Nimesulide pills 100mg №20

Indications

Osteoarthritis, extra-articular rheumatic diseases, pain and inflammation after surgery, pain and fever in acute inflammatory processes in the upper respiratory tract, pain associated with dysmenorrhea.

Dosage and administration

Inside adults 100-200 mg 2 times / day, children - 1.5 mg / kg 2-3 times / day.

Maximum dose for children - 5 mg / kg / day in 2-3 doses.

Adverse effects

Gastrointestinal: heartburn, nausea, stomach pain; in some cases - tarry stools, melena (associated with bleeding and erosive and ulcerative lesions of the gastrointestinal tract).

From the side of the central nervous system: rarely - headaches, dizziness, drowsiness.

Allergic reactions: skin rash, erythema, urticaria.

Other: rarely, oliguria, fluid retention, local or systemic edema; in some cases - thrombocytopenic purpura.

Contraindications

Peptic ulcer and duodenal ulcer in the acute phase, acute bleeding from the gastrointestinal tract, moderate and severe liver failure, renal failure (CC less than 30 ml / min), pregnancy, lactation; hypersensitivity to Nimesulide and other NSAIDs (including acetylsalicylic acid).

Use during pregnancy and lactation

Nimesulide is contraindicated for use during pregnancy and lactation.

There is no direct indication of the embryotoxic and tocolytic effects of nimesulide.

Application for violations of the liver

Contraindicated in moderate and severe liver failure.

Application for violations of kidney function

Contraindicated in renal failure (CC less than 30 ml / min).

Use in children

When used in pediatrics should use dosage forms intended for children. In children under 6 years of age when nimesulide is used externally, medical supervision is required.

Use in elderly patients

When applied externally, the physician must be monitored for the condition of elderly patients with impaired renal function, liver, and congestive heart failure.

Special notes

With caution should be used orally in patients with impaired renal function, with hypertension, with disorders of the heart, visual impairment.

When applied externally, the physician must be monitored for the condition of elderly patients with impaired renal function, liver, and congestive heart failure.

When used in pediatrics should use dosage forms intended for children. In children under 6 years of age when nimesulide is used externally, medical supervision is required.

Influence on ability to drive motor transport and control mechanisms

Due to the fact that nimesulide can be dizziness and drowsiness when administered orally, it should be used with caution in patients engaged in potentially hazardous activities,requiring increased attention span and quick psychomotor reactions.

Drug interaction

Manifestations of drug interactions are possible with simultaneous ingestion of nimesulide with Digoxin, phenytoin, lithium preparations, diuretics, antihypertensive drugs, other NSAIDs, anticoagulants, cyclosporine, Methotrexate, oral hypoglycemic agents.