Neurobion pills №20

Dosage form

Coated Tablets

Composition

One coated pill contains: thiamine disulfide (vitamin B₁) - 100 mg, Pyridoxine hydrochloride (vitamin B_b) - 200 mg, cyanocobalamin (vitamin B₁₂) - 240 mcg
Excipients:magnesium stearate, methylcellulose, corn starch, gelatin, lactose monohydrate, talc, wax, acacia, glycerin 85%, povidone 25, Calcium carbonate, colloidal silicon dioxide, kaolin, titanium dioxide, sucrose.

Packing

20 pcs.

Mechanism of action

The preparation Neurobion contains a combination of neurotropic active substances of a complex of Vitamins of group B. Contains vitamins: thiamine (B₁), pyridoxine (B_b) and cyanocobalamin (B₁₂) play a special role as coenzymes in the intermediate metabolism occurring in the central and peripheral nervous system.
Therapeutic Vitamin B Administration₁, AT₆ and B₁₂ compensates for the often insufficient intake of vitamins from food, which ensures the presence in the body of the necessary quantities of coenzymes. The combined use of vitamins of group B increases their therapeutic efficacy, since it is believed that the effectiveness of the combination is superior to the effectiveness of individual factors.
The therapeutic use of these vitamins in various diseases of the nervous system is aimed, on the one hand, to compensate for the existing deficit (possibly due to an increased need of the body due to the disease itself) and, on the other hand, to stimulate natural recovery mechanisms. At the same time, the analgesic effect of the vitamin B complex has a beneficial effect on the therapeutic outcome.

Indications and usage

In the treatment of the following neurological diseases:
trigeminal neuralgia
neuritis of the facial nerve
pain syndrome caused by diseases of the spine (intercostal neuralgia, lumboischialgia, lumbar syndrome, cervical syndrome, cervico-brachial syndrome, radicular syndrome caused by degenerative changes of the spine).

Contraindications

Hypersensitivity to any component of the drug Neurobion.

Pregnancy and Breastfeeding

To date, there are no data on adverse effects during pregnancy after administration of vitamins B₁, AT₆ and B₁₂ in recommended doses.

Dosage and administration

Adults and teenagers older than 15 years: 1 pill 3 times a day or as directed by a doctor. Children under 15 years: by doctor's prescription.
Tablets Neurobion taken without chewing, squeezed small amounts of water, it is better during the meal. The duration of treatment is determined by the doctor.

Adverse reactions

Possible allergic reactions, which mainly occur in the form of skin manifestations.

Special notes

With the introduction of vitamin B₁₂ the clinical picture, as well as laboratory parameters with funicular myelosis or pernicious anemia, may lose their specificity.

Drug interactions

Pyridoxine. When applied simultaneously with levodopa, vitamin pyridoxine may reduce the anti-Parkinsonian effect of levodopa.
Enhances the action of diuretics.
Isonicotine hydrazide, penicillamine, cycloserine and estrogen-containing oral contraceptives weaken the effect of pyridoxine.
It is well combined with cardiac glycosides (pyridoxine enhances the synthesis of contractile proteins in the myocardium), with glutamic acid and Asparkam (increased resistance to hypoxia).
Zinocobalamin. Aminoglycosides, salicylates. antiepileptic drugs, colchicine, potassium drugs reduce absorption.
Can not be combined with drugs that increase blood clotting. Taking B12 may mask the lack of folic acid.

Overdosage

Vitamins B₁, AT_b and B₁₂ have a wide therapeutic range.
Vitamin B₁: Overdose symptoms after oral administration have not been registered.
Vitamin B₆: In case of overdose: neuropathy with ataxia, a violation of sensitivity. cerebral seizures with changes on the ECG, as well as in some cases, hypochromic anemia and seborrheic dermatitis (were described after ingestion of more than 2 g per day).
Vitamin B₁₂: After parenteral administration of a high dose (as well as in rare cases after ingestion), allergic reactions, eczematous skin disorders and a benign form of acne were observed.

At a temperature not higher than 25 ° С, out of the reach of children.

3 years.