Magnemax pills 500mg №20

Trade name

Magnemaks

Dosage Form

Pills

Composition

1 pill contains:

active substance:magnesium orotate dihydrate 500 mg;

Excipients: lactose monohydrate, corn starch, microcrystalline cellulose, povidone K-30, croscarmellose sodium, colloidal silicon dioxide (aerosil), sodium cyclamate, talc, Magnesium stearate.

Description

Round flat-cylindrical pills of white or almost white color with a facet and risky.

Pharmacotherapeutic group

Magnesium drug

Pharmacological properties

Pharmacodynamics

The drug is magnesium. Magnesium is an essential trace element, is involved in the implementation of more than 300 enzymatic reactions, regulation of cell permeability and neuromuscular excitability. Necessary to ensure many energy processes, is involved in the metabolism of proteins, fats, carbohydrates and nucleic acids. Magnesium has a curare-like effect on the terminations of cholinergic neurons, with a decrease in acetylcholine release. Magnesium and Calcium interact in the body partially synergistically: nevertheless, with competitive inhibition of calcium, magnesium can also affect binding sites as a “physiological calcium antagonist”.

Pharmacokinetics

Approximately 35-40% of the accepted dose is absorbed. Hypomagnesemia stimulates the absorption of magnesium ions. The presence of orotic acid salts improves the absorption of magnesium.

Magnesium is excreted by the kidneys, excretion decreases with magnesium deficiency and increases with its excess.

Indications for use

Established magnesium deficiency, isolated or associated with other deficient conditions, accompanied by symptoms such as increased irritability, minor sleep disorders, gastrointestinal spasms, fatigue, muscle pain and spasms, tingling sensation in the muscles. If after a month of treatment there is no reduction of these symptoms, the continuation of treatment is inappropriate.

Contraindications

Hypersensitivity to the components of the drug, urolithiasis, renal dysfunction, susceptibility to the formation of calcium-magnesium-ammonium phosphate stones, liver cirrhosis with ascites.

Children's age up to 18 years.

The drug contains lactose, so you should not use it in patients with lactose intolerance, lactase deficiency or glucose-galactose malabsorption.

Use during pregnancy and during breastfeeding

Application during pregnancy is possible only according to the recommendation of the doctor. Magnesium passes into breast milk. It is necessary to avoid the use of the drug during breastfeeding.

Use of the drug during pregnancy and lactation is possible if the potential benefit to the mother outweighs the potential risk to the fetus and child.

Dosage and administration

Inside, before eating, squeezed a small amount of liquid.

Assign 2 pills 3 times a day for 7 days, then 1 pill 2-3 times daily. Duration of treatment is 4 weeks.

Side effect

From the gastrointestinal tract: unstable stools and diarrhea, which usually pass on their own when the dose of the drug is reduced.

Immune system: allergic reactions.

Overdose

With normal kidney function, ingestion of magnesium does not cause toxic reactions. Magnesium poisoning can develop in renal failure. Toxic effects mainly depend on serum magnesium concentration.

Symptoms: decrease in blood pressure, nausea, vomiting, depression, slow reflexes, respiratory depression, coma, cardiac arrest, anuric syndrome.

Treatment: rehydration, forced diuresis. In renal insufficiency, hemodialysis or peritoneal dialysis is necessary.

Interaction with other drugs

At the same time taking magnesium-containing preparations with preparations of iron, sodium fluoride and tetracyclines may decrease the absorption of the latter. In addition, aminoquinolines, quinidine, penicillamine should not be administered simultaneously with magnesium preparations. Therefore, you should take these drugs with an interval of 2-3 hours.

Oral contraceptives, diuretics, muscle relaxants, glucocorticosteroids, insulin, reduce the effect of the drug.

Magnesium should be used with caution if you are taking magnesium-containing drugs, such as antacids or laxatives, or potassium-saving diuretics or drugs containing calcium.With simultaneous use with preparations containing aluminum, the absorption of aluminum in the body can be increased.

Magnesium should be used with caution when used in combination with digitalis preparations, since simultaneous use may interfere with the absorption of digitalis preparations.

Some antibiotics (aminoglycosides), Cisplatin and cyclosporin A can cause increased excretion of magnesium.

Some diuretics (thiazides and furosemide), cetuximab and erlotinib, proton pump inhibitors (omeprozole and pantoprazole), foscarnet, pentamidine, rapamycin and amphotericin B can cause magnesium deficiency, and thus reduce the effect of the drug.

special instructions

The drug contains lactose monohydrate, so its use is not recommended for patients with hereditary galactosemia, malabsorption of glucose and galactose and lactase deficiency.

Influence on ability to drive vehicles and mechanismsThe drug does not affect the ability to drive vehicles, mechanisms and engage in other activities that require high concentration of attention and speed of psychomotor reactions.

Storage conditions

At a temperature not higher than 25 ^aboutWITH.

Keep out of the reach of children.

Shelf life

Do not use after the expiration date.

Vacation conditions

Let go without a prescription.