Elisey syrup 0.5mg/ml 100ml

pharmachologic effect

Histamine N blocker₁-receptors (long-acting). It is the primary active metabolite of loratadine. Inhibits the release of histamine and leukotriene C₄ from mast cells. Prevents the development and facilitates the course of allergic reactions. Possesses antiallergic, antipruritic and antiexudative action. Reduces capillary permeability, prevents the development of tissue edema, relieves spasm of smooth muscles. Virtually no sedative effect and when taken at a dose of 7.5 mg does not affect the speed of psychomotor reactions. In comparative studies of Desloratadine and loratadine, there were no qualitative or quantitative differences in the toxicity of the two drugs in comparable doses (taking into account the concentration of desloratadine).

Pharmacokinetics

After ingestion begins to be determined in the plasma after 30 minutes. Food does not affect distribution. Bioavailability is proportional to the dose in the range from 5 mg to 20 mg. Plasma protein binding is 83-87%. After a single dose of 5 mg or 7.5 mg C_max is achieved in 2-6 hours (on average in 3 hours). Does not penetrate the BBB. Intensively metabolized in the liver by hydroxylation with the formation of 3-OH-desloratadine, coupled with glucuronide, only a small part of the ingested dose is eliminated by the kidneys (<2%) and feces (<7%). T_1/2 - 20-30 hours (on average - 27 hours).With the use of desloratadine in a dose of 5 mg to 20 mg 1 time / day for 14 days, there were no signs of clinically significant cumulation.

Indications

Seasonal allergic rhinitis, chronic idiopathic urticaria.

Dosing regimen

Adults and adolescents aged 12 years and older are prescribed by mouth, regardless of food intake, at a dose of 5 mg / day.

Children aged 1 to 5 years old - 1.25 mg 1 time / day, from 6 to 11 years old - 2.5 mg 1 time / day.

Side effect

Nervous system: headache, hallucinations, psychomotor hyperreactivity, convulsions.

Gastrointestinal: dry mouth, hepatitis.

Other:photosensitivity, myalgia, shortness of breath, feeling tired.

Contraindications

Phenylketonuria, pregnancy, lactation, children under 1 year old, hypersensitivity to desloratadine.

Use during pregnancy and lactation

Desloratadine is contraindicated for use during pregnancy and lactation (breastfeeding).

Application for violations of kidney function

With caution prescribed desloratadine in severe renal failure.

Use in children

Contraindicated in children under 2 years.

special instructions

With caution prescribed desloratadine in severe renal failure.

Influence on ability to drive motor transport and control mechanisms

Adverse effects on driving or complex technical devices were noted.