach of children.

- 2 years. Do not use the drug after the expiration date printed on the package.