Ketonal cream 5% 50g

Packaging

Aluminum tube 50g. in carton

Mechanism of action

PVA, a derivative of propionic acid. It has an analgesic, anti-inflammatory and antipyretic effect. The mechanism of action is associated with inhibition of prostaglandin synthesis at the level of cyclooxygenase. In addition, Ketoprofen inhibits lipoxygenase, has anti-bradykinin activity, stabilizes lysosomal membranes.

Ketoprofen does not adversely affect the state of the articular cartilage.

Ketoprofen well penetrates into the subcutaneous tissue, ligaments and muscles, synovial fluid and reaches therapeutic concentrations there.

Indications and usage

Symptomatic therapy:

- rheumatoid arthritis and periarthritis;

- ankylosing spondylitis (ankylosing spondylitis);

- psoriatic arthritis;

- reactive arthritis (Reiter's syndrome);

- osteoarthritis of different localization;

- tendinitis, bursitis;

- myalgia;

- neuralgia;

- sciatica;

- injuries of the musculoskeletal system (including sports), injuries of muscles and ligaments, sprains, torn ligaments and tendons of muscles.

Contraindications

- skin damage or skin disease at the site of application of the drug (eczema, oozing dermatitis, open or infected wound);

- III trimester of pregnancy;

- children's age up to 12 years;

- hypersensitivity to ketoprofen, Acetylsalicylic acid or other NSAIDs;

- indications of a history of bronchospasm, urticaria and rhinitis caused by taking NSAIDs and salicylates.

With caution should be prescribed the drug in violation of the liver and / or kidneys, erosive and ulcerative lesions of the gastrointestinal tract, blood diseases, bronchial asthma, chronic heart failure.

Pregnancy and Breastfeeding

The drug is contraindicated for use in the third trimester of pregnancy.

Application in the I and II trimesters is possible in cases where the expected benefit of therapy for the mother outweighs the potential risk to the fetus.

Ketonal should not be used during lactation (breastfeeding).

Dosage and administration

A small amount of cream (3-5 cm) is applied with a thin layer on the skin above the lesion 2-3 times / day, slightly rubbing. Duration of treatment - 14 days or more (after consulting a doctor).

Cautions

When using Ketonal, avoid contact with the mucous membranes and eyes.

If side effects occur, discontinue use of the drug.

During therapy, direct sunlight and ultraviolet radiation should be avoided.

The cream can be used in combination with other forms of the drug Ketonal (capsules, tablets, suppositories). The total dose, regardless of the medicinal dose should not exceed 300 mg.

If the patient has forgotten to apply the cream, he should use it at the time when it is necessary to apply the next dose, but not double it.

Influence on ability to drive motor vehicles and control mechanisms: no data.

Drug Interactions

The simultaneous use of other topical forms (ointments, gels) containing ketoprofen or other NSAIDs is not recommended.

Simultaneous administration of acetylsalicylic acid reduces ketoprofen binding to plasma proteins.

Ketoprofen reduces the excretion of Methotrexate and increases its toxicity.

Interactions with other drugs and the effect on their elimination are not significant.

Overdosage

Symptoms: irritation, erythema, itching.

Treatment: it is necessary to cancel the drug. Symptomatic therapy is performed.

Storage conditions

The drug should be stored out of the reach of children at a temperature not higher than 25 ° C.