L-thyroxine pills 100mcg №50

Active ingredient

Active ingredient: levothyroxine sodium - 0.100 mg.
Excipients: Calcium hydrophosphate dihydrate - 31.90 mg, microcrystalline cellulose - 32.00 mg, sodium carboxymethyl starch (type A) - 24.00 mg, dextrin - 13.60 mg, 2.40 mg.

round, slightly convex pills of white or white with a slightly yellowish tinge, with a risk on one side and an embossed “100” on the other.

Indications and usage

hypothyroidism;
euthyroid goiter;
as a replacement therapy and for the prevention of relapse of goiter after resection of the thyroid gland;
thyroid cancer (after surgery):
diffuse toxic goiter: after reaching the euthyroid state with antithyroid drugs (as a combination or monotherapy);
 
Contraindications
Hypersensitivity to the active substance or to any of the excipients that make up the preparation (see the “Composition” section);
untreated thyrotoxicosis;
acute myocardial infarction, acute myocarditis;
untreated adrenal cortex insufficiency.

The drug should be prescribed for diseases of the cardiovascular system: ischemic heart disease (atherosclerosis, angina pectoris, myocardial infarction), arterial hypertension, arrhythmia, diabetes, severe long-term hypothyroidism, malabsorption syndrome (dose adjustment may be required).

Pregnancy and Breastfeeding

During pregnancy and breastfeeding therapy with a drug prescribed for hypothyroidism should continue. During pregnancy, an increase in the dose of the drug due to increased levels of thyroxin-binding globulin. The amount of thyroid hormone secreted in breast milk during lactation (even during treatment with high doses of the drug) is not enough to cause any disturbances in the child. The use of the drug in combination with antithyroid drugs during pregnancy is contraindicated, since taking levothyroxine sodium may require an increase in doses of antithyroid "remedies.Since antithyroid drugs, unlike levothyroxine sodium, can penetrate the placenta, hypothyroidism can develop in the fetus. During breastfeeding, the drug should be taken with caution, strictly in recommended doses under the supervision of a physician.

Dosage and administration

The daily dose is determined individually depending on the evidence. L-Thyroxin 100 Berlin-Chemie in a daily dose is taken orally in the morning on an empty stomach, or at least 30 minutes before a meal, drinking a pill with a small amount of liquid (half a glass of water) and not chewing.
When performing replacement therapy for hypothyroidism (in the absence of cardiovascular diseases), L-Thyroxin 100 Berlin-Chemie is prescribed in a daily dose of 1.6-1.8 μg / kg body weight. With significant obesity, the calculation should be done on the "ideal weight".

The initial stage of replacement therapy for hypothyroidism
Patients without cardiovascular diseases younger than 55 years old • initial dose: women - 50-100 mcg / day, men -50-150 mcg / day
patients with cardiovascular disease or over 55 years old • Initial dose - 25 mcg per day
• Increase by 25 mcg with an interval of 3-6 weeks to normalize the level of TSH in the blood
• If the symptoms of the cardiovascular system appear or worsen, correct the treatment of cardiovascular diseases

For infants and children up to 3 years of age, a daily dose of L-Thyroxine 100 Berlin-Chemie is given at one time 30 minutes before the first feeding. The pill is dissolved in water to a thin suspension, which is prepared immediately before taking the drug. In patients with severe long-term hypothyroidism, treatment should be started with extreme caution, with small doses of 25 mcg / day, the dose should be increased to maintenance at longer intervals of 25 mcg / day every 2 weeks and more often determine the concentration of TSH in the blood. In hypothyroidism, L-Thyroxin 100 Berlin-Chemie is usually taken for a lifetime. In thyrotoxicosis, L-Thyroxin 100 Berlin-Chemie is used in complex therapy with antithyroid drugs after reaching the euthyroid state. In all cases, the duration of drug treatment is determined by the doctor.
 
Side effect
With proper use under the supervision of a physician, no side effects are observed.
In case of hypersensitivity to the drug, allergic reactions may occur.

Overdosage

With an overdose of the drug, symptoms characteristic of thyrotoxicosis are observed: tachycardia, heart rhythm disturbance, heart pain, anxiety, tremor, insomnia, hyperhidrosis, loss of appetite, weight loss, diarrhea, vomiting, headache, increased fatigue, muscle spasm. Depending on the severity of symptoms, a doctor may recommend a decrease in the daily dose of the drug, a break in treatment for several days, the appointment of beta-blockers. After the disappearance of side effects, treatment should begin with caution with a lower dose. Antithyroid drugs are not recommended.

Drug interactions

Levothyroxine sodium enhances the effect of indirect anticoagulants, which may require lowering their dose.
The use of tricyclic antidepressants with levothyroxine sodium can lead to an increased effect of antidepressants.
Thyroid hormones can increase the need for insulin and oral hypo-glycemic drugs. It is recommended that more frequent monitoring of blood glucose concentrations be initiated during the period of initiation of treatment with levothyroxine sodium, as well as when changing the dose of the drug.
Levothyroxine sodium reduces the action of cardiac glycosides. With simultaneous use of colestyramine, colestipol and aluminum hydroxide reduce the plasma concentration of levothyroxine sodium due to inhibition of its absorption in the intestine. When used simultaneously with anabolic steroids, asparaginase, Tamoxifen, pharmacokinetic interaction is possible at the level of protein binding.
With simultaneous use with phenytoin, salicylates, clofibrate, Furosemide in high doses, the content of levothyroxine sodium and T4 not bound to plasma proteins increases.
Somatotropin when used simultaneously with levothyroxine sodium can accelerate the closure of the epiphyseal growth zones.
Consumption of phenobarbital, Carbamazepine and rifampicin may increase the clearance of levothyroxine sodium and require an increase in the dose.
Estrogens increase the concentration associated with thyroglobulin fraction, which may lead to a decrease in the effectiveness of the drug.
Amiodarone, aminoglutethimide, p-aminosalicylic acid (PAS), ethionamide, antithyroid drugs, beta-blockers, chloral hydrate, diazepam, levodopa, dopamine, Metoclopramide, lovastatin, somatostatin affect the synthesis, secretion, distribution, metabolism and levothyroxine sodium. Products containing soy may reduce the absorption of levothyroxine sodium (a dose adjustment may be necessary).
 
special instructions
In hypothyroidism, caused by damage to the pituitary gland, it is necessary to find out whether there is at the same time an insufficiency of the adrenal cortex. In this case, replacement therapy with glucocorticosteroids should begin before the treatment of hypothyroidism with thyroid hormones in order to avoid the development of acute adrenal insufficiency.
The influence of the drug on the ability to drive vehicles and control mechanisms

L-Thyroxine 100 Berlin-Chemie does not affect the ability to drive vehicles and work requiring increased concentration.

Tablets 100 mcg.
On 25 pills in the blister strip packaging (blister) [PVC / PVDC / aluminum foil or aluminum foil / aluminum foil].
On 1, 2 or 4 blisters together with the instruction for application are placed in a cardboard pack.

Storage conditions

Store at a temperature not higher than 25 ° С.
Keep the medicine out of the reach of children!

2 years
Do not use after the expiration date printed on the package!

On prescription.