Thrombotic ass pills 50mg №28

Mechanism of action

NSAIDs. The basis of the mechanism of action of Acetylsalicylic acid (ASA) is irreversible inhibition of cyclooxygenase, which results in the synthesis of thromboxane A2 being blocked and platelet aggregation is inhibited. It is believed that there are other mechanisms for the suppression of platelet aggregation, which expands its field of application in various vascular diseases.

It also has anti-inflammatory, analgesic and antipyretic effect.

Pharmacokinetics

Suction

After taking the drug inside acetylsalicylic acid is absorbed from the upper section of the small intestine. Cmax in plasma is noted on average 3 hours after taking the drug.

Metabolism

Acetylsalicylic acid undergoes partial metabolism in the liver to form less active metabolites.

Removal

It is excreted by the kidneys both unchanged and in the form of metabolites. T1 / 2 for ASA is about 15 minutes, for metabolites - about 3 hours.

Indications for use of the drug

- prevention of acute myocardial infarction in the presence of risk factors (such as diabetes, hyperlipidemia, arterial hypertension, obesity, smoking, old age);

- secondary prevention of myocardial infarction;

- unstable angina;

- prevention of stroke (including in patients with transient disorders of cerebral circulation);

- prevention of transient disorders of cerebral circulation;

- prevention of thromboembolism after operations and invasive interventions on vessels (such as aorto-coronary bypass surgery, carotid artery endarterectomy, arterio-venous bypass surgery, carotid angioplasty);

- prevention of deep vein thrombosis and pulmonary thromboembolism and its branches (for example, during prolonged immobilization as a result of serious surgical intervention).

Dosage and administration

Tablets should be taken orally, without chewing, before meals, washed down with a small amount of liquid.

Assign inside 50 -100 mg 1 time /

Thrombo ACC&№174; is intended for long-term use. The duration of therapy is determined individually.

Side effects

Allergic reactions: urticaria, angioedema, Anaphylactic reactions.

On the part of the digestive system: nausea, heartburn, vomiting, abdominal pain, ulcers of the mucous membrane of the stomach and duodenum (including perforative), increased activity of liver enzymes.

On the part of the respiratory system: bronchospasm.

On the part of the blood system: anemia (rare), increased bleeding.

From the side of the central nervous system: dizziness, tinnitus.

In general, Thrombotic ACC&№174; is well tolerated by patients (due to the low content of acetylsalicylic acid in the preparation). Side effects are noted in some cases.

Contraindications

- erosive and ulcerative lesions of the gastrointestinal tract, Gastrointestinal bleeding;

- "Aspirin" asthma (bronchial asthma, induced by the intake of salicylates and NSAIDs);

- "Aspirin Triad" (a combination of bronchial asthma, recurrent polyposis of the nose and paranasal sinuses and intolerance to acetylsalicylic acid);

- hemorrhagic diathesis;

- combined use with Methotrexate at a dose of 15 mg or more per week;

- I and III trimesters of pregnancy;

- lactation (breastfeeding);

- children's and teenage age up to 18 years;

- Hypersensitivity to acetylsalicylic acid, to excipients of the drug and other NSAIDs.

With caution prescribed for gout, hyperuricemia, ulcerative lesions of the gastrointestinal tract or bleeding from the gastrointestinal tract in history, with renal and hepatic insufficiency, bronchial asthma, chronic respiratory diseases, with hay fever, nasal polyposis, with allergic reactions to drugs in history, with simultaneous use with methotrexate at a dose of 15 mg or less per week.

Use during pregnancy and lactation

The use of large doses of salicylates in the first 3 months of pregnancy is associated with an increased frequency of defects in fetal development (split palate, heart defects). In the second trimester of pregnancy, salicylates can only be prescribed with a rigorous assessment of risk and benefit. The appointment of ASC in the last trimester is contraindicated.

Salicylates and their metabolites in small doses pass into breast milk. Prolonged use of salicylates is a reason to stop breastfeeding. Accidental intake of salicylates during lactation is not accompanied by the development of adverse reactions in the child and does not require discontinuation of breastfeeding.

Special notes

ASK can provoke bronchospasm, as well as cause attacks of asthma and other hypersensitivity reactions.Risk factors are a history of bronchial asthma, hay fever, nasal polyposis, chronic respiratory diseases, and allergic reactions to other drugs (pruritus, urticaria).

ASK can cause bleeding of varying severity during and after surgery.

The combination of ASA with anticoagulants, thrombolytic agents, antiplatelet agents is accompanied by an increased risk of bleeding.

ASC in low doses can trigger the development of gout in susceptible individuals with reduced uric acid excretion.

The combination of ASA with methotrexate is accompanied by an increased incidence of side effects from the hematopoietic system.

High doses of ASA have a hypoglycemic effect, which must be considered when prescribing it to patients with diabetes who are receiving hypoglycemic drugs.

When combined with the appointment of corticosteroids should be remembered that during treatment the level of salicylates in the blood is reduced, and after the abolition of corticosteroids possible overdose of salicylates.

The combination of ASA with Ibuprofen is not recommended, since the latter worsens the beneficial effect of ASA on life expectancy.

When combined ASA with alcohol increased the risk of damage to the gastrointestinal mucosa and lengthening the time of bleeding.

Overdosage

Overdose is unlikely due to the low content of ASA in the drug. Excess doses of ASA are associated with the risk of gastrointestinal bleeding. Overdose is especially dangerous in elderly patients.

Symptoms: nausea, vomiting, tinnitus, dizziness, confusion, general malaise.

Treatment: artificial vomiting, the appointment of Activated carbon, laxatives; if necessary, carry out the correction of acid-base balance.

Drug interaction

With simultaneous use of Thrombotic ACC ® enhances the effect of the following drugs:

- methotrexate by reducing renal clearance and pushing it out of communication with proteins;

- Heparin and indirect anticoagulants due to dysfunction of platelets and the displacement of indirect anticoagulants from binding to proteins;

- thrombolytic and antiplatelet agents (ticlopidine);

- Digoxin due to a decrease in its renal excretion;

- hypoglycemic agents (insulin and sulfonylurea derivatives) due to the hypoglycemic properties of ASA itself in high doses and forcing out sulfonylurea derivatives from bonds with proteins;

- valproic acid due to its displacement from bonds with proteins.

An additive effect is observed while taking ASA with ethanol.

ASA weakens the effect of uricosuric drugs (benzbromarone) due to competitive tubular elimination of uric acid.

With simultaneous use of GCS enhance the excretion of salicylates and weaken their action.

Terms and conditions of storage

List B. The drug should be kept out of the reach of children at a temperature not exceeding 25 ° C.