Durov eye drops bottle/dropper 2.5ml

Eye drops

Active ingredient

1 ml of drops contains Timolol maleate - 5 mg, travoprost - 40 mg,
Excipients: benzalkonium chloride, mannitol, trometamol, hydrogenated polyoxyethylene castor oil 40 (HCO - 40), boric acid, edetate disodium, trometamol and / or hydrochloric acid (for pH adjustment), purified water.

Packaging

Bottle of 2.5 ml.

Mechanism of action

Duotrav contains two active substances: travoprost and timolol maleate. These two components reduce intraocular pressure by a complementary mechanism of action and, as a result of the combination, provide an additional reduction in intraocular pressure. Travoprost is an analogue of prostaglandin F2α, a highly selective agonist that has high affinity for the prostaglandin FP receptor and reduces intraocular pressure by increasing the outflow of intraocular fluid through the retina and uveoscleral tract. The reduction of intraocular pressure in humans begins approximately 2 hours after instillation, the maximum effect is achieved after 12 hours. A significant decrease in intraocular pressure can be observed within 24 hours with a single dose.Timolol is a non-selective adrenergic blocker, which lacks internal sympathomimetic, direct myocardiodepressive or membrane – stabilizing activity, the effect is mainly associated with a decrease in intraocular fluid secretion and a slight increase in outflow.

Indications and usage

- Increased intraocular pressure in patients with open-angle glaucoma, which does not react to the local action of beta-blockers or prostaglandin analogues;
- Ocular hypertension of various etiologies.

Contraindications

- Hypersensitivity to any of the components of the drug
- Bronchial asthma
- Chronic obstructive pulmonary disease mild or severe
- Atrioventricular block II and III
- Cardiogenic shock
- Severe heart failure
- Allergic rhinitis severe
- Bronchial hyperactivity
- Cornea dystrophy
- Hypersensitivity to other β – blockers.

Dosage and administration

DuoTrav buried in a conjunctival sac, 1 drop 1 time a day in the affected eye (s), in the morning or in the evening, at the same time.
After exposure, it is recommended to press the nasolacrimal canal or carefully close the eyelids. This reduces the systemic absorption of the drug and serves to prevent the development of adverse systemic reactions.
If the dose was missed, treatment should be continued with the next dose on a schedule. The dose should not exceed 1 drop per day in the affected eye (s).
When replacing another antiglaucoma drug with DuoTrav eye drops, it is necessary to stop taking the replacement drug and start taking DuoTrav the next day. When using several topical ophthalmic preparations, it is necessary to observe an interval between instillations of at least 5 minutes.
Do not touch the eyes with a pipette tip or any other surface to avoid contamination of the contents of the vial.

Adverse reactions

Local: 
Eye Irritation: hyperemia, tearing, conjunctival edema, photophobia, punctate keratitis, corneal pigmentation, hyphema, painful sensations in the eye.
Visual discomfort: decrease in visual acuity, blurred vision, asthenopia, dry eyes, allergic conjunctivitis, edema, and increased vascular permeability of the conjunctiva.
Eyelid irritation: redness, dermatitis, increased eyelash growth.
System: 
When absorbing the ingredients of the drug in rare cases may occur: violation of heart rhythm, increased blood pressure, lower heart rate, lower blood pressure, chest pain, asthenia, headache, dizziness, nervousness, depression, bronchospasm, shortness of breath, cough, sore throat, nasopharyngeal discharge, pain in the extremities, chromaturia, urticaria, hyperpigmentation of the skin around the eyes, contact dermatitis.

Drug interactions

Timolol can interact with other drugs.
The effect on intraocular pressure or the systemic effect of β-blockers can be strengthened with DuoTrav ™ eye drops, if the patient receives oral β-blockers in addition to eye drops.
When using timolol eye drops simultaneously with oral Calcium channel blockers, guanitidine or β-blockers, antiarrhythmic drugs, cardiac glycosides or parasympathomimetic agents, an additional effect is observed in patients with hypotension and / or significant bradycardia.
Hypertonic reaction that occurs when abruptly cancel clonidine, can be enhanced by the use of β-blockers. β-blockers may enhance the hypoglycemic effect of antidiabetic drugs, and may also mask the symptoms of hypoglycemia
The simultaneous use of two drugs from the group of β-blockers and prostaglandins is not recommended.

Overdosage

Symptoms: increased side effects of the drug.
Treatment: symptomatic. Timolol is not dialyzed. If an excessive amount of the drug gets into the eye, wash the eyes with plenty of warm water.

Storage conditions

Store upright at +20 to +25^aboutC.