Calcemin Advance Coated pill №120

Active ingredient and dosage form

coated tablets pink color, elongated capsule-shaped, with a notch extruded on one side.
Active substances: calcium (calcium citrate and Calcium carbonate) 500 mg, colecalciferol (vitamin D3) 200 IU, Magnesium 40 mg, zinc 7.5 mg, copper 1 mg, manganese 1.8 mg, boron 250 μg.
Excipients: maltodextrin, microcrystalline cellulose, sodium croscarmellose, acacia, stearic acid, soy polysaccharide, titanium dioxide, sodium lauryl sulfate.
on 30; 60; 120 pills per pack.

Mechanism of action

Kalzemin Advance - mineral and vitamin complex. Regulates phosphorus-calcium metabolism. Fills the deficit of calcium, vitamin D3, magnesium, trace elements. It helps strengthen bones and joints, prevents diseases of the musculoskeletal system.

Calcium, which is part of the preparation, is a building component for bone tissue, regulates vascular wall permeability, participates in the regulation of conductivity in synapses and neuro-muscular compounds, participates in the contractile activity of skeletal and smooth muscles, is a necessary component for the blood coagulation process. Calcium is represented in the preparation of carbonate and citrate salts. Calcium carbonate contains the maximum amount of elemental calcium. Calcium citrate reduces the dependence of the process of calcium bioavailability on the state of the mucous membrane of the gastrointestinal tract, prevents concretion in the urinary system, even in the case of prolonged use, reduces the excess production of parathyroid hormone.

Vitamin D (cholecalciferol) contributes to the adequate absorption of calcium, is involved in the processes of regeneration and building bone tissue.
Zinc is a component of various body enzymes (more than 200 types) that synthesize proteins and nucleic acids. It also provides gene expression, regeneration and cell growth. A positive effect on the activity of the enzyme alkaline phosphatase.
Manganese promotes the synthesis of substances that are components of bone and cartilage tissue (glycosaminoglycans). Potentiates calcium-sparing ability of vitamin D.
Copper is involved in the formation of elastin, collagen. It helps to stop the phenomenon of demineralization of bone structures.
Boron normalizes the activity of parathyroid hormone - parathyroid hormone. The latter is involved in the metabolism of calcium, cholecalciferol, phosphorus, magnesium. The effect on mineral metabolism of parathyroid hormone does not depend on the intake of vitamin D3.
Calcium is absorbed from the gastrointestinal tract, is eliminated from the body with urine, sweat and feces. Calcium absorption is possible due to the activity of calbindin, an enzyme of the intestinal mucosa. Kalbindin biosynthesis directly depends on calcitriol, a vitamin D metabolite.
Vitamin D is rapidly absorbed from the intestines. It penetrates into the bones, liver, adrenal glands, adipose tissue, heart muscle. With the release of vitamin D with bile, its reabsorption is observed. Partially transformed into inactive metabolites.
Zinc is eliminated by the kidneys (10%) and intestines (90%).
Copper is absorbed from the intestine partially, the rest is eliminated unchanged or in the form of insoluble complexes. 80% of the injected copper is excreted in the bile, 16% in the intestines, 4% in the kidneys, a very small amount in the sweat glands.
Boron after absorption from the intestine is excreted by the kidneys (90%).

Indications and usage

Prevention and complex treatment of osteoporosis of various origins:
- in women during menopause (natural and surgical);
- in individuals who take SCS and immunosuppressants for a long time.
Therapy of diseases of the musculoskeletal system (to improve the consolidation of traumatic fractures)
To compensate for calcium deficiency and trace elements in adolescents.

Dosage and administration

Calcemin Advance pills are taken with meals.

Adults and children (over 12 years old) - 1 pill 2 times a day.

At calcium deficiency and trace elements appoint 1 pill per day.

Adverse reactions

From the digestive system: nausea, vomiting, flatulence.
Metabolism: hypercalcemia and hypercalciuria.
Other: allergic reactions.

Contraindications

–– increased sensitivity to the drug’s components,
- children's age up to 12 years;
- hypercalciuria,
- hypercalcemia,
- urolithiasis disease;

Special notes

Do not exceed the recommended dose, because Increased calcium intake may inhibit intestinal absorption of iron, zinc, and other essential minerals.

Storage conditions

Store in a dry place out of reach of children at a temperature of 15 ° to 30 ° C.