Thrombone ass pills 100mg №28

Active ingredient and dosage form

Tablets, film-coated enteric-coated:
1 pill contains Acetylsalicylic acid 50 mg and 100 mg;
Excipients: lactose, microcrystalline cellulose, colloidal silicon dioxide, potato starch, talc, glycerol triacetate + poly (ethyl acrylate, methyl acrylate) (Eudragit L30D).
28 pcs. packaged.

Mechanism of action

Thrombos Ass - NSAID, antiplatelet.
Lowers blood clotting due to the reduction of platelet aggregation due to the suppression of the synthesis of thromboxane A in them₂.
The use of thrombotic ACC, starting with a dose of 50 mg, leads to a long-term decrease of 90-95% in serum concentration of thromboxane A₂ and its metabolites.
It also has anti-inflammatory, analgesic and antipyretic effect.
Tablets of the drug are coated with enteric film resistant to the action of gastric juice, thereby reducing the risk of side effects from the stomach.

Indications and usage

- primary prevention of myocardial infarction (reduction of the risk of myocardial infarction in patients with coronary artery disease);
- secondary prevention of myocardial infarction;
- prevention of cerebral circulatory disorders of the ischemic type;
- prevention of thrombosis and emboli, incl.in patients with an increased risk of their occurrence (after heart and vascular operations, coronary artery bypass surgery).

Contraindications

- erosive and ulcerative lesions of the gastrointestinal tract in the acute phase;
- increased bleeding, blood clotting, hemophilia;
- nephrolithiasis;
- "Aspirin Triad";
- hypothrombinemia;
- deficiency of glucose-6-phosphate dehydrogenase;
- lactation (breastfeeding);
- children's and teenage age up to 18 years;
- hypersensitivity to acetylsalicylic acid and its derivatives.

Dosage and administration

Assign inside 50-100 mg 1 time per day.
pills should be taken without chewing, with a small amount of liquid.
Thrombone ACC is intended for long-term use. The duration of therapy is determined individually.

Adverse reactions

Allergic reactions: bronchospasm, skin rash. In predisposed patients - provocation of attacks of bronchial asthma.
Gastrointestinal: nausea, vomiting, diarrhea.
Hemic and lymphatic: thrombocytopenia, iron deficiency anemia (due to latent bleeding from the gastrointestinal tract).
From the reproductive system: prolongation of menstruation.
With prolonged use of the drug in high doses, renal dysfunction, dizziness, tinnitus, ulcerative lesions of the gastrointestinal tract, bleeding are possible.
In general, Thrombotic ACC is well tolerated by patients (due to the low content of acetylsalicylic acid in the preparation). Side effects are noted in some cases.

Pregnancy and breastfeeding

Do not recommend the use of Thrombotic ACC in the third trimester of pregnancy, as well as the use of the drug as part of combination therapy in the I and II trimesters of pregnancy.
Thrombosis ACC is contraindicated for use during lactation (breastfeeding).

Care should be taken when prescribing the drug to patients with indications of a history of hypersensitivity reactions with the use of NSAIDs, with erosive-ulcerative and inflammatory diseases of the gastrointestinal tract outside the acute phase, with abnormal liver function and / or kidneys.
When using the drug development addiction was not observed.

Overdosage

Overdose is unlikely due to the low content of acetylsalicylic acid in the preparation.
Symptoms: nausea, vomiting, tinnitus, general malaise.
Treatment: artificial vomiting, the appointment of Activated carbon, laxatives; if necessary, conduct correction KSHR.

Drug Interactions

With the simultaneous use of Thrombotic ACC enhances the action of anticoagulants, NSAIDs, hypoglycemic agents, Methotrexate.
The combined use of Thrombone ACC with glucocorticoids and ethanol increases the likelihood of ulcerogenic action of the drug, increases the risk of Gastrointestinal bleeding.
With simultaneous use of Thrombone ACC weakens the effect of diuretics (spironolactone, furosemide) and urikozuricheskimi drugs (if necessary, the combined use of Thromboth ACC and the above preparations, the interval should be at least 1-3 hours).
Simultaneous administration of antacids has no significant effect on the bioavailability of acetylsalicylic acid.

Storage conditions

The drug should be stored in a dry, protected from light, out of reach of children at a temperature not exceeding 25 ° C.