Elidel Cream 1% 30g

Means for external use. Pimecrolimus is a derivative of macrolactam ascomycin. Selectively inhibits the production and release of cytokines and mediators from T-lymphocytes and mast cells. It has anti-inflammatory properties.

Pimecrolimus binds specifically to macrophilin-12 and inhibits calcium-dependent phosphatase calcineurin. As a result, blocking the transcription of early cytokines, pimecrolimus suppresses the activation of T-lymphocytes. In particular, at nanomolar concentrations, pimecrolimus inhibits the synthesis of interleukin-2, Interferon gamma (Th1 type), interleukin-4 and interleukin-10 (Th2 type) in human T-lymphocytes. In addition, in vitro, after interaction with the antigen / IgE complex, pimecrolimus prevents antigen / IgE-mediated release of cytokines and inflammatory mediators from mast cells. Pimecrolimus does not affect the growth of keratinocytes, fibroblasts and endothelial cells.

Pimecrolimus is effective in skin inflammation, but at the same time its effect on the systemic immune response is very small. In general, the uniqueness of the mechanism of action of pimecrolimus consists in the combination of anti-inflammatory activity, selective to the skin, with a low ability to induce systemic immune responses.

Indications

Atopic dermatitis (eczema).

The drug is indicated for short-term and long-term use in adults, as well as in children (aged 3 months) and adolescents.

Dosage and administration

In adults and children older than 3 months, used externally 2 times / day.

Side effect

Often: burning sensation at the site of application of the cream.

Often: local reactions (irritation, itching and redness of the skin), skin infections (folliculitis).

Possible: suppuration, worsening of the course of the disease, herpes simplex, dermatitis caused by the herpes simplex virus (herpes eczema), molluscum contagiosum; local reactions such as rash, pain, paresthesia, peeling, dryness, swelling, skin papillomas, boils.

In rare cases: alcohol intolerance (immediately after ingestion of alcohol, redness of the face, rash, burning, itching, or swelling were usually observed).

Contraindications

Hypersensitivity to pimecrolimus.

Use in children

It is used in children older than 3 months according to the dosing regimen.

Special notes

Do not apply on affected skin with acute viral infection.

In the case of bacterial or fungal skin lesions, use is possible after curing the infection.

Since compatibility studies have not been carried out, it is not recommended to be used together with other local means.