Utrogestan capsules 200mg №14

Packaging

14 pieces

Mechanism of action

UTROZHESTAN - gestagen, hormone of the corpus luteum. By binding to receptors on the surface of target organ cells, it penetrates into the nucleus, where, by activating DNA, it stimulates RNA synthesis. It promotes the transition of the uterine mucous membrane from the proliferation phase caused by follicular hormone to the secretory phase, and after fertilization to the state necessary for the development of a fertilized egg. Reduces the excitability and contractility of the muscles of the uterus and fallopian tubes, stimulates the development of the terminal elements of the mammary gland. Stimulating protein lipase, increases fat stores, increases glucose utilization, increases the concentration of basal and stimulated insulin, promotes the accumulation of glycogen in the liver, increases the production of aldosterone; in small doses it accelerates, and in large doses it suppresses the production of gonadotropic hormones of the pituitary; reduces azotemia, increases the excretion of nitrogen in the urine. It activates the growth of the secretory section of the mammary glands and induces lactation. Promotes the development of normal endometrium.

Indications and usage

For oral administration: premenstrual syndrome; fibrocystic mastopathy; premenopause; as a gestagen component of hormone replacement therapy in menopause (in combination with estrogen). Intravaginal: hormone replacement therapy with non-functioning (missing) ovaries in case of a complete lack of Progesterone (egg donation); support of the luteal phase during preparation for IVF, support of the luteal phase in a spontaneous or induced menstrual cycle; premature menopause, menopause and postmenopause (in combination with estrogen); prevention of habitual and threatened miscarriage, due to progestin insufficiency; endocrine sterility, prevention of uterine fibroids; endometriosis.

Contraindications

Hypersensitivity; liver failure, thrombosis, acute forms of phlebitis or thromboembolic diseases; bleeding from the genital tract of unknown origin; incomplete abortion, porphyria. C caution. Diseases of cardiovascular system, arterial hypertension, chronic renal failure, diabetes, bronchial asthma, epilepsy, migraine, depression; hyperlipoproteinemia, pregnancy (II and III trimesters), lactation period.

Dosage and Administration

The drug should be taken orally, in the evening before bedtime (not recommended to be taken before, after or during meals). With premenstrual syndrome, fibrocystic mastopathy, dysmenorrhea, premenopause - 200-300 mg for 10 days (from 17 to 26 day of the cycle); with hormone replacement therapy in menopause while taking estrogen - 200 mg / day for 10-12 days. Intravaginally, when donating eggs (on the background of estrogen therapy) - 100 mg / day for 13 and 14 days of the cycle, then 100 mg 2 times a day, from 15 to 25 days of the cycle; from day 26, and in the case of determining pregnancy, the dose increases by 100 mg / day every week, reaching a maximum of 600 mg in 3 doses (for 60 days).To support the luteal phase during the IVF cycle - 400-600 mg / day, starting from the day of injection of CG to 12 weeks of gestation. To support the luteal phase in a spontaneous or induced menstrual cycle, with infertility associated with dysfunction of the corpus luteum, 200-300 mg / day, starting from the 17th day of the cycle for 10 days; in case of delayed menstruation and diagnosis of pregnancy, treatment should be continued. With the threat or prevention of abortion - 100-200 mg 2 times a day every day, up to 12 weeks of pregnancy.

Adverse reactions

Allergic reactions, drowsiness, transient dizziness (1-3 h after administration of the drug), reduction of the menstrual cycle, intermenstrual bleeding.

Drug Interactions

Reduces the lactogenic effect of oxytocin.