Adepress pills 20mg №30

Release form

Coated Tablets

Composition

1 tab. contains paroxetine (in the form of hemihydrate hydrochloride) 20 mg;
excipients: Calcium hydrophosphate (calcium phosphate disubstituted), corn starch, sodium carboxymethyl starch (primogel), Magnesium stearate

Packaging

30 pieces

pharmachologic effect

Adepress - antidepressant. It is a selective serotonin reuptake inhibitor (5-hydroxytryptamine, 5-HT) brain neurons, which determines its antidepressant effect and effectiveness in the treatment of obsessive-compulsive (OCD) and panic disorder.

Paroxetine has a low affinity for m-cholinergic receptors (has a weak anticholinergic effect), α1, α2 and β-adrenergic receptors, as well as dopamine (D2), 5HT1-like, 5HT2-like and histamine H1-receptors. Paroxetine does not violate the psychomotor functions and does not potentiate the inhibitory effect of ethanol on them.

According to the study of behavior and EEG in paroxetine, weak activating properties are detected when it is prescribed in doses higher than those necessary for inhibiting serotonin uptake. In healthy volunteers, it does not cause a significant change in the level of blood pressure, heart rate and EEG.

Indications

Depression of all types, including reactive, severe endogenous depression and depression,accompanied by anxiety;
Obsessive Compulsive Disorder (OCD);
Panic disorder, incl. with fear of being in a crowd (agoraphobia);
Social anxiety disorder / social phobia;
Generalized anxiety disorder;
Posttraumatic stress disorder.

Contraindications

Simultaneous administration of MAO inhibitors and a period of 14 days after their withdrawal;
Unstable epilepsy;
Pregnancy and lactation (breastfeeding);
Childhood;
Hypersensitivity to the drug.

Carefully: in liver failure, renal failure, angle-closure glaucoma, prostatic hyperplasia, mania, cardiac pathology, epilepsy, convulsive states, simultaneous administration of electropulse therapy, simultaneous administration of drugs that increase the risk of bleeding, the risk factors for increased bleeding and diseases that increase the risk of bleeding, as well as elderly patients.

Dosage and administration

Tablets Adepress take 1 time / day, in the morning, during meals, without chewing, drinking water.

The dose is adjusted individually during the first 2-3 weeks after the start of therapy and, if necessary, adjusted later. The effect in most cases develops gradually. The dose should be increased by 10 mg every week to achieve a therapeutic effect. The maximum daily dose should not exceed 60 mg / day.

For renal and / or liver failure, the recommended dose is 20 mg / day.

For elderly patients, the daily dose should not exceed 40 mg.

To prevent recurrence, maintenance therapy is necessary. After the disappearance of the symptoms of depression, this course may be 4-6 months, and for obsessive and panic disorders - more than 4-6 months.

Avoid abrupt withdrawal of the drug. In order to prevent the development of withdrawal syndrome, discontinuation of the drug Adepress should be carried out gradually.

Side effects

Nervous system:often - drowsiness or insomnia, tremor, asthenia, dizziness, anxiety; sometimes - confusion, hallucinations, extrapyramidal disorders, paresthesias, reduced ability to concentrate; rarely - cramps, mania; very rarely - serotonin syndrome (agitation, hyperreflexia, diarrhea), panic disorders.
Special senses: in some cases - visual impairment, mydriasis.
Musculoskeletal system: rarely - myasthenia, myoclonia, arthralgia, myalgia.
Urogenital: frequent urination; rarely - urinary retention.
From the reproductive system:ejaculatory disorders, libido disorders; rarely - hyperprolactinemia / galactorrhea, anorgasmia.
Gastrointestinal:loss of appetite, nausea, vomiting, dry mouth; sometimes constipation or diarrhea; in some cases - hepatitis.
Cardiovascular: orthostatic hypotension.
Allergic reactions:rarely - rash, urticaria, ecchimatosis, pruritus, angioedema.
Other:increased sweating; in rare cases - hyponatremia, a violation of the secretion of antidiuretic hormone.

special instructions

In order to avoid the development of neuroleptic malignant syndrome with caution should be appointed Adepress patients taking neuroleptics.

In elderly patients, while receiving Adepress, hyponatremia is possible.

In some cases, it is necessary to adjust the dose of simultaneously used insulin and / or oral hypoglycemic drugs.

With the development of seizures, treatment with Adepress is stopped.

At the first signs of mania, the drug should be discontinued.

During the first few weeks of treatment with Adepress, the patient’s condition should be closely monitored for possible suicidal attempts.

During therapy Adepressom should refrain from taking alcohol in connection with the strengthening of its toxic effect.

Influence on ability to drive motor transport and control mechanisms
Despite the fact that paroxetine does not impair cognitive and psychomotor functions, patients should refrain or exercise extreme caution when driving and when engaging in other potentially hazardous activities that require increased concentration and psychomotor reactions.

Storage conditions

Store in a dry place inaccessible to children at a temperature not exceeding 25 ° C.