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Omez Insta powder for suspension 20 mg bags №5
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Powder for suspension for oral administration.
Composition
Active substance: Omeprazole 20 mg;
Excipients: sodium bicarbonate 1680 mg, xylitol 2000 mg, sucrose 2070 mg, sucralose 30 mg, xanthan gum 55 mg, mint flavor 30 mg.
Packaging
5 pieces
Mechanism of action
OMEZ INSTA is a specific proton pump inhibitor: it inhibits the activity of H + / K + -ATP-ases in the parietal cells of the stomach, blocking the final stage of secretion of hydrochloric acid, thereby reducing acid production.
Omeprazole is a prodrug and is activated in the acidic environment of the secretory tubules of the parietal cells of the stomach.
Exposure is dose-dependent and provides effective inhibition of both basal and stimulated acid secretion, regardless of the nature of the stimulating factor.
Indications and usage
- Heartburn and other symptoms associated with gastroesophageal reflux disease (GERD);
- non-erosive and erosive (reflux esophagitis) forms of GERD;
- peptic ulcer of the stomach and duodenum (including prevention of relapse);
- eradication of Helicobacter pylori in infected patients with gastric ulcer and duodenal ulcer (as part of combination therapy);
- NSAID-gastropathy;
- hypersecretory conditions (Zollinger-Ellison syndrome, stressful ulcers of the gastrointestinal tract, polyendocrine adenomatosis, systemic mastocytosis).
Contraindications
Hypersensitivity, fructose intolerance, deficiency of sucrase / isomaltase, glucose-galactose malabsorption (due to the presence of sucrose in the formulation) childhood, pregnancy, lactation period.
The drug should not be used in conjunction with atazanavir and nelfinavir.
Dosage and Administration
The drug should be taken orally, 30 minutes before meals. Pour the contents of the bag into a cup, add 1-2 tablespoons of water (do not use other liquids or foodstuffs!), Mix thoroughly until a homogeneous suspension is obtained and drink immediately. If necessary, you can drink a small amount of water.
For quick relief of heartburn symptoms, a single dose of 20 mg is sufficient.
Patients with non-erosive GERD - 20 mg 1 time / day for 4 weeks. Patients with an erosive form of GERD (reflux esophagitis) - 20 mg 2 times / day for 4-8 weeks, depending on the severity of esophagitis. For the prevention of exacerbation of reflux esophagitis - 20 mg / day, the duration of maintenance therapy is determined individually.
With the exacerbation of gastric ulcer or duodenal ulcer, not associated with Helicobacter pylori - 20 mg in the morning 1 time / day for 4-8 weeks.
For eradication of Helicobacter pylori, therapy is used in various combinations: for 7-14 days omeprazole 20 mg, Amoxicillin 1 g, Clarithromycin 500 mg - 2 times / day; or omeprazole 20 mg, clarithromycin 500 mg, Metronidazole 500 mg - 2 times / day; or omeprazole 20 mg 2 times / day, bismuth preparations at a dose of 120 mg 4 times / day, metronidazole 500 mg 3 times / day and Tetracycline 500 mg 4 times / day.
For the prevention of gastric ulcer or 12 duodenal ulcer - 20 mg in the morning 1 time / day for 4-8 weeks.
For the treatment of NSAID-gastropathy - 20 mg 2 times / day. for 4-6 weeks, for prophylaxis - 20 mg / day for the period of use of NSAIDs in patients with risk factors for the development of NSAIDs-gastropathy.
When hypersecretory conditions - 20 mg in the morning 1 time / day for 4-8 weeks.
In the treatment of Zollinger-Ellison syndrome, doses are selected individually, depending on the clinical condition. The recommended starting dose is 60 mg per day. In most patients, the condition is adequately controlled in the dose range of 20-120 mg. If you need a dose of more than 80 mg, it is necessary to divide it into 2 administrations.
In elderly patients and in renal failure there is no need to adjust the dose. In hepatic insufficiency, a daily dose of 20 mg may be sufficient.
Adverse reactions
Gastrointestinal: often - diarrhea or constipation, abdominal pain, nausea, vomiting, flatulence; rarely - increased activity of "liver" enzymes, taste disorders; very rarely - dry mouth, stomatitis, candidiasis of the gastrointestinal mucosa. in patients with previous severe liver disease, hepatitis (including jaundice); very rarely - liver failure, incl. with the development of encephalopathy (in patients with a history of liver disease).
Nervous system: often - headache; infrequently - dizziness, paresthesias, drowsiness; rarely - a violation of taste.
Psychological: infrequently - insomnia; rarely - agitation, confusion, depression; very rarely - aggression, hallucinations.
Special senses: infrequently - vertigo; rarely blurred vision.
Musculoskeletal system: rarely - arthralgia, myalgia; very rarely - muscle weakness.
From the skin: infrequently - dermatitis, itching, rash, urticaria; rarely alopecia, photosensitivity; very rarely - erythema multiforme exudative, Stevens-Johnson syndrome, toxic epidermal necrolysis.
Allergic reactions: rarely hypersensitivity reactions, including fever, angioedema, and Anaphylactic reactions (including anaphylactic shock). From the genitourinary and reproductive system: rarely - interstitial nephritis, very rarely - gynecomastia.
Metabolic disorders: rarely, hyponatremia; very rarely - hypomagnesemia. Other: infrequent - malaise, peripheral edema, rarely - bronchospasm, increased sweating.
Overdosage
Symptoms: headache, dizziness, lethargy, confusion, tachycardia, arrhythmia, blurred vision, drowsiness, dry mouth, nausea, vomiting, flatulence.
Treatment: symptomatic. If necessary - gastric lavage, Activated carbon. Hemodialysis is not effective enough.
Storage conditions
In a dry, dark place, at a temperature not higher than 25 ° C.