Thiogamma solution for injection 1.2% 50ml №1

Mechanism of action

A drug that regulates metabolism. Thioctic (a-lipoic) acid is synthesized in the body and acts as a coenzyme in the oxidative decarboxylation of alpha-keto acids. It contributes to a decrease in blood glucose and an increase in glycogen content in the liver.
Thioctic acid is similar in pharmacological properties to the B Vitamins.

Overdosage

Symptoms: nausea, vomiting, headache.
Treatment: conduct symptomatic therapy. There is no specific antidote.

Drug Interactions

With the combined use of Thiogamma in the form of a solution for injection reduces the effectiveness of Cisplatin.
With simultaneous use of Thiogamma enhances the action of insulin and oral hypoglycemic agents.
When taken simultaneously with ethanol, the therapeutic efficacy of thioctic acid may decrease.
Pharmaceutical Interaction
In vitro, thioctic acid reacts with complex metal ions (for example, cisplatin), and also forms moderately soluble complex compounds with sugar molecules. Therefore, the infusion solution is incompatible with glucose solution, Ringer's solution and with solutions that can react with SH-groups or disulfide bridges.

Storage conditions

The drug in the form of pills should be stored in a dark place at a temperature of from 15 ° to 25 ° C. Shelf life of pills - 3 years.
The drug in the form of a solution for injection and solution for infusion should be stored in a dark place at a temperature of 15 ° to 25 ° C. The shelf life of a 3% solution for injection and 1.2% solution for infusion is 5 years.
Prepared infusion solutions should be closed in a wrapper that excludes light penetration.