Bonifen pills coated 275mg №20

Mechanism of action

NSAIDs, has anti-inflammatory, analgesic, and antipyretic effects associated with the suppression of cyclooxygenase 1 and 2, regulating the synthesis of prostaglandins.

Absorption from the gastrointestinal tract - fast and complete, bioavailability - 95% (food intake does not affect either the fullness or the rate of absorption). TCmax - 2-4 hours, connection with plasma proteins - 98-99%, T1 / 2 - 12-15 hours. Metabolism - in the liver to dimethylnaproxen. Clearance - 0.13 ml / min / kg. It is displayed on 98% of the kidneys, 10% of them are displayed in unchanged form; with bile - 0.5-2.5%. Css is determined in 4-5 days. When CRF possible accumulation of metabolites.

Indications and usage

Rheumatoid arthritis, osteoarthritis, ankylosing spondylitis, articular syndrome with exacerbation of gout; back pain, neuralgia, myalgia, traumatic inflammation of the soft tissues and musculoskeletal system. As a symptomatic remedy: infectious and inflammatory diseases of the upper respiratory tract, adnexitis, primary algomenorrhea, headache and toothache.

Contraindications

Hypersensitivity, erosive and ulcerative lesions of the gastrointestinal tract (in the acute phase), "aspirin" asthma, "aspirin" triad (asthma, rhinitis, recurrent nasal polyposis), inhibition of bone marrow hematopoiesis, hepatic and / or renal failure, pregnancy,lactation period, child age (up to 1 year). With care - heart failure, children's age (up to 16 years).

Inside pills should be taken whole, washed down with a liquid, can be taken with meals. In the acute stage of the disease - 0.5-0.75 g, 2 times a day. The maximum daily dose - 1.75 g. For maintenance therapy - in an average daily dose of 500 mg for 2 doses (in the morning and at night). In an acute attack of gout, the first dose is 825 mg; then 275 mg every 8 hours. With algomenorrhea, the first dose is 500 mg, then 275 mg every 6-8 hours for 3–4 days. With migraine - 500 mg. Rectal suppositories are usually prescribed for the night (1 candle of 0.5 g each). If you need to use Naproxen in high doses, you can combine the appointment in candles and tablets. Children aged 1 to 5 years - in a daily dose of 2.5-5.0 mg / kg in 1-3 doses; The course of treatment should not exceed 14 days. In juvenile arthritis in children older than 5 years, the daily dose is 10 mg / kg. The preferred dosage form for children is a suspension.

Adverse reactions

NSAID gastropathy (damage to the antrum in the form of erythema of the mucous membranes, hemorrhages, erosions and ulcers). Nausea, vomiting, epigastric discomfort, skin rash, urticaria, angioedema; headache, drowsiness, tinnitus, dizziness, weakness, slow reaction; erosive and ulcerative lesions of other parts of the gastrointestinal tract, bleeding and perforation of the gastrointestinal tract; eosinophilic pneumonia; thrombocytopenia, granulocytopenia, aplastic anemia, hemolytic anemia; hearing loss, impaired kidney or liver function. Overdose. Symptoms: heartburn, dyspepsia, nausea, vomiting, drowsiness.Treatment: gastric lavage, Activated carbon - 0.5 g / kg. Dialysis is not effective.

Cautions

If necessary, determine the 17-ketosteroids drug should be canceled 48 hours before the study. It is necessary to monitor the function of the liver and kidneys, the composition of peripheral blood. Note that naproxen increases bleeding time.

Drug Interactions

With simultaneous appointment may cause a decrease in the diuretic effect of Furosemide; enhancing the effect of indirect anticoagulants. Increases the toxicity of phenytoin, sulfonamides, Methotrexate (blocks tubular secretion). Reduces the hypotensive effect of beta-blockers. Antacid preparations containing Magnesium and aluminum reduce naproxen absorption. Reduces the excretion of salts of Li + and increases its concentration in the plasma.

Storage conditions

The drug should be stored at a temperature not higher than 25 ° C.