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Euphyllin ampoules 2.4% 10ml №10
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Active ingredient and dosage form
Pills: 1 pill contains 150 mg of aminophylline;
10, 20, 30, 50 pcs. packaged.
Solution for injection 2.4%: 1 ml contains 24 mg of aminophylline;
1, 5, 10 ml in ampoules, 10 ampoules per pack.
Mechanism of action
Bronchodilator drug.
Aminophylline is a mixture of 80% theophylline (1,3-dimethylxanthine) and 20% ethylenediamine (1,2-ethylenediamine), which facilitates its solubility and improves absorption.
The drug inhibits phosphodiesterase and increases the accumulation of c-AMP in tissues, blocks adenosine receptors, has the ability to inhibit the transport of Calcium ions through the channels of cell membranes. Relaxes the muscles of the bronchi, relieves bronchospasm. Several dilates the vessels of the heart, brain, kidneys, is a peripheral vasodilator. It has a moderate diuretic effect. Inhibits platelet aggregation.
It has a stimulating effect on the respiratory center, increases the frequency and strength of heart contractions.
Chronic obstructive bronchitis, bronchial asthma (a drug of choice in patients with physical stress asthma and as an additional remedy for other forms), asthmatic status (adjuvant therapy), pulmonary emphysema, neonatal apnea (a condition characterized by periods of not breathing for 15 seconds and accompanied cyanosis and bradycardia), Cheyne-Stokes respiration.
Contraindications
Hypersensitivity, including xanthine derivatives (caffeine, Pentoxifylline, theobromine), arrhythmia, hypertension, pathology infarction, myocardial infarction, heart failure, acute and chronic (acute phase), gastritis, gastric ulcer and duodenal ulcer, prostate adenoma, diarrhea, cystic fibrous mastopathy, alcoholism, pulmonary heart, fever, hypoxemia, respiratory infections, liver dysfunction, hyperthyroidism, chronic and acute renal failure, edema first syndrome, hypernatremia, rectal diseases, breastfeeding.
Dosage and administration
The dose of the drug is set individually.
Inside for adults should be applied at 0.15 g per reception 1-3 times a day after meals, for children at the rate of 7-10 mg / kg per day in 4 doses.
If necessary, the dose of the drug can be increased with an interval of 2-3 days to achieve the optimal therapeutic effect.
Duration of treatment from several days to several months.
Intravenous administration of the drug should be carried out carefully and slowly, at least for 5 minutes. The dose of the drug is selected individually, given the possibility of different rates of excretion in different patients.
Adverse reactions
Are possible: lack of appetite, nausea, headache, tachycardia, anxiety, dizziness, vomiting, cardiac arrhythmias, albuminuria, hematuria, allergic reactions in the form of skin rash.
Seldom: convulsions, aggravation of peptic ulcer, hypoglycemia.
The drug is prescribed with caution to patients with a fever of unknown origin, the elderly.
Euphyllin can raise level of uric acid in urine.
When prescribing a drug in periods of pregnancy and lactation It is necessary to compare the expected benefits to the mother and the potential risk to the fetus or newborn.
Use caution when consuming large amounts of caffeine-containing foods or beverages during treatment.
Before parenteral administration, the solution must be heated to body temperature.
Drug Interactions
Pharmacodynamic interaction
With simultaneous use with eufillinom bronchodilating effect of terbutaline and Salbutamol increases. Simultaneous use of Euphyllin with beta-blockers can cause bronchospasm.
Pharmacokinetic interaction
Cimetidine, Erythromycin, influenza vaccine and oral contraceptives enhance the effect of Euphyllin, increasing its concentration in the patient's blood plasma.
With simultaneous appointment with Carbamazepine, phenytoin, rifampicin, the concentration of Euphyllin in the blood plasma decreases. Nicotine activates metabolism and elimination of Euphyllin.
With simultaneous use of Euphyllin increases the excretion of lithium.
List B. In a dry place protected from light.
Euphyllin