Cycloferon ampoules 12.5% ​​2 ml №5

Dosage form

Solution for in / in and in / m introduction

Composition

1 ampoule (2 ml) contains acridone acetic acid (in the form of meglumine acridone acetate) 250 mg;
Excipients: water d / and.

Packing

5 pieces.

Mechanism of action

Cycloferon - Antiviral and immunomodulatory drugs. Interferon synthesis inductor.

The main cells producing interferon after administration of Cycloferon are macrophages, T-lymphocytes, B-lymphocytes, fibroblasts, epithelial cells. Depending on the type of infection, activation of one or another immunity link takes place. The drug induces high titers of interferon in organs and tissues containing lymphoid elements (spleen, liver, lungs), activates bone marrow stem cells, stimulating the formation of granulocytes. Cycloferon activates T-lymphocytes and natural killer cells, normalizes the balance between T-helper and T-suppressor subpopulations. Overcomes the blood-brain barrier.

Cycloferon is effective against tick-borne encephalitis, influenza, hepatitis, herpes, cytomegalovirus, human immunodeficiency virus, papillomavirus and other viruses.

The high efficacy of the drug in the complex treatment of acute and chronic bacterial infections (chlamydia, erysipelas, bronchitis, pneumonia,postoperative complications, bacterial and fungal infections of the urogenital area, peptic ulcer) as a component of immunotherapy.

Cycloferon exhibits high efficacy in rheumatic and systemic diseases of the connective tissue, suppressing autoimmune reactions and exerting an anti-inflammatory and analgesic effect.

The immunomodulating effect of cycloferon is expressed in the activation of phagocytosis, natural killer cells, cytotoxic T-lymphocytes and the correction of the immune status of the organism in immunodeficient and autoimmune states of various origin.

Indications and usage

As part of complex therapy in adults: 
- HIV infection (stages 2A-2B);
- neuroinfections: serous meningitis and encephalitis, tick-borne borreliosis (Lyme disease);
- viral hepatitis A, B, C, D;
- herpes infection;
- cytomegalovirus infection;
- secondary immunodeficiencies associated with acute and chronic bacterial and fungal infections;
- Chlamydia infections;
- rheumatic and systemic diseases of connective tissue (rheumatoid arthritis, systemic lupus erythematosus);
- degenerative-dystrophic diseases of the joints (including deforming osteoarthritis).

As part of complex therapy in children: 
-viral hepatitis A, B, C, D;
- herpes infection;
- HIV infection (stage 2A-2B).

Contraindications

Pregnancy, lactation period, children up to 4 years old, individual intolerance to the components of the drug, decompensated cirrhosis of the liver.

Pregnancy and Breastfeeding

Contraindicated.

Dosage and administration

Cycloferon is administered intramuscularly or intravenously in 1 time per day according to the basic scheme: every other day. The duration of treatment depends on the disease.

For herpes and cytomegalovirus infections the drug is prescribed according to the basic scheme - 10 injections of 250 mg each. The total dose of 2.5 g. Treatment is most effective at the beginning of the exacerbation of the disease.

With neuroinfections the drug is administered according to the basic scheme. The course of treatment is 12 injections of 250-500 mg in combination with etiotropic therapy. The total dose of 3-6 g. Repeated courses are carried out as needed.

For chlamydial infection treatment is carried out according to the basic scheme. The course of treatment 10 injections of 250 mg. The total dose of 2.5 g. Repeated course - in 10-14 days. It is advisable combination of cycloferon with antibiotics.

In acute viral hepatitis A, B, C, D and mixed forms the drug is administered according to the basic scheme of 10 injections of 500 mg. The total dose is 5 g. With a protracted course, a repeated course is carried out in 10-14 days.

In chronic viral hepatitis B, C, D and mixed forms the drug is administered according to the basic scheme of 10 injections of 500 mg, then under the supporting scheme 3 times a week. within 3 months as part of complex therapy. Recommended in combination with interferons and Chemotherapy. Repetition of the course is carried out in 10-14 days.

With HIV infection (stage 2A-2B) the drug is prescribed according to the basic scheme of 10 injections of 500 mg and then under the supporting scheme once every three days for 2.5 months. Repetition of the course is carried out in 10 days.

In immunodeficient states The treatment course consists of 10 injections of intramuscular injection according to the basic scheme in a single dose of 250 mg. The total dose of 2.5 g. Repeated course is held in 6-12 months.

In rheumatic and systemic connective tissue diseases prescribed 4 courses of 5 injections on the basic scheme, 250 mg with an interval of 10-14 days. The need for a second course the doctor determines individually.

In degenerative-dystrophic diseases of the joints prescribe 2 courses of 5 injections of 250 mg with an interval of 10-14 days according to the basic scheme. The need for a second course the doctor determines individually.

Cycloferon administered i / m or / in 1 time per day. The daily therapeutic dose is 6-10 mg / kg body weight.

In acute viral hepatitis A, B, C, D and mixed forms spend 15 injections of the drug according to the basic scheme. With a protracted course of infection, repeat the course in 10-14 days.

In chronic viral hepatitis B, C, D the drug is administered according to the basic scheme of 10 injections and then under the maintenance scheme 3 times a week for 3 months as part of complex therapy. Recommended use in combination with interferons and chemotherapy.

When HIV infection (stage 2A-2B) designate a course of 10 injections according to the basic scheme and further according to the maintenance scheme 1 time in 3 days for 3 months. A second course is carried out in 10 days.

For herpes infection conduct a course of 10 injections on the basic scheme. While maintaining the replicative activity of the virus, the course of treatment is continued in a maintenance scheme with the introduction of the drug 1 every 3 days for 4 weeks.

Adverse reactions

Allergic reactions.

Special notes

For diseases of the thyroid gland, it is necessary to consult an endocrinologist.

Drug Interactions

Cycloferon is compatible with all drugs used in the treatment of these diseases (interferons, chemotherapy, symptomatic drugs, etc.). Enhances the effect of interferons and nucleoside analogues. Reduces the side effects of chemotherapy, interferon therapy.

Storage conditions

Store in a dry, dark place at temperatures from 0 ° to 25 ° C. Freezing the solution for injection during transportation (at a negative temperature) does not change the properties. Thawed at room temperature, the drug retains its biological and physico-chemical properties.

When changing the color of the solution and the formation of sediment use of the drug is unacceptable.