Oxyprogesterone capronate 12.5% ​​1ml ampoule №10

Active ingredient and dosage form

Solution for intramuscular administration:
1 ampoule with 1 ml solution for injections in peach or olive oil contains hydroxyprogesterone capronate 125 mg (12.5%); in the package 10 pcs.

Mechanism of action

Progestogenic.
Oxyprogesterone capronate is an analogue of the hormone of the corpus luteum (progesterone). Chemically different from Progesterone in that in position 17 contains a residue of caproic acid. Being an ester of hydroxyprogesterone, is slower progesterone metabolized (has a longer effect). After a single intramuscular injection of the oil solution, its action lasts from 7 to 14 days. Biological properties similar to progesterone. By binding to receptors on the surface of target organ cells, it penetrates into the nucleus, where, by activating DNA, it stimulates RNA synthesis. It promotes the transition of the uterine mucous membrane from the proliferation phase caused by follicular hormone to the secretory one, and after fertilization creates the necessary conditions for the implantation and development of the fertilized egg. Reduces the excitability and contractility of the muscles of the uterus and fallopian tubes, stimulates the development of the terminal elements of the mammary gland.

Indications and usage

Conditions associated with insufficiency of the corpus luteum: threatening and started miscarriage (prevention and treatment), amenorrhea (primary and secondary), dysfunctional uterine bleeding.

Contraindications

Hepatitis, liver failure, cancer of the mammary gland and genitals, tendency to thrombosis. C caution. Diseases of cardiovascular diseases, arterial hypertension, chronic renal failure, diabetes, bronchial asthma, epilepsy, migraine, depression; hyperlipoproteinemia, ectopic pregnancy, lactation.

Dosage and administration

Intramuscularly. For the purpose of prevention and treatment of threatened and begun miscarriage injected at 0.125-0.25 g (1-2 ml of a 12.5% ​​solution) once a week. Apply only in the first half of pregnancy.
With amenorrhea (primary, secondary) is prescribed immediately after discontinuation of the use of estrogen drugs of 0.25 g, once, or in 2 administrations.
For the treatment of dysfunctional uterine bleeding the drug is less convenient than progesterone, because its effect comes slowly, but it can be used to normalize the cycle: 0.0625-0.125 g (0.5-1 ml of 12.5% ​​solution) on days 20-22 of the cycle.

Adverse reactions

Nervous system: drowsiness, headache, depression, apathy, dysphoria.
Gastrointestinal: cholestatic hepatitis, nausea, vomiting, loss of appetite, calculous cholecystitis.
From the genitourinary system: decreased libido, reduced menstrual cycle, intermediate bleeding.
Special senses: visual impairment.
From the CCC: increased blood pressure, edema, thromboembolism (including the pulmonary artery and cerebral vessels), thrombophlebitis, retinal vein thrombosis.
On the part of the endocrine system: galactorrhea, alopecia, weight gain, increase, pain and tension of the mammary glands; hirsutism. Allergic reactions.
Local reactions: soreness at the injection site.

Drug Interactions

Changes the effects of hypoglycemic agents, oral anticoagulants, corticosteroids (combined with caution). Progestin activity is reduced by inductors of microsomal oxidation (barbiturates, hydantoins, rifampicin, etc.).