Yodilife pills №28

Mechanism of action

Folic acid belongs to the B Vitamins. In the body, folic acid is reduced to tetrahydrofolic acid, which is involved in the synthesis of purines and pyrimidines, the metabolism of choline, and in general in the metabolism of nucleic acids and proteins. It plays an important role in the formation of the central nervous system, which develops in humans 15-28 days after fertilization. A lack of folic acid causes the development of neural tube defects in the fetus.

Vitamin B and inside the cell exists as two active coenzymes: methylcobalamin and adenosylcobalamin. Methylcobalamin is necessary for the operation of methionine synthetase, which is involved in the metabolism of folic acid. This interaction of folic acid with cobalamin is necessary for the normal synthesis of purines and pyrimidines, and, therefore, DNA. With a deficiency of vitamin B₁₂ or folic acid reduced synthesis of methionine and S-adenosylmethionine disrupts many methylation reactions, synthesis of proteins and polyamines.

Pharmacological action of the drug Yodilayf is that its use allows you to overcome the metabolic blockade, which is observed in children with neural tube defects.

The specific nature of this metabolic blockade is the metabolism of the essential amino acid methionine, in which folic acid and vitamin B₁₂ are key elements because they are responsible for the re-methylation of homocysteine ​​to methionine.

400 micrograms of folic acid is the minimum effective daily dose recommended by the Centers for Disease Prevention (USA, UK and Australia) to healthy women as an additional daily intake to prevent the development of neural tube defects in the fetus. The recommended daily intake of vitamin B₁₂ is 2 mcg.

Iodine is the main element for the synthesis of thyroid hormones, thyroxin (T₄) and triiodothyronine (T₃) (mass fraction of iodine in which is 65% and 59%, respectively). Thyroid hormones are necessary at all stages of life for the normal functioning of the CNS. Iodine is not only the main substrate of the thyroid gland used in the synthesis of iodine-containing thyroid hormones, but also directly affects the brain cells of the embryo.

Pharmacokinetics

Folic acid is rapidly absorbed in the jejunum, undergoing recovery and methylation to 5-methyltetrahydrofolate. C_max observed in plasma after 30-60 minutes.

Intensively binds to plasma proteins. It penetrates the blood-brain barrier into the placenta and breast milk. Excreted by the kidneys mainly in the form of metabolites. Vitamin B₁₂ may be absorbed after its interaction in the stomach with the internal factor of Castle, a glycoprotein that is secreted by the parietal cells of the stomach. C_max in plasma is observed after 8-12 hours. As in the case of folic acid, vitamin B₁₂ undergoes a significant enterohepatic recirculation.

Average t_1/2 vitamin b₁₂ is about 6 days. Part of the dose administered is excreted by the kidneys during the first 8 hours, although most is excreted in the bile. 25% is excreted through the intestines. In addition, vitamin B12 penetrates the placenta and is present in breast milk.

Vitamin B₁₂ largely associated with plasma proteins, the excess accumulates in the liver.

Iodine has good absorption. It is believed that the coefficient of intestinal absorption of iodine after taking water-soluble iodine salts (for example, potassium iodide) is 100%. The mechanism of intestinal absorption of iodine is not known.

After completion of the absorption process, iodine rapidly spreads through the extracellular fluid. Iodine penetrates the placental barrier and is present in human milk. Iodine is transported to other tissues (with the exception of thyroid tissue): the mammary / salivary glands and the intestinal mucosa.

The main part of iodine is excreted by the kidneys and a small amount with saliva, milk, sweat, bile and through the intestines.

Indications

- prevention of iodine, folic acid and vitamin B12 (cyanocobalamin) deficiency in women of childbearing age at the planning stage of pregnancy (at least 1 month before conception);

- prevention of the development of neural tube defects in the fetus in the first trimester of pregnancy.

Dosage and administration

1 pill per day, before meals.

The course of prophylactic treatment in women of childbearing age at the planning stage of pregnancy is at least 1 month prior to conception and during the first trimester of pregnancy. Repeated courses on the recommendation of a doctor.

Side effect

Violations of the gastrointestinal tract: diarrhea, nausea, vomiting, bloating and abdominal pain, flatulence, metallic taste in the mouth and increased salivation.

Endocrine Disorders: goiter, hyperthyroidism and hypothyroidism.

Violations of the cardiovascular system: vasculitis, periarthritis with fatal outcome.

Immune system disorders: dropsy (including swelling of the face and glottis).

Violations of the skin: pruritus, rash and erythema, urticaria, rash, and angioedema.

Violations of the circulatory and lymphatic systems: thrombocytopenic purpura.

Other disorders: hypersensitivity, general malaise, signs and symptoms similar to serum sickness: fever, joint pain, lymphatic cyst formation and eosinophilia.

Contraindications

- lactation period;

- childhood;

- increased individual sensitivity to the components of the drug.

The drug contains lactose. Patients with hereditary intolerance to galactose, lactase deficiency or impaired absorption of glucose or galactose drug is contraindicated.

With a daily dose of more than 150 mg / day, potassium iodide is contraindicated in patients with acute bronchitis, severe and latent hyperthyroidism.

Carefully: hypocomplementemic vasculitis, goiter or autoimmune thyroiditis, kidney diseases, chronic hyperkalemia, active tuberculosis, epilepsy.

Use during pregnancy and lactation

The drug is recommended for use during pregnancy.

The components of the drug penetrate into breast milk. Since there are currently no data on the use of the drug during this period, the drug is not recommended for use during breastfeeding.

Application for violations of kidney function

With caution in kidney disease.

Use in children

Contraindicated in children.

Special notes

It should be borne in mind that antibiotics may distort (to give underestimated results) the results of analysis of plasma and erythrocyte folate concentrations. In view of the effect of iodides on the thyroid gland, taking these drugs can lead to a distortion of the results of the study of thyroid function. You should not take a double dose of the drug if you miss the next reception. The use of the drug does not affect the performance of potentially hazardous activities that require special attention and quick reactions (driving, working with moving machinery, the work of the dispatcher and operator, etc.).

Overdosage

In case of overdose or accidental ingestion of the drug, you should immediately consult a doctor.

Symptoms of overdose: metallic taste in the oral cavity, increased sensitivity of the teeth and gums,increased salivation, irritation of the mucous membrane of the nasal cavity, sneezing, swelling of the eyelids (symptoms known as "iodism").

In addition, overdose of the drug can cause severe headache, cough, pulmonary edema, dysfunction of the parotid and submandibular glands, inflammation of the pharynx, larynx and tonsils, moderately pronounced skin rash on seborrheic areas, disorders of the gastrointestinal tract (diarrhea).

In case of overdose, it is necessary to stop taking the drug and consult a doctor. Symptomatic treatment.

Drug interaction

Iodilife should not be taken in combination with Methotrexate , pyrimethamine, triamterene, trimethoprim, because they act as antagonists of folic acid, inhibiting tetrahydrofolate reductase.

Taking the drug Yodilife in combination with antiepileptic drugs from the group of hydantoin (phenytoin) can reduce the effect of the latter.

Analgesics (with long-term therapy), estrogens and oral contraceptives increase the need for folic acid.

Antacids (including Calcium , aluminum and Magnesium preparations), colestiramine, sulfonamides (including sulfasalazine) reduce folic acid absorption.

The simultaneous use of the drug with potassium-sparing diuretics can lead to a decrease in the elimination of potassium by the kidneys, as a result of which the likelihood of severe chronic hyperkalemia will arise.

Concomitant use of lithium and potassium salts can lead to hypothyroidism.

Simultaneous use with antithyroid drugs can lead to increased hypothyroidism.

Terms and conditions of storage

At a temperature not higher than 25 ° С. Keep out of the reach of children. Shelf life - 3 years.

Pharmacy sales terms

On prescription.