Desloratadine pills 5mg №10

Dosage form

Packaging

10 pieces.

10 pieces

Mechanism of action

Pharmacodynamics.
Long-acting antihistamine, H1-histamine peripheral receptor blocker. Desloratadine is the primary active metabolite of loratadine. Inhibits a cascade of reactions of allergic inflammation, incl. release of pro-inflammatory cytokines including the interleukins IL-4, IL-6, IL-8, IL-13, the release of proinflammatory chemokines, production of superoxide anion by activated polymorphonuclear neutrophils adhesion and chemotaxis eosinophils selection adhesion molecules such as P-selectin, IgE - mediated release of histamine, prostaglandin D2 and leukotriene C4. Thus, it prevents the development and facilitates the course of allergic reactions, has antipruritic and antiexudative action, reduces capillary permeability, prevents the development of tissue edema, and smooth muscle spasm.
The drug has no effect on the central nervous system (CNS), practically does not have a sedative effect (does not cause drowsiness) and does not affect the speed of psychomotor reactions, does not cause prolongation of the QT interval on an electrocardiogram (ECG).
The action of desloratadine begins within 30 minutes after ingestion and lasts for 24 hours.

Pharmacokinetics
Suction.
After taking the drug inside, desloratadine is well absorbed from the gastrointestinal tract (GIT), while the determined plasma concentrations of desloratadine are reached within 30 minutes, and the maximum plasma concentration (Cmax) - after about 3 hours. Eating or drinking practically does not change the pharmacological properties of the drug.
Distribution.
The binding of desloratadine to plasma proteins is 83-87%. When used in a dose of 5 mg to 20 mg 1 time per day for 14 days, there is no evidence of clinically significant cumulation of desloratadine. Simultaneous ingestion of food or simultaneous consumption of grapefruit juice does not affect the distribution of desloratadine (when taken in a dose of 7.5 mg 1 time per day). Does not penetrate the blood-brain barrier (BBB).
Metabolism.
It is extensively metabolized by hydroxylation to form 3-OH-desloratadine coupled to the glucuronide. It is not an inhibitor of isoenzymes CYP3A4 and CYP2D6 and is not a substrate or inhibitor of P-glycoprotein.
Inference. Excreted from the body as a glucuronide compound and in a small amount in unchanged form, a small part is excreted by the kidneys (2%) and with feces (7%). The half-life (T1 / 2) is an average of 27 hours (20-30 hours).

• Seasonal (pollinosis) and perennial allergic rhinitis (elimination or relief of sneezing, nasal congestion, nasal mucus, itching in the nose, itching of the sky, itching and redness of the eyes, tearing).
• Chronic idiopathic urticaria (reduction or elimination of pruritus, rash).

Contraindications

Hypersensitivity to desloratadine and other components of the drug, pregnancy, breastfeeding period, age up to 12 years, lactose intolerance, lactase deficiency, glucose-galactose malabsorption.

Pregnancy and Breastfeeding

Use of the drug Desloratadin-Teva is contraindicated during pregnancy and during breastfeeding (there is not enough data on efficacy and safety).

Special notes

To protect pills from light, blisters should be stored in a carton box.

Influence on ability to manage transport and work with equipment
With the development of unwanted reactions from the central nervous system, such as drowsiness, dizziness, hallucinations, it is not recommended to perform actions requiring increased concentration of attention and psychomotor speed.

Composition

1 tablet, film coated, contains:
active ingredient: desloratadine 5,000 mg;
excipients: microcrystalline cellulose 65.800 mg, Magnesium oxide 2.250 mg, pregelatinized starch 4.750 mg, lactose 4.500 mg, hypromellose-4 thousand 1.700 mg, zinc stearate 1,000 mg;
film casing: Opadry blue 03B90819 2.975 mg (hypromellose 60.00%, titanium dioxide 27.21%, macrogol-400 8.00%, indigo carmine (E132 aluminum varnish) 4.79%).

Inside, regardless of the meal at the same time of day. The pill should be swallowed whole, without chewing, with a small amount of water.
Adults and children over 12 years: 5 mg 1 time per day.

Adverse reactions

The frequency of side effects is classified according to the recommendations of the World Health Organization: very often - at least 10%; often not less than 1%, but less than 10%; infrequently - not less than 0.1%, but less than 1%; rarely - not less than 0.01%, but less than 0.1%; very rarely - less than 0.01%.
On the part of the immune system: very rarely - a rash, including urticaria, angioedema, dyspnea, anaphylactic shock.
From the side of the central nervous system: infrequently - headache; very rarely - dizziness, drowsiness, insomnia, psychomotor hyperactivity, convulsions, hallucinations.
Since the cardiovascular system: very rarely - tachycardia, palpitations.
On the part of the gastrointestinal tract: infrequently - dry mouth; very rarely - nausea, vomiting, dyspepsia, diarrhea, abdominal pain, increased activity of hepatic transaminases, increased concentrations of bilirubin, hepatitis.
From the musculoskeletal system and connective tissue: very rarely - myalgia.
Other: often - increased fatigue.

Drug Interactions

No clinically significant interaction with other drugs has been identified.
Desloratadine does not enhance the action of ethanol on the central nervous system.
Eating does not affect the effectiveness of the drug.