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Imodium pills lyophilized 2mg №6
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Drug description
Mechanism of action
Antidiarrheal drug. Loperamide, binding to opioid receptors in the intestinal wall, suppresses the release of acetylcholine and prostaglandins, thereby reducing peristalsis and increasing the time for the contents to pass through the intestines. Increases the tone of the anal sphincter, reducing the incontinence of fecal masses and the urge to defecate.
Composition
loperamide hydrochloride 2 mg
Excipients: gelatin, mannitol, aspartame, mint flavor, sodium bicarbonate.
Indications for use of the drug IMODIUM®
- acute and chronic diarrhea;
- for the purpose of stool regulation in patients with ileostomy.
The drug is prescribed inside.
In acute diarrhea, adults and elderly patients are prescribed at an initial dose of 4 mg, and further, 2 mg after each bowel movement in the case of liquid stool. Children older than 6 years are prescribed in an initial dose of 2 mg, and further on, 2 mg after each defecation in the case of liquid stool.
In chronic diarrhea, adults and elderly patients are prescribed at an initial dose of 4 mg / The dose is then adjusted so that the stool frequency is 1-2, which is usually achieved with a maintenance dose of 2-12 mg / Children over 6 years of age are prescribed at an initial dose of 2 mg / Next, the dose is adjusted so that the stool frequency is 1-2, which is usually achieved with a maintenance dose of 2-12 mg /
The maximum daily dose for acute and chronic diarrhea in adults is 16 mg; in children, 6 mg per 20 kg of body weight — up to 16 mg.
With the appearance of normal stool or in the absence of stool more than 12 hours, the drug is canceled.
A lozenge should be put on the tongue. Within a few seconds, it dissolves on the surface of the tongue and can be swallowed with saliva without drinking water.
Adverse reactions
On the part of the digestive system: constipation and / or bloating, intestinal colic, pain or discomfort in the abdomen, nausea, vomiting, dry mouth; very rarely - intestinal obstruction.
From the side of the central nervous system and peripheral nervous system: fatigue, drowsiness, dizziness.
Allergic reactions: skin rash.
Other: perhaps a burning sensation or tingling of the tongue that occurs immediately after taking the drug in the form of lozenges; rarely - urinary retention.
Contraindications to the use of the drug IMODIUM®
- acute dysentery and other gastrointestinal infections (caused, including Salmonella spp., Shigella spp., Campylobacter spp.);
- intestinal obstruction (including, if necessary, to avoid suppression of peristalsis);
- diverticulosis;
- acute ulcerative colitis;
- pseudomembranous enterocolitis (diarrhea caused by antibiotics);
- I trimester of pregnancy;
- lactation period (breastfeeding);
- children's age up to 6 years;
- Hypersensitivity to loperamide and / or other components of the drug.
Precautions should be prescribed the drug for liver failure.
Use of the drug IMODIUM® during pregnancy and lactation
Imodium® is contraindicated in the first trimester of pregnancy.
Despite the absence of indications of teratogenic or embryotoxic effects, in the II and III trimesters of pregnancy Imodium® can be prescribed only in cases where the intended benefit of therapy for the mother outweighs the potential risk to the fetus.
Loperamide in small quantities excreted in breast milk, so if you need to use the drug during lactation, breastfeeding should be stopped.
Application for violations of the liver
Precautions should be prescribed the drug for liver failure. Patients with impaired liver function should be carefully monitored in order to timely detect signs of toxic damage to the central nervous system.
Special notes
The drug should be stopped immediately if constipation or bloating develops.
Since the treatment of diarrhea by Imodium is only symptomatic, it is also necessary, if possible, to use etiotropic agents.
In diarrhea, especially in children, hypovolemia and a decrease in the content of electrolytes may occur. In such cases, replacement therapy is the most important for replenishing fluids and electrolytes.
In case of acute diarrhea, if no clinical improvement is observed within 48 hours, Imodium should be stopped and infectious diarrhea should be excluded.
Do not use if diarrhea is mixed with blood in the stool and high fever.
Patients with AIDS should immediately discontinue treatment at the first sign of abdominal distention. In some cases, patients with AIDS with infectious colitis of both viral and bacterial nature during the treatment with Imodium may develop toxic expansion of the colon.
Patients with impaired liver function should be carefully monitored in order to timely detect signs of toxic damage.
During the period of treatment, it is recommended to follow the diet and replenish the fluid.
It should be borne in mind that the lozenges are quite fragile, so in order to avoid damage, they can not be forced through the foil. In order to get the pill from the blister it is necessary to take the foil by the edge, completely remove it from the hole in which the pill is located, and carefully pressing the bottom, take the pill out of the package.
Influence on ability to drive motor transport and control mechanisms
During the period of treatment, it is necessary to refrain from driving vehicles and practicing potentially hazardous activities that require high concentration of attention and high speed of psychomotor reactions.
Overdose
Symptoms: CNS depression - stupor, impaired coordination, drowsiness, miosis, increased muscle tone, respiratory depression, intestinal obstruction. Children are more sensitive to effects on the central nervous system.
Treatment: gastric lavage, the appointment of Activated carbon (no later than 3 hours after taking Imodium), mechanical ventilation, symptomatic therapy. The antidote is naloxone. Sincethe duration of action of Imodium is longer than that of naloxone (1-3 hours); it may be necessary to reappoint the latter. To identify possible inhibition of the central nervous system, the patient should be carefully monitored for at least 48 hours.
Terms and conditions of storage
The drug should be stored out of reach of children at a temperature of 15 ° to 30 ° C. Shelf life - 5 years