Ibuprofen pills 200mg №20

Packaging

20 pcs.

Mechanism of action

Ibuprofen is a nonsteroidal anti-inflammatory drug, a derivative of phenylpropionic acid. It has anti-inflammatory, analgesic and antipyretic effects. The effect of the drug is due to inhibition of prostaglandin synthesis by blocking the enzyme cyclooxygenase.
Suppresses platelet aggregation. With prolonged use has a desensitizing effect.

Indications and usage

Rheumatoid arthritis, osteoarthritis, articular syndrome with exacerbation of gout, psoriatic arthritis, ankylosing spondylitis (ankylosing spondyloarthritis), cervical spondylosis, Barre-Lieu syndrome (cervical migraine, vertebral artery syndrome); neuralgia, myalgia, tendonitis, bursitis, tendovaginitis, neuralgic amyotrophy, ligamentous sprain, hematoma, sciatica, traumatic inflammation of the soft tissues and the musculoskeletal system; feverish states of various genesis (including after immunization); symptomatic treatment of influenza and ARVI; postural hypotension while taking antihypertensive drugs; nephrotic syndrome (to reduce the severity of proteinuria). As an aid: infectious and inflammatory diseases of the upper respiratory tract (tonsillitis, pharyngitis, laryngitis, sinusitis, rhinitis), bronchitis, pneumonia, inflammatory processes in the pelvis, adnexitis, primary dysmenorrhea, algomenorrhea, postoperative pain, headache and toothache, panniculitis.

Contraindications

Hypersensitivity, peptic ulcer of the stomach or duodenum (in acute stage), ulcerative colitis, diseases of the optic nerve, scotoma, amblyopia, impaired color vision, cirrhosis with portal hypertension, Aspirin asthma (triggered by ASK or other NSAIDs), heart insufficiency, edema, arterial hypertension, hemophilia, hypocoagulation, leukopenia, hemorrhagic diathesis, hearing loss, vestibular pathology, deficiency of glucose-6-phosphate dehydrogenase; pregnancy (III trimester).
With care - hyperbilirubinemia, pregnancy, lactation; peptic ulcer of the stomach and duodenum (in history), gastritis, enteritis, colitis; liver and / or renal failure, blood diseases of unknown etiology, children age (up to 12 years).

Pregnancy and Breastfeeding

In animal studies, no adverse effect of Ibuprofen on the fetus was found. Due to the lack of a sufficient number of well-controlled observations in humans, the drug should be used in the first and second trimesters of pregnancy only in cases of urgent need. Ibuprofen inhibits uterine muscle contraction. The effect of Ibuprofen on the fetus can cause premature closure of the botanal duct, which can lead to the development of pulmonary hypertension in the newborn. Do not use ibuprofen at the end (third trimester) of pregnancy. No ibuprofen excretion was detected with mother's milk. However, due to the limited scope of these studies and the possible adverse effect of inhibiting the synthesis of prostaglandins in the newborn, it is not recommended to use the drug during breastfeeding. With prolonged use of Ibuprofen, periodic monitoring of the peripheral blood pattern and the functional state of the liver and kidneys is recommended. When symptoms of gastropathy appear, close monitoring is shown, including esophagogastroduodenoscopy, a blood test with hemoglobin, hematocrit, and fecal occult blood analysis. To prevent the development of NSAID-gastropathy, it is recommended to combine Ibuprofen with PG E drugs (misoprostol).

Dosage and administration

Ibuprofen takes orally after eating.
For rheumatoid arthritis appoint 800 mg 3 times a day.
In osteoarthritis and ankylosing spondylitis Ibuprofen is used on 400-600 mg 3-4 times a day.
In juvenile rheumatoid arthritis the drug is used in a dose of 30-40 mg / kg of body weight per day.
In case of soft tissue injuries, sprains the drug is prescribed 600 mg 2-3 times a day.
When pain syndrome of moderate intensity the drug is prescribed 400 mg 3 times a day. The maximum daily dose of 2.4 g
Children over 12 years old the initial dose is 150-300 mg 3 times a day, the maximum dose is 1 g, then 100 mg 3 times a day; in juvenile rheumatoid arthritis - 30-40 mg / kg / day in divided doses.
To reduce body temperature 39.2 ° C and above - 10 mg / kg / day, below 39.2 ° С - 5 mg / kg / day.

Special notes

With caution, the drug is prescribed to patients with impaired liver, kidney, cardiovascular diseases, with a history of gastric ulcer and / or duodenal ulcer, bleeding from the gastrointestinal tract.
Compared with other NSAIDs, Ibuprofen has the least ulcerogenic effect on the gastrointestinal mucosa.
With prolonged use of the drug, it is necessary to monitor the function of the liver and / or kidneys, the picture of peripheral blood.

Drug Interactions

With the simultaneous appointment of ibuprofen may cause a decrease in the diuretic effect of Furosemide.
When combined, Ibuprofen enhances the effect of difenin, coumarin anticoagulants, oral hypoglycemic drugs.

Overdosage

In case of overdose, which is manifested in the increased signs of side effects, you should stop treatment and consult a doctor.

Store in a dry dark place out of the reach of children.