Anastrozole pills 1 mg №30

Active ingredient

Pharmacotherapeutic group

Antitumor agent, estrogen synthesis inhibitor

Pharmacology

Anastrozole is a highly selective non-steroidal aromatase inhibitor - an enzyme with which, in postmenopausal women, androstenedione in peripheral tissues is converted into estrone and further into estradiol. Reducing circulating concentrations of estradiol has been shown to have a positive effect on women with breast cancer. In postmenopausal women, anastrozole in a daily dose of 1 mg causes a decrease in the estradiol concentration by 80%. Anastrozole does not possess progestogenic, androgenic or estrogenic activity. Regular intake of daily doses of anastrozole up to 10 mg does not affect the secretion of cortisol or aldosterone, therefore, its administration does not require the replacement of corticosteroids.

Indications

Adjuvant therapy for early hormone-positive breast cancer in postmenopausal women; treatment of advanced breast cancer in postmenopausal women; adjuvant therapy for early hormone-positive breast cancer in postmenopausal women after Tamoxifen therapy for 2–3 years.

Contraindications

Hypersensitivity to anastrozole or other components of the drug; pregnancy and lactation period; premenopausal period; severe renal failure (creatinine clearance <20 ml / min); average degree of liver failure; severe degree of liver failure (safety and efficacy not established); concomitant therapy with tamoxifen or estrogen preparations; children's age up to 18 years (safety and efficacy in children have not been established).

Dosage and administration

Inside The pill is swallowed whole with water. It is recommended to take the drug at the same time, regardless of the meal. Adults, including the elderly: 1 mg orally once a day for a long time. If there is evidence of disease progression, the drug should be discontinued. As adjuvant therapy, the recommended duration of treatment is 5 years. Mild and moderate renal failure: dose adjustment in patients with mild to moderate renal impairment is not required. Mild liver failure: dose adjustment in patients with mild liver failure is not required.

Release form

Tablets, film coated 1 mg to 30 pills per pack.

Pharmacy sales terms

On prescription.