Regulon pills №21

Composition

Ethinyl estradiol, desogestrel

Excipients: α-tocopherol, Magnesium stearate, anhydrous colloidal silicon, stearic acid, povidone, potato starch, lactose monohydrate.

Packing

21 pieces

Mechanism of action

REGULON - monophasic hormonal contraceptive drug for oral administration, containing a combination of estrogen (ethinyl estradiol) and gestagen (desogestrel). Inhibits pituitary secretion of gonadotropic hormones. The contraceptive effect is due to the effect on the hypothalamic-pituitary-ovarian system.

Desogestrel is a synthetic gestagen, when ingested, inhibits the synthesis of LH and FSH in the pituitary gland and, preventing the maturation of the follicle, effectively blocks ovulation. It has an anti-estrogenic, weak androgenic (anabolic) effect, does not have an estrogenic effect.

Ethinyl estradiol is a synthetic analogue of the follicular hormone estradiol, is involved with the hormone of the corpus luteum in the formation of the menstrual cycle. Interferes with maturation of the egg cell capable of fertilization.

The contraceptive effect is due, on the one hand, to a decrease in the susceptibility of the endometrium to the blastocyte, on the other hand, by an increase in the viscosity of mucus in the cervix, which prevents the progress of spermatozoa.

The drug has a beneficial effect on lipid metabolism: it increases the content of HDL in plasma, while not affecting the content of LDL.

When taking the drug significantly reduced menstrual blood loss. Regular intake of the drug normalizes the menstrual cycle, helps prevent the development of a number of gynecological diseases, including oncology.

It has a beneficial effect on the skin, significantly improves the condition of the skin with acne vulgaris.

Indications and usage

Oral contraception.

Contraindications

- pregnancy or suspicion of it;

- severe arterial hypertension or moderate severity;

- familial forms of hyperlipidemia;

- thromboembolism (including in history) or predisposition to it (myocardial infarction, cerebrovascular diseases (ischemic and hemorrhagic stroke), a pronounced form of atherosclerosis);

- IHD, decompensated heart disease, myocarditis;

- venous thromboembolism in personal or family history;

- diabetic angiopathy (including retinopathy);

- severe liver diseases (including history): cholestatic jaundice, hepatitis (before normalization of laboratory parameters and in the first 6 months after their normalization), jaundice during pregnancy or while taking GCS, Dubin-Johnson syndrome, Rotor syndrome, gallstone disease, liver tumor, porphyria;

- estrogen-dependent tumors or suspicion of them: breast and endometrial cancer, endometrial hyperplasia, endometriosis, breast fibroadenoma;

- genital bleeding of unknown etiology;

- Systemic lupus erythematosus (including a history);

- genital herpes, herpes pregnant;

- severe itching during pregnancy in history;

- otosclerosis (aggravated during a previous pregnancy or while taking GCS);

- hypersensitivity to the drug.

Dosage and administration

The preparation is prescribed for 1 pill / day (if possible at the same time), starting from the 1st day of the menstrual cycle for 21 days. This is followed by a 7-day break, during which menstrual bleeding occurs. Then, taking the pills from the next package is resumed (even if the bleeding has not yet stopped). When complying with the rules of admission, the contraceptive effect is maintained for the duration of the 7-day break.

If the first pill is taken on day 1 of the menstrual cycle, then no additional contraceptive methods are required. Taking the pills can be started from 2-5 days of menstruation, but in this case, in the first cycle, you need to use additional methods of contraception in the first 7 days of taking the pills.

If more than 5 days have passed after the onset of menstruation, you should postpone the start of taking the drug until the next menstruation.

After delivery to non-nursing women, the drug can be prescribed after 21 days. In this case, there is no need to use other methods of contraception. If the drug is prescribed later than 21 days after delivery, then in the first 7 days of administration it is necessary to use additional methods of contraception. If in the postpartum period, sexual contact was preceded by oral contraception, then with the intake of pills, you must wait until the first menstruation occurs.For women who continue breastfeeding, the use of combined oral contraceptives is not recommended, since taking the drug can reduce the release of milk.

After an abortion, it is recommended to start taking the drug immediately after surgery, and in this case there is no need to use additional methods of contraception.

When switching to Regulon after taking another estrogen-progestin hormonal contraceptive, the first pill of Regulon should be taken the next day after completing the course of the previous drug. In the application of additional methods of contraception is not necessary.

When switching to Regulon after taking another hormonal contraceptive containing only gestagen, Regulon's first pill should be taken on the first day of the menstrual cycle; No need for additional contraceptive methods. If you do not experience menstruation while taking the previous drug, you can start taking Regulon on any day of the cycle, but in this case, additional contraceptive methods should be used on the first 7 days of treatment.

As an additional method of contraception, the use of a cervical cap with a spermicidal gel, a condom, or abstinence from sexual contact is recommended. The use of the calendar method as an additional method of contraception is not recommended.

If necessary, postpone menstruation pills should be continued without a 7-day break.In this case, intermenstrual bleeding may occur, but this does not reduce the contraceptive effect of the drug. Regulon's regular intake can be restored after the usual 7-day break.

If you miss the drug, if the delay in taking the pill was no more than 12 hours, then you need to take the missed pill, and then continue taking it at the usual time. If the delay in taking the pill is more than 12 hours, it is considered to be a skip tablet, the contraceptive reliability in this cycle is not guaranteed and the use of additional methods of contraception is recommended.

When skipping 1 tab. In the first or second week of the cycle, it is necessary to take 2 tab. the next day and then continue regular intake, using additional contraceptive methods until the end of the cycle. When skipping 1 tab. in the third week of the cycle, in addition to the measures listed, a 7-day break is excluded.

If vomiting or diarrhea appears after taking the drug, absorption of the drug may be incomplete. If the symptoms stopped within 12 hours, then you need to take another 1 pill extra. After that, you should continue taking the pills in the usual way. If symptoms continue for more than 12 hours, it is necessary to use additional methods of contraception in the next 7 days.

Drug Interactions

With the simultaneous use of Regulon with antispasmodics, phenobarbital derivatives, antibiotics (tetracycline, ampicillin, rifampicin, isoniazid, neomycin, penicillin, chloramphenicol), Carbamazepine, phenylbutazone, analgesics, anxiolytics, Activated carbon, sulfonamides, nitrofurans, antimigraine drugs, Griseofulvin, laxatives, and some medicinal plants, using heart rate patterns, some of the patterns and patterns, in the case of using the patterns, you might have applied to the effect patterns, you are by using the patterns, you cannot apply to the settings that you’ll see what's not using the patterns that you’ll see in your account’s;

Regulon with simultaneous use reduces the effectiveness of oral anticoagulants, anxiolytics (diazepam), tricyclic antidepressants, guanethidine, theophylline, caffeine, Vitamins, clofibrate, glucocorticosteroids, Paracetamol .

With the simultaneous use of Regulon with oral hypoglycemic drugs or insulin, a violation of the control of the state of carbohydrate metabolism is possible, since Regulon may decrease carbohydrate tolerance and increase the need for insulin or oral hypoglycemic agents, which may require dose adjustment.

Symptoms: metrorrhagia. Taking the drug in high doses was not accompanied by the appearance of severe symptoms.

Treatment: in the first 2-3 hours after taking the drug in a high dose, gastric lavage is recommended. There is no specific antidote, the treatment is symptomatic.

At a temperature from 15 ° to 30 ° С.