Kosilon Spray 2% 60ml

DOSAGE FORMS

solution for external use 2%

GROUP

Remedies for Alopecia

COMPOSITION

The active ingredient is Minoxidil.

INTERNATIONAL NON-PATENT NAME

Minoxidil

SYNONYMS

Alerana, Alopexy, Generolon, Regein

PHARMACHOLOGIC EFFECT

When external use of minoxidil, its stimulating effect on hair growth in individuals with androgenic alopecia (thinning hair, baldness) was noted. It improves microcirculation, stimulates the transition of hair cells to the active growing phase, changes the effect of androgens on the hair follicles. Reduces the formation of 5-alpha-dehydrotestosterone (possibly mediated), which plays a significant role in the formation of baldness. The best effect has a small duration of the disease (no more than 10 years), young patients, bald spot in the area of ​​the crown not more than 10 cm, the presence in the center of the baldness more than 100 vellus and terminal hair. The appearance of signs of hair growth is noted after 4 months or more of the drug. The onset and severity of the effect may vary in different patients. After the cessation of the use of the drug Kosilon, the growth of new hair stops, within 3 to 4 months it is possible to restore the original appearance. The exact mechanism of action of the drug Kosilon in the treatment of androgenetic alopecia is unknown.Minoxidil is ineffective in the case of baldness caused by taking the drug, unhealthy diet (iron deficiency (Fe), vitamin A), as a result of styling hair in "tight" hairstyle. When applied externally, Minoxidil is poorly absorbed through normal, intact skin: an average of 1.5% (0.3-4.5%) of the total applied dose enters the systemic circulation. The effect of concomitant skin diseases on the absorption of Minoxidil is unknown. After discontinuation of the drug, approximately 95% of minoxidil that has entered the systemic circulation is eliminated within 4 days. The profile of the metabolic biotransformation of minoxidil after external use of the drug Kosilon has not yet been fully studied. Minoxidil does not bind to plasma proteins and is excreted by the kidneys through glomerular filtration. Minoxidil does not penetrate the blood-brain barrier. Excreted mainly with urine. Minoxidil and its metabolites are excreted by hemodialysis.

INDICATIONS FOR USE

For the treatment of androgenic alopecia (hair restoration) and stabilization of the process of hair loss in men and women.

CONTRAINDICATIONS

Hypersensitivity to minoxidil or other components of the drug. Age under 18 years. Older age - over 65 years. Violation of the integrity of the skin, dermatosis of the scalp

SIDE EFFECT

The use of minoxidil can cause increased hair loss during the transition from the resting phase to the growth phase, with old hair falling out and new ones growing in their place.This temporary phenomenon is usually observed 2-6 weeks after the start of treatment and gradually stops over the next two weeks (the appearance of the first signs of the action of minoxidil). Side effects from external use can manifest as pruritus at the site of application, contact dermatitis, folliculitis, hypertrichosis (unwanted body hair growth, including facial hair growth in women), seborrhea. If the drug is accidentally swallowed, the following symptoms may occur: On the part of the skin: nonspecific allergic reactions (skin rash, urticaria). On the part of the respiratory system: shortness of breath, allergic rhinitis. From the nervous system: headache, dizziness, vertigo, neuritis. Since the cardiovascular system: chest pain, fluctuations in blood pressure, rapid heartbeat, a change in the rhythm of heart contractions, edema.

INTERACTION

There is a theoretical possibility of enhancing orthostatic hypotension in patients receiving concomitant treatment with peripheral vasodilators, which, however, has not received clinical confirmation. We can not exclude a very slight elevated content of minoxidil in the blood of patients suffering from hypertension and taking minoxidil orally in the case of simultaneous use of the drug Kosilon, although the corresponding clinical studies have not been conducted.It is established that minoxidil when applied topically may interact with some other drugs for external use. The simultaneous use of a solution of minoxidil for external use and a cream containing betamethasone (0.05%) leads to a decrease in systemic absorption of minoxidil. The simultaneous application to the skin of minoxidil and topical preparations, such as tretinoin and dithranol, which cause changes in the protective functions of the skin, can lead to an increase in the absorption of minoxidil.

DOSAGE AND ADMINISTRATION

For external use only. Kosilon applied only to the skin of the scalp. Do not apply Kosilon on other parts of the body. Before using the sprayer for the first time, spray the solution 2-3 times until a uniform spray is achieved. The next time the sprayer can be used immediately. Regardless of the size of the treated area, apply 1 ml of the solution using a dispenser (8 taps) 2 times a day to the affected areas of the scalp, starting from the center of the affected area. Wash hands after use. The total daily dose should not exceed 2 ml. For men, Kosilon is most effective for hair loss at the crown, for women - for hair loss in the middle parting. Apply the drug Kosilon only on dry skin of the scalp. The solution does not require rinsing.The appearance of the first signs of hair growth stimulation is possible after using the drug 2 times a day for 4 months or more. The onset and severity of hair growth, as well as the quality of hair can vary in different patients. According to single reports, within 3-4 months after cessation of treatment, the initial appearance can be restored. The duration of treatment is on average about 1 year. After clinical improvement, the dose is reduced to 1 ml solution 1-2 times a week. If after 4 months a satisfactory result is not achieved, you should consult with a dermatologist, who may decide to extend the treatment.

OVERDOSE

Accidental intake of Kosilon may cause systemic side effects due to the vasodilating properties of Minoxidil (5ml of Kosilon contains 250mg of Minoxidil, which is 2.5 times more than the maximum recommended dose for adults when taken orally in the treatment of arterial hypertension). Signs of overdose: fluid retention, lower blood pressure, tachycardia. Treatment: to eliminate fluid retention, diuretics can be prescribed if necessary; for the treatment of tachycardia - beta-blockers. For the treatment of arterial hypotension, a 0.9% solution of sodium chloride should be injected intravenously. You should not prescribe symptomatic agents, such as norepinephrine and epinephrine, with excessive cardiac stimulating activity.

SPECIAL INSTRUCTIONS

The preparation Kosilon is applied only on the dry skin of the scalp after bathing or at least 4 hours before bathing. Wash thoroughly after applying the product to the scalp. To wash the hair when using the drug Kosilon is recommended in the usual way. Hairspray and other hair care products can be used during the period of use of the drug Kosilon. Before applying hair care products, you must first apply the drug Kosilon and wait until the treated area of ​​skin is completely dry. There is no evidence that dyeing hair, performing a perm or using hair softeners may in any way reduce the effectiveness of the drug. However, to prevent possible irritation of the scalp, it is necessary to make sure that the drug was completely washed off the hair and scalp before applying these chemicals. Before you start treatment with Kosilon, patients must undergo a general examination, including the collection and examination of medical history. The physician must ensure that the scalp is healthy. If systemic side effects or severe skin reactions occur, patients should discontinue the drug and consult a doctor. The composition Kosilon includes ethyl alcohol. In case of contact with the drug on sensitive surfaces (eyes, irritated skin,mucous membranes) it is necessary to wash the area with plenty of cold water. The effect of the drug on psychomotor functions is not marked. The drug does not affect the ability to manage transport.

STORAGE CONDITIONS

At a temperature not higher than + 30C. Keep out of the reach of children!