Tamoxifen pills 20mg №100

Overdosage

Acute overdose of Tamoxifen was not observed in humans. It should be expected that overdose may cause an increase in the above described adverse reactions. There are no specific antidotes, treatment should be symptomatic.

Drug interactions

With the simultaneous appointment of Tamoxifen and cytostatics increases the risk of thrombus formation.

Antacids, H2-histamine receptor blockers and other drugs of similar action, increasing the pH value in the stomach, can cause premature dissolution and loss of the protective effect of the enteric tablet. The interval between taking tamoxifen and these drugs should be 1-2 hours.There are reports of Tamoxifen enhancing the anticoagulant effect of coumarin preparations (for example, warfarin).

Drugs that reduce Calcium excretion (for example, thiazide diuretics) may increase the risk of hypercalcemia.

The combined use of tamoxifen and tegafur can contribute to the development of active chronic hepatitis and cirrhosis of the liver.

The simultaneous use of Tamoxifen with other hormonal drugs (especially estrogen-containing contraceptives) leads to a weakening of the specific action of both drugs.

Women receiving tamoxifen should undergo regular gynecological examination. When a bloody discharge from the vagina or vaginal bleeding occurs, the drug should be stopped.

In patients with bone metastases, the concentration of calcium in the serum should be determined periodically during the initial period of treatment. In case of marked violations, tamoxifen should be temporarily stopped. If there are signs of venous thrombosis of the lower extremities (pain in the legs or their swelling), pulmonary embolism (shortness of breath), the drug should be stopped.

Tamoxifen can cause ovulation, which increases the risk of pregnancy, and therefore, it is recommended to use a mechanical or non-hormonal contraceptive during tamoxifen treatment for women who have an active sex life.

During the period of therapy, it is necessary to periodically monitor blood coagulation parameters, calcium content in the blood, blood picture (leukocytes, platelets), liver function indicators, blood pressure, to be examined by an ophthalmologist. In patients with hyperlipidemia in the process of treatment it is necessary to control the concentration of cholesterol and TG in the serum.

During the period of treatment, it is necessary to refrain from engaging in potentially hazardous activities that require high concentration of attention and quickness of psychomotor reactions.

Tablets 10 mg and 20 mg.

On 30 or 100 pills in bottles from HDPE with a lid of similar material, with the control of the first opening. On 1 bottle together with the application instruction in a cardboard pack.

Storage conditions

At a temperature of 15 to 25 ° C.

Keep out of the reach of children!