Salbutamol aerosol 100 mcg 200 doses

Inhalation aerosol

Composition

1 dose contains: salbutamol sulfate 0.1208 mg (equivalent to 0.1 mg salbutamol).
Excipients: oleyl alcohol, ethanol (rectified ethyl alcohol), propellant R 134a (1,1,1,2-tetrafluoroethane, HFA 134a). The drug does not contain chlorofluorocarbon propellants.

Packing

Inhaler and inhalation device contains 200 doses of the drug. In a cardboard bundle 1 inhaler in a case.

Mechanism of action

Salbutamol is a selective β-2-adrenoreceptor antagonist. In therapeutic doses, it acts on the β-2-adrenoreceptors of the smooth muscles of the bronchi, providing a pronounced bronchodilator effect, prevents and stops bronchospasm, increases lung capacity. It prevents the release of histamine, a slow-reacting substance from mast cells and neutrophil chemotactic factors. Causes a slight positive chrono-and inotropic effect on the myocardium, the expansion of the coronary arteries, practically does not reduce blood pressure. It has a tocolytic effect: lowers the tone and contractile activity of the myometrium.The action of the drug begins 5 minutes after inhalation and lasts for 4-6 hours. It has a number of metabolic effects: it lowers K + in plasma, affects glycogenolysis and insulin secretion, has hyperglycemic (especially in patients with bronchial asthma) and lipolytic effect, increases the risk of acidosis.

Indications and usage

Prevention and relief of bronchospasm with:
- Bronchial asthma.
- Chronic obstructive pulmonary disease (COPD).
- Chronic bronchitis.
- Emphysema of the lungs.

Contraindications

- Heart rhythm disorders (paroxysmal tachycardia, polytopic ventricular premature beats), tachyarrhythmias.
- Myocarditis.
- Heart defects, aortic stenosis.
- Coronary heart disease.
- Thyrotoxicosis.
- Decompensated diabetes.
- Glaucoma.
- Epilepsy.
- Pyloroduodenal constriction.
- Liver failure.
- Renal failure.
- Pregnancy.
- Simultaneous reception of non-selective beta-blockers.
- Children's age up to 2 years.
- Hypersensitivity to any component of the drug.
Be wary appoint the drug in the following cases:
- Chronic heart failure.
- Hyperthyroidism.
- Arterial hypertension.
- Pheochromocytoma.

Pregnancy and Breastfeeding

The drug is contraindicated for use in pregnancy. During lactation (breastfeeding) prescribed only in cases where the expected benefit to the mother outweighs any potential risk to the child.

Dosage and administration

Adults and children over 12 years old - 100-200 mcg Salamol Eco (1-2 inhalation doses) for stopping asthma attacks.
To control the course of asthma of mild severity - 1-2 doses 1-4 times per day and moderate severity of the disease - in the same dosage in combination with other anti-asthma drugs.
For the prevention of physical asthma - 20-30 minutes before the load of 1-2 doses per dose.
Children from 2 to 12 years with the development of an attack of bronchial asthma, as well as to prevent attacks of bronchial asthma associated with exposure to an allergen or exercise, the recommended dose is 100-200 mg (1 or 2 inhalations).
The daily dose of salbutamol should not exceed 800 micrograms (8 inhalations).

Adverse reactions

From the side of the central nervous system: tremor of the hands (a typical side effect for all beta2-adrenergic agonists), headache, dizziness, irritability, anxiety, sleep disturbance, insomnia. The drug can cause arousal and increased motor activity in children.
Cardiovascular: the expansion of peripheral vessels (flushing of the skin of the face), a slight compensatory increase in heart rate, increased blood pressure. Arrhythmias may occur (including atrial fibrillation, supraventricular tachycardia, and extrasystole).
Allergic reactions: in rare cases - angioedema, urticaria, erythema, nasal congestion, bronchospasm, hypotension, collapse.
Gastrointestinal: nausea, vomiting, dyspepsia.
Respiratory: paradoxical bronchospasm, irritation of the mucous membranes of the mouth and pharynx (pharyngitis), cough.
Metabolism: possible hypokalemia (may pose a serious danger to the patient), reversible hyperglycemia.
Other: muscle cramps.

In patients with severe or unstable bronchial asthma, the use of bronchodilators should not be the main or only method of therapy. If the effect of the usual dose becomes less effective or less prolonged (the effect of the drug must be maintained for at least 3 hours), the patient should consult a doctor. Frequent use of salbutamol can lead to increased bronchospasm, sudden death, and therefore it is necessary to take breaks of several hours between taking the next dose of the drug. The increased need for the use of inhaled β-2-adrenoreceptor agonists with a short duration of action to control the symptoms of bronchial asthma indicates an exacerbation of the disease. In such cases, the patient’s treatment plan should be reviewed and the question of prescription or increase of the dose of inhaled or systemic glucocorticosteroids (GCS) should be decided. Therapy with β-2-adrenoreceptor agonists can lead to hypokalemia. Particular caution is recommended when treating severe attacks of bronchial asthma, since in these cases hypokalemia may be enhanced by the simultaneous use of xanthine derivatives, GCS, diuretics, and also due to hypoxia. In such situations, it is necessary to control the level of potassium in the serum. Spray can not pierce, disassemble or throw into the fire, even if it is empty. Like most other inhalants in aerosol packages, Salamol Eco may be less effective at low temperatures. When cooling the cartridge, it is recommended to get it out of the plastic case and warm it with your hands for a few minutes.

Drug Interactions

Theophylline and other xanthines, while being used with salbutamol, increase the likelihood of developing tachyarrhythmias; means for inhalation anesthesia, levodopa - severe ventricular arrhythmias. It is not recommended to use both Salamol Eco and non-selective beta-adrenoreceptor blockers such as propranolol. Monoamine oxidase inhibitors and tricyclic antidepressants increase the effects of salbutamol and can lead to a sharp decrease in pressure. Salbutamol enhances the action of central nervous system stimulants, side effects of thyroid hormones, and cardiac glycosides. Reduces the effectiveness of antihypertensive drugs, nitrates. Hypokalemia may be enhanced by the simultaneous use of xanthine derivatives, glucocorticosteroids, and diuretics. Simultaneous administration with anticholinergic agents (including inhalants) may contribute to an increase in intraocular pressure.

Overdosage

Symptoms: nausea, vomiting, irritability, hallucinations, tachycardia, trembling of the ventricles, dilatation of peripheral vessels, lowering of arterial pressure, hypoxemia, acidosis, hypokalemia, hyperglycemia, muscular tremor, headache.
Treatment: drug withdrawal, cardioselective beta-blockers; symptomatic therapy. If overdose is suspected, the level of serum potassium should be monitored.

Storage conditions

Store at a temperature not higher than 30 ° С, protecting from direct sunlight.