Progesterone Ampoule 1% 1ml №10

Injection

Packaging

10 pieces

Mechanism of action

Progesterone - gestagen. Hormone yellow body. Causes the transition of the mucous membrane of the uterus from the phase of proliferation caused by follicular hormone to the secretory phase, and after fertilization contributes to its transition to the state necessary for the development of a fertilized egg. Reduces the excitability and contractility of the muscles of the uterus and fallopian tubes, stimulates the development of the terminal elements of the mammary gland. Does not possess androgenic activity. Progesterone has a weak effect on protein metabolism, contributes to the deposition of fat and the accumulation of glucose in the liver, and also reduces the reabsorption of sodium in the renal tubules.
Progesterone has a blocking effect on the secretion of hypothalamic factors releasing LH and FSH, inhibits the formation of gonadotropic hormones in the pituitary gland and inhibits ovulation.

Dysfunctional uterine bleeding, metrorrhagia, amenorrhea, habitual miscarriage. Contraception.

Contraindications

Severe dysfunction of the liver or kidneys, hepatitis, thromboembolic diseases, vaginal bleeding of not established genesis, carcinoma of the mammary gland (except in cases in which progesterone is used as part of a combination therapy of this disease).

Dosage and administration

V / m, adults the highest single dose of 0.025 g (2.5 ml of 1% or 1 ml of 2.5% p-ra).

Adverse reactions

Cardiovascular: possible increase in blood pressure.

Metabolism: possible swelling.

Gastrointestinal: abnormal liver function, jaundice; rarely (with prolonged use) - nausea, vomiting.

On the part of the endocrine system: rarely (with prolonged use) - decreased libido, weight gain, pain and tension in the mammary glands, irregular uterine bleeding.

From the side of the central nervous system: rarely (with prolonged use) - headache, depression.

Reduces the intensity of the action of drugs that stimulate the smooth muscles of the uterus, anabolic steroids, gonadotropic hormones of the anterior pituitary gland.
Reduces the lactogenic effect of oxytocin.
Enhances the action of diuretics, antihypertensive drugs, immunosuppressants.
At simultaneous use with barbiturates decrease in action of progesterone is noted.

In the dark place.