-
Medications
- Respiratory system
- Oncology
- Increase potency
- Homeopathy
- Hemorrhoids
- Dermatology
- Antiseptics
- Antimicrobial
- Antifungal
- Allergy
- Cough and Antiviral
- Antiparasitics
- Other
- Stomach. Intestines. Liver
- Neurology
- Weight loss. Metabolic disorders
- Analgesics
- Bones & Joints
- Gynecology
- Cardiology
- Immune system
- Hormones
- Genitourinary system
- Topical medications
- Ophthalmology
-
Supplements
- Vitamins premium class Solgar (Solgar)
- Vitamins for women
- Vitamins for skin, hair, nails
- Vitamins for pregnant and lactating
- Vitamins for men
- Vitamins for children
- Vitamin E
- Vitamin D
- Vitamin C
- Vitamin and mineral complexes
- Tonic
- Restorative
- Mono-and multivitamins
- Macro and trace elements
- Iron preparations
- Hematogens
- Glucose
- Eye Vitamins
- Calcium, D3, fish oil
- Beer yeast
- Antioxidant Complexes
- Supplements for the digestive tract, liver, kidneys
- Herbals
-
Medical Supplies
-
Beauty
-
Cosmetic brands
- VELVET HANDS
- Uriage (URIAZH)
- TRANSFORMATION FORMULA (OP)
- SVR (SVR)
- Topicrem (TOPIKREM)
- Styx (Styx)
- Teana (TEAN)
- Phyto
- Nuxe
- System Four (SYSTEM 4)
- Noreva (NOREVA)
- SLEDOCID
- Shark force
- Lierac
- Laino (LENO)
- Scholl (SCHOLL)
- La Roche-Posay (LA ROSH POSE)
- Salizink (SALIZINK)
- Korff (KORFF)
- Planeta Organica (PLANET ORGANIC)
- Klorane (CLORAN)
- Olive Oil of Greece (OLIVE OIL OF GREECE)
- Ogx (OGI X)
- Institut Esthederm (ESTEDERM)
- Novosvit (Novosvit)
- Hormeta (ORMETA)
- NK №1 (PEOPLE'S COSMETICS)
- Filorga (FILORGA)
- Nivea (NIVEA)
- Elancyl (ELANSIL)
- Neutrogena (NITROGEN)
- Ducray (DUCRE)
- Biorga (BIORGA)
- NATURAL FORMULA
- Bioderma (bioderma)
- MY SUNSHINE
- Avene
- My Rose of Bulgaria (ROS OF BULGARIA)
- Algotherm (ALGOTERM)
- Mustela (9 months MUSTEL)
- Menalind (MENALIND)
- Mediva
- Maternea (MATERNEA)
- Librederm (LIBRIDERM)
- Le Petit Marseillais (LITTLE MARSEULES)
- LAURA
- LA-KRI
- Kneipp (KNIPP)
- Klerwin
- Johnson’s Baby (JONESON BABY)
- John Frieda
- isis pharma (ISIS PHARMA)
- iQ Beauty (IQ Beauty)
- HORSEPOWER
- Green Pharma (GREEN PHARMA)
- Floresan
- Fito Cosmetics (PHYTO COSMETIC)
- Fiori Dea
- Eva (EVA)
- Elfapharm (ELFA PHARM)
- Dry Dry (DRY DRY)
- Dove (DAV)
- DNC (DNC Cosmetics)
- DAY AFTER DAY
- CINOVIT
- CeraVe (CERAW)
- Bubchen (BYUBHEN)
- Boro
- Black & White (Black & White)
- Beauty Care (BISI)
- BANKA AGAFYI FOR THE BODY
- Aveeno (AVINO)
- Algel (ALGEL)
- AGAFJI RECIPES
- A-Derma (A-DERMA)
- ACTIVE MUMA
- Vitateka (VITATEKA)
- Alerana (ALERANA)
- Veet (HIIT)
- Vichy (VISHI)
- Nail care
- Lip care
- Sun Tanning
- Problem skin care
- Eyelid care
- Hand care
- Feet care
- Organic Cosmetics
- Hair care
- Lotions
- Hyaluronic acid
- Eye Creams
- Essential oils
- Value cosmetics
- Face masks
- Depilation
- Facial care
- Intimate Cosmetics
- Aromatherapy
-
Cosmetic brands
Methotrexate injection syringe 10mg/ml 2 ml №1
-
All payments are encrypted via SSL
-
Full Refund if you haven't received your order
Composition and release form
1 ml solution for injection - 10 mg; Patients in the 1 or 5 ml, in the box 1 bottle.
pharmachologic effect
Pharmacological action - antitumor, cytostatic.
Is an antimetabolite antagonist of folic acid. Inhibits dihydrofolate reductase and inhibits the formation of tetrahydrofolate, which is involved in the biosynthesis of nucleic acids (transfer of single-carbon fragments).
Pharmacodynamics
Suppresses mitosis, the growth of actively proliferating tissues (including bone marrow), inhibits the progression of tumors.
Indications drug Methotrexate-Ebeve
Acute lymphocytic leukemia, lymphogranulomatosis, head and neck cancer (squamous), lung, mammary gland; testicular and ovarian tumors; chorionepithelioma, soft tissue sarcoma, osteosarcoma, Ewing's sarcoma; retinoblastoma; trophoblastic disease (mono- and combination therapy), autoimmune diseases, psoriasis (with refractoriness to other types of treatment).
Contraindications
Hypersensitivity, abnormal liver function and kidney function; bone marrow hypoplasia, leukopenia, thrombocytopenia, anemia; infectious diseases; ulcers in the mouth and gastrointestinal tract, postoperative conditions, pregnancy, breast-feeding.
Use during pregnancy and lactation
Contraindicated.At the time of treatment should stop breastfeeding.
Side effects
Nausea, vomiting, difficulty swallowing, gingivitis, stomatitis, ulceration of the mucous membranes of the gastrointestinal tract, hemorrhages and other disorders of the digestive system and liver function, myelosuppression, immunosuppression, disorders of the genitourinary system (urinary disorders, electrolyte balance, genital function); skin manifestations (erythema, alopecia, acne, etc.); headache, convulsions and other signs of CNS damage, allergic reactions.
Dosage and administration
Inside, before eating, without chewing, drinking water; in / m, in / in (bolus, infusion), in / a, intrathecal (subarachnoid). Doses are selected individually, depending on the disease, general condition and blood picture of the patient. Doses above 100 mg / m2 body surfaces are injected only into / in a drip (solution or concentrate is pre-diluted with 5% glucose solution to a level of 10 mg (500-1000 ml) and under the protection of Calcium folinate. Intrathecal - 0.2-0.5 mg / kg (8-12) mg / m2 a) every 2-3 days; after the disappearance (or reduction) of symptoms, the interval between injections increases to 1 week, then to 1 month; prophylactic - every 6-8 weeks. In psoriasis, psoriatic arthritis, autoimmune diseases - 10–25 mg orally, weekly (it is also possible to administer intravenously or intramuscularly in the same dose); the initial dose is 2.5-5 mg, then the dose is increased to 7.5-25 mg / week (no more than 30 mg / week).
Precautionary measures
It is necessary to monitor the condition of the oral mucosa, liver and kidney function, peripheral blood.
Storage conditions of the drug Methotrexate-Ebeve
In the dark place at a temperature of no higher than 25 ° C.
Keep out of the reach of children.
The shelf life of the drug Methotrexate-Ebeve
Do not use after the expiration date printed on the package.