Teraflex capsules №60

Trade name of the drug:

Teraflex^®.

International non-proprietary or grouping name:

Glucosamine + Chondroitin Sulfate.

Dosage form

capsules.

Composition

One capsule contains:

• Active ingredients:
  • Glucosamine Hydrochloride 500 mg
  • Chondroitin sodium sulfate 400 mg
• Excipients: stearic acid 10 mg, Magnesium stearate 5 mg, manganese sulfate 1 mg.
• Gelatin capsule: gelatin 120 mg.

Description

Transparent hard gelatin capsules No. 00. The contents of the capsules are white or white with a yellowish tinge of color with crystalline particles.

Pharmacotherapeutic group

Reparation tissue stimulator.

Pharmacological properties

Stimulates the regeneration of cartilage tissue. Glucosamine and chondroitin sulfate are involved in the synthesis of connective tissue, helping to prevent the processes of cartilage destruction and stimulating tissue regeneration. The administration of exogenous glucosamine enhances the production of cartilage matrix and provides non-specific protection against chemical damage to cartilage. Another possible effect of glucosamine is to protect damaged cartilage from metabolic destruction caused by nonsteroidal anti-inflammatory drugs (NSAIDs) and glucocorticosteroids (GCS), as well as its own moderate anti-inflammatory effect.

Chondroitin sulfate serves as an additional substrate for the formation of a healthy cartilage matrix. Stimulates the formation of hyaluronon, the synthesis of proteoglycans and type II collagen, and also protects hyaluronon from enzymatic degradation (by suppressing the activity of hyaluronidase); maintains the viscosity of synovial fluid, stimulates the mechanisms of cartilage repair and inhibits the activity of those enzymes that break down cartilage (elastase, hyaluronidase). In the treatment of osteoarthritis, it relieves the symptoms of the disease and reduces the need for NSAIDs.

Pharmacokinetics

Glucosamine

Absorption. The bioavailability of glucosamine by oral intake is 25% (the effect of "first passage" through the liver).

Metabolism. After the oral dose has been absorbed, the radiolabeled glucosamine is first detected in the plasma and later penetrates the tissue. The greatest concentrations are found in the liver, kidneys and articular cartilage. About 30% of the accepted dose persists for a long time in the tissues of the bones and muscles.

Elimination. Excreted mainly by the kidneys in unchanged form; partially through the intestines. The half-life of the drug is 68 hours

Chondroitin sulfate

Absorption. When ingestion of chondroitin sulfate once at a dose of 0.8 g (or 2 times a day, 0.4 g) the plasma concentration increases over 24 hours. Absolute bioavailability is 12%.

Metabolism. Metabolized by desulfurization.

Elimination. Excreted by the kidneys. A half-life of 310 minutes.

Indications for use

Degenerative-dystrophic diseases of the joints and spine: osteoarthrosis stage I - III, osteochondrosis.

Contraindications

Hypersensitivity, severe chronic renal failure, pregnancy, lactation, age up to 15 years.

Carefully

Diabetes mellitus, bleeding tendency, bronchial asthma.

Pregnancy and lactation

Clinical data on the efficacy and safety of the drug Teraflex during pregnancy and lactation (breastfeeding) are missing.

Dosage and administration

Inside Adults and children over 15 years old are prescribed 1 capsule 3 times a day for the first three weeks; in the following days - 1 capsule 2 times a day, regardless of the meal, with a small amount of water. The recommended duration of treatment is from 3 to 6 months. If necessary, it is possible to conduct repeated courses of treatment, the duration of which is set individually.

Side effect

Teraflex is well tolerated by patients. Dysfunction of the gastrointestinal tract (epigastric pain, flatulence, diarrhea, constipation), dizziness, headache, pain in the legs and peripheral edema, drowsiness, insomnia, tachycardia, allergic reactions are possible

Overdose

Symptoms: overdose cases are unknown.

With an overdose of chondroitin sulfate, hemorrhagic rash, nausea, vomiting are possible.

Treatment: gastric lavage, symptomatic therapy.

Interaction with other drugs

Improves the absorption of tetracyclines, reduces the effect of semi-synthetic penicillins and chloramphenicol. The drug is compatible with NSAIDs and glucocorticosteroids. Chondroitin sulfate may enhance the effect of anticoagulants.

special instructions

With the appearance of undesirable effects on the gastrointestinal tract, the dose of the drug should be reduced by 2 times, and in the absence of improvement, cancel the drug.

Release form

Capsules 500 mg + 400 mg. 30, 60 or 100 capsules are placed in a bottle of high-density polyethylene with a screw cap of the same material. The vial is glued with a membrane made of a composite material: aluminum foil / paper laminated with polyethylene. The lid and neck of the vial are sealed with a transparent film. Each bottle together with the application instruction is placed in a cardboard pack.

Storage conditions

At a temperature not higher than 25 ° С.

Keep out of the reach of children.

Shelf life

3 years.

Do not use after expiration date.

Vacation conditions

Over the counter.