Buy Augmentin tablets 875mg + 125mg №14
  • Buy Augmentin tablets 875mg + 125mg №14

Augmentin pills 875mg + 125mg №14

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Active ingredient and dosage form

Coated Tablets from white to almost white, oval, with indented and "AUGMENTIN and" on one side; on a kink - from almost white to yellowish-white.
1 pill contains Amoxicillin (in the form of trihydrate) - 250 mg, clavulanic acid (in the form of potassium salt) - 125 mg;
auxiliary substances: Magnesium stearate, sodium starch glycolate type A, anhydrous colloidal silicon, microcrystalline cellulose;
Shell composition: titanium dioxide, hydroxypropylmethylcellulose (5 cps), hydroxypropylmethylcellulose (15 cps), polyethylene glycol 4000, polyethylene glycol 6000, dimethicone (silicone oil).
10 pieces. in aluminum foil blister, 2 blisters in a carton box.

Coated tablets: 1 pill contains amoxicillin (in the form of trihydrate) - 500 mg, clavulanic acid (in the form of potassium salt) - 125 mg;
7 or 10 pieces in aluminum foil blister, 2 blisters in a carton box.

Coated Tablets from white to almost white color, oval, with the letters and "А and" and and "С and" on both sides of the pill and the fault line on one side; on a kink - from almost white to yellowish-white.
 1 pill contains amoxicillin (in the form of trihydrate) - 875 mg, clavulanic acid (in the form of potassium salt) - 125 mg;
7 pieces in aluminum foil blister, 2 blisters in a carton box.

Powder for suspension for oral administration white or almost white in color, with a characteristic odor; prepared suspension of white or almost white color.
5 ml of the prepared suspension contains amoxicillin (in the form of trihydrate) - 125 mg, clavulanic acid (in the form of potassium salt) - 31.25 mg;
Excipients: Xanthan gum, aspartame, succinic acid, colloidal silicon, hydroxypropylmethylcellulose, silicon dioxide, dry orange flavoring 610271E (Tastemaker) and 9/027108 (Dragoco), dry raspberry flavoring NN07943 (Quest), dry flavoring and Light chimes and and ny; Firmenich);
11.5 g of powder in a 100 ml vial, 1 vial complete with a measuring cap in a cardboard box.

Powder for suspension for oral administration: 5 ml of the prepared suspension contains amoxicillin (in the form of trihydrate) - 200 mg, clavulanic acid (in the form of potassium salt) - 28.5 mg;
7.7 g of powder in a 70 ml vial, 1 vial complete with a measuring cap in a cardboard box.

Powder for suspension for oral administration: 5 ml of the prepared suspension contains amoxicillin (in the form of trihydrate) - 400 mg, clavulanic acid (in the form of potassium salt) - 57 mg;
12.6 g of powder in a bottle of 70 ml, 1 bottle complete with a measuring cap in a cardboard box.

Powder for solution for intravenous administration from white to almost white.
1 bottle contains amoxicillin (in the form of trihydrate) - 500 or 1000 mg, clavulanic acid (in the form of potassium salt) - 100 or 200 mg, respectively;
10 bottles in a carton box.

- tab. shell, 500 mg + 125 mg: - P №011997 / 01-2000 06.06.05PR
- tab.shell, 250 mg + 125 mg; 875 mg + 125 mg: - P No. 0105030 / 02-2003 30.06.03
- powder d / prigot. suspen d / ingestion 125 mg + 31.25 mg / 5 ml: - P No. 0105030 / 01-2003 03.06.03
- powder d / prigot. suspen d / ingestion 200 mg + 28.5 mg / 5 ml; 400 mg + 57 mg / 5 ml: - P No. 0155030 / 04.09.09.03
- powder d / prigot. p-ra d / in / in the introduction of 500 mg + 100 mg, 1 g + 200 mg: - P №015030 / 03-2003 30.06.03

Mechanism of action

Combined broad-spectrum antibiotic, resistant to the action of b-lactamase, containing amoxicillin and clavulanic acid.
Amoxicillin is a semi-synthetic broad-spectrum antibiotic that is active against many gram-positive and gram-negative microorganisms. Amoxicillin is destroyed by b-lactamases, therefore microorganisms producing b-lactamase are not included in the spectrum of its antibacterial activity.
Clavulanic acid, a b-lactam compound, has the ability to inactivate a wide range of b-lactamases, enzymes that usually produce microorganisms that are resistant to penicillins and cephalosporins.
The presence of clavulanic acid in Augmentin composition protects amoxicillin from the destructive action of b-lactamase and expands the spectrum of its antibacterial activity with the inclusion of microorganisms, usually resistant to other penicillins and cephalosporins.
Augmentin effective against gram-positive aerobic microorganisms: Bacillis anthracis*, Corynebacterium spp., Enterococcus faecalis*, Enterococcus faecium*, Listeria monocytogenes, Nocardia asteroides, Staphylococcus aureus*, coagulase-negative staphylococci (including Staphylococcus epidermidis), Streptococcus spp. (including Streptococcus agalactiae, Streptococcus pneumoniae, Streptococcus pyogenes, Streptococcus viridans); for gram-positive anaerobic microorganisms: Clostridium spp., Peptococcus spp., Peptostreptococcus spp.; for gram-negative aerobic microorganisms: Bordetella pertussis, Brucella spp., Escherichia coli*, Gardnerella vaginalis, Haemophilus influenzae*, Helicobacter pylori, Klebsiella spp.*, Legionella spp., Moraxella catarrhalis* (Branhamella catarrhalis), Neisseria gonorrhoeae*, Neisseria meningitidis*, Pasteurella multocida, Proteus mirabilis*Proteus vulgaris*, Salmonella spp.*, Shigella spp.*, Vibrio cholerae, Yersinia enterocolitica*; for gram-negative anaerobic microorganisms: Bacteroides spp*. (including Bacteroides fragilis), Fusobacterium spp.*; for other microorganisms: Borrelia burgdorferi, Chlamydiae, Leptospira icterohaemorrhagiae, Treponema pallidum.
* Some strains of these types of bacteria produce b-lactamase, which causes resistance to amoxicillin monotherapy.

Indications and usage

Infectious and inflammatory diseases caused by microorganisms sensitive to the drug:
- infections of the upper respiratory tract and upper respiratory tract (including recurrent tonsillitis, sinusitis, otitis media), usually caused by Streptococcus pneumoniae, Haemophilus influenzae and Moraxella catarrhalis and Streptococcus pyogenes;
- lower respiratory tract infections: exacerbations of chronic bronchitis, lobar pneumonia and bronchopneumonia, usually caused by Streptococcus pneumoniae, Haemophilus influenzae and Moraxella catarrhalis;
- infections of the urinary tract: cystitis, urethritis, pyelonephritis, infections of the female genital organs, usually caused by species of the family Enterobacteriaceae (mainly Escherichia coli), Staphylococcus saprophyticus and species of the genus Enterococcus, as well as gonorrhea caused by Neisseria gonorrhoeae;
- infections of the skin and soft tissues, usually caused by Staphylococcus aureus, Streptococcus pyogenes and species of the genus Bacteroides;
- infections of bones and joints: osteomyelitis, usually caused by Staphylococcus aureus, with the need for long-term therapy;
- other mixed infections, such as septic abortion, obstetric sepsis, intra-abdominal infections.

Contraindications

- jaundice or abnormal liver function in the history of Augmentin's use;
- hypersensitivity to beta-lactam antibiotics (including penicillins and cephalosporins).
Carefully should be used for infectious mononucleosis, pregnancy, lactation, gastrointestinal diseases (including if there is a history of indications of transferred colitis associated with the use of penicillins), chronic renal failure.

The dosage regimen is set individually depending on the age, body weight, renal function of the patient, as well as the severity of the infection.
For optimal absorption and reduction of possible side effects from the digestive system, Augmentin is recommended to be taken at the beginning of a meal.
Treatment should not be continued for more than 14 days without revising the clinical situation.
If necessary, it is possible to conduct stepwise therapy (at the beginning of the intravenous injection of the drug with the subsequent transition to oral administration).
Adults and children over 12 years old or with a body weight of more than 40 kg
1 pill (875 mg + 125 mg) 2 times / day or 1 pill (500 mg + 125 mg) 3 times / day.
Children under 12 years old
The dose, depending on age and body weight, is indicated in mg / kg of body weight per day, or in ml of suspension.
The recommended dosing regimen: 45 mg / kg / day in 2 doses or 40 mg / kg / day in 3 doses. The multiplicity of reception depends on the form of release.
Children weighing 40 kg or more the drug should be prescribed in the same doses as adults.
Single doses of the drug Augmentin, depending on age and body weight are presented in the table.


Age

Body mass

2 times / day

3 times / day

Up to 1 year2-5 kgSuspension 200 mg * / 5 ml 1.5 - 2.5 mlSuspension 125 mg * / 5 ml 1.5 - 2.5 ml
6-9 kgSuspension 200 mg * / 5 ml 5 mlSuspension 125 mg * / 5 ml 5 ml
1-5 years10-18 kgSuspension 400 mg * / 5 ml 5 mlSuspension 125 mg * / 5 ml 10 ml
6-9 years19-28 kgSuspension 400 mg * / 5 ml - 7.5 ml or 1 pill 500 mg + 125 mgSuspension 125 mg * / 5 ml - 15 ml or 1 pill 250 mg + 125 mg
10-12 years29-39 kgSuspension 400 mg * / 5 ml - 10 ml or 1 pill 500 mg + 125 mgSuspension 125 mg * / 5 ml - 20 ml or 1 pill 250 mg + 125 mg
Adults and children over 12 years oldMore than 40 kg1 pill 875 mg + 125 mg1 pill 500 mg + 125 mg

* Amoxicillin
Two tablets of Augmentin (250 mg + 125 mg) are not equivalent to one pill (500 mg + 125 mg), since the content of clavulanic acid in them is 2 times higher.
For the correct dosing volume of suspension at children under 3 months It is recommended to use a syringe with a graduation.
For the convenience of receiving children under 2 years the suspension can be diluted twice with water.
At treatment of infections of the skin and soft tissues, as well as recurrent tonsillitis the drug can be administered at a dose of 20 mg / kg / day in 3 doses (suspension 4: 1) and 25 mg / kg / day in 2 doses (suspension 7: 1).
If the frequency of excretion of pneumococcus with a high level of penicillin resistance (with penicillin BMD 2-4 mg / l) in the region (or closed institution) exceeds 10%, amoxicillin / clavulanate (Augmentin) should be used in a dose of 80-90 mg / kg / day, divided for 3 doses.
Optimum dosage form Augmentina for children from 6 to 12 years Tablets are 500 mg + 125 mg taken 2 times / day.
Patients with impaired renal function
Dose adjustment is based on the maximum recommended dose of amoxicillin and is based on the values ​​of QC.
Adults

QC

Augmentin dosing regimen

and> 30 ml / min

No dose adjustment required

10-30 ml / min

1 tab. 500 mg + 125 mg 2 times / day or 1 tab. 250 mg + 125 mg (with mild to moderate infection) 2 times / day

and 30 ml / min.
Children

appoint 15 mg + 3.75 mg / kg 1 time / day.
Before a hemodialysis session, one additional dose of 15 mg + 3.75 mg / kg should be administered. To restore the concentration of Augmentin active ingredients in the blood, a second additional dose of 15 mg + 3.75 mg / kg should be administered after a hemodialysis session.
Patients with impaired liver function
The treatment is carried out with caution; monitor liver function regularly. Not enough data to correct the dosage regimen for this category of patients.
Elderly patients
Reduce the dose Augmentina not required; doses are the same as for adults. Have elderly patients with impaired renal function dose should be adjusted as described above for adults with impaired renal function.
Suspension method
Suspension is prepared immediately before the first application. The powder should be dissolved with boiled water, cooled to room temperature, gradually shaking and adding water to the mark on the bottle. Then let stand for about 5 minutes to ensure complete dissolution. The bottle should be shaken well before each use. For the exact dosage of the drug, use a measuring cap-cap, which should be rinsed well with water after each use. After dilution, the suspension should be stored for no more than 7 days in the refrigerator, but not frozen.

IN / INJECTION
The dose depends on age, body weight, kidney function and the severity of the infection.
Doses Augmentina expressed as the content of amoxicillin to the content of clavulanic acid.
Adults
Standard dose: 1000/200 mg every 8 hours
Severe infections: 1000/200 mg every 4-6 hours.
Prevention of surgical infections for operations lasting less than 1 hour: 1000/200 mg during induction anesthesia. For operations lasting more than 1 hour: 1000/200 mg during induction anesthesia in combination with the introduction of up to 4 doses of 1000/200 mg per 24 hours.
Obvious signs of infection during surgery require the appointment of a standard course of Augment therapy in the postoperative period, either in the form of intravenous injection or for oral administration.
At renal dysfunction Augmentin dosing regimen set on the basis of the maximum dose of amoxicillin, which can be used to reduce renal function in each case. Correction of the dosing regimen is carried out depending on the CC.


QC

Dose adjustment

and> 30 ml / min

Not required

10-30 ml / min

1000/200 mg starting dose, then 500/100 mg 2 times / day

and 30 ml / min

Not required
10-30 ml / min

25/5 mg / kg 2 times / day
and 10%), often (and> 1% and and 0.1% and and 0.01% and and
Augmentin