Signicef ​​eye drops dropper bottle 0.5% 5ml

Eye drops

Active ingredient

1 ml of the preparation contains: Levofloxacin hemihydrate, equivalent to levofloxacin 5.0 mg.
Excipients: benzalkonium chloride, hypromellose, sodium chloride, sodium hydroxide, hydrochloric acid, water for injection.

Packing

In a plastic dropper bottle 5 ml solution. In the package 1 bottle.

Mechanism of action

Signnicef ​​is an antibacterial drug of the fluoroquinolone class, levofloxacin blocks DNA gyrase and topoisomerase IV, disrupts superspiralization and cross-linking of DNA breaks, suppresses DNA synthesis, causes profound morphological changes in the cytoplasm, cell wall and bacteria membranes. In vitro activity of levofloxacin is about 2 times more than for Ofloxacin against representatives of Enterobacteriaceae, P. aeruginosa and gram-positive microorganisms.
The drug is effective against: Gram-negative aerobes - Branhamella (Moraxella) catarrhalis, Haemophilus influenzae, Neisseria gonorrhoeae, Pseudomonas aeruginosa; Gram-positive aerobes - Staphylococcus aureus, Streptococcus pneumoniae, Streptococcus pyogenes; other microorganisms sensitive to levofloxacin - Chlamydia trachomatis.
The maximum concentration of levofloxacin, achieved with 5 mg / ml eye drops, is more than 100 times greater than the minimum inhibitory concentration (MIC) of levofloxacin for sensitive microorganisms.

Indications and usage

A sign is assigned to adults and children ages 1 and older to:
- Treatment of infections of the accessory apparatus of the eye and the anterior segment of the eye caused by the levofloxacin-sensitive flora.
- Prevention of complications after surgical and laser operations on the eye.

Contraindications

Hypersensitivity to any of the components of the drug or to other quinolones, pregnancy, breastfeeding period, children under 1 year. With care: children's age up to 18 years.

Pregnancy and Breastfeeding

Contraindicated in pregnancy and lactation.

Dosage and administration

Locally, in the affected eye. 1-2 drops to the affected eye (a) every two hours up to 8 times a day during the waking period for the first 2 days, then four times a day from 3 to 5 days. The duration of treatment is determined by the doctor, usually 5 days.

Adverse reactions

Side effects can occur in about 10% of patients. Frequent side effects (1-10% of patients) - decreased visual acuity and the appearance of mucous cords. Rare side effects (0.1-1% of patients) - blepharitis, chemosis, papillary growths on the conjunctiva, eyelid edema, discomfort in the eye, burning and itching in the eye, blurred vision, pain in the eye, conjunctival hyperemia, mucous discharge, folliculosis conjunctiva, dry eye syndrome, eyelid erythema, contact dermatitis, photophobia and allergic reactions, headache, rhinitis.

Special notes

Eye drops Signitsef 0.5% can not be administered subconjunctivally and in the anterior chamber of the eye.With the simultaneous use of other ophthalmic agents, the interval between instillations should be at least 15 minutes. Drops should not be used while wearing hydrophilic (soft) contact lenses, due to the presence of preservatives in the drops benzalkonium chloride, which can be absorbed by contact lenses and have an adverse effect on eye tissue, and also cause discoloration of contact lenses. To avoid contamination of the dropper tip and solution, do not touch the eye when instillation.

Drug Interactions

Special studies on the interaction of eye drops Signnicef ​​0.5% was not conducted. Since the maximum concentration of levofloxacin in plasma after topical application in the eye is at least 1000 times lower than after taking standard oral doses, interaction with other drugs characteristic of systemic use is clinically insignificant.

Overdosage

The total amount of levofloxacin contained in a single vial of eye drops is too small to cause toxic reactions even after accidental ingestion.
Symptoms: possible increased side effects.
Treatment: After topical application of an excess dose of 0.5% Signnicef ​​eye drops, the eyes should be washed with clean water at room temperature.

Storage conditions

Store at a temperature not exceeding 30 ° C in a dark place, do not freeze.