Cyprinol pills 500mg №10

Pills

Composition

Ciprofloxacin

Excipients: sodium carboxymethyl starch, anhydrous colloidal silicon dioxide, croscarmellose sodium, Magnesium stearate, povidone, microcrystalline cellulose.

Packing

10 pieces

Mechanism of action

CYPRINOL is a broad-spectrum antimicrobial agent from the group of fluoroquinolones. Bactericidal effect. Inhibits the DNA-enzyme enzyme of bacteria, as a result of which DNA replication and the synthesis of bacterial cellular proteins are violated. Ciprofloxacin acts both on reproducing microorganisms and on microorganisms that are in the resting phase.

A drug active against gram-negative bacteria: Escherichia coli, Salmonella spp., Shigella spp., Citrobacter spp., Klebsiella spp., Enterobacter spp., Proteus mirabilis, Proteus vulgaris, Serratia marcescens, Hafnia alvei, Edwardsiella tarda, Providencia spp., Morgan and friend, business, business, business, business, business, business, business, business, business, business, name, class, name, name, class, name, class, name, name, name, name spp., Haemophilus spp., Pseudomonas aeruginosa, Moraxella catarrhalis, Aeromonas spp., Pasteurella multocida, Plesiomonas shigelloides, Campylobacter jejuni, Neisseria spp.; intracellular microorganisms: Legionella pneumophila, Brucella spp., Chlamydia trachomatis, Listeria monocytogenes, Mycobacterium tuberculosis, Mycobacterium kansasii, Mycobacterium avium-intracellulare; Gram-positive bacteria: Streptococcus spp. (including Streptococcus pyogenes, Streptococcus agalactiae), Staphylococcus spp. (including Staphylococcus aureus, Staphylococcus haemolyticus, Staphylococcus hominis, Staphylococcus saprophyticus). Most methicillin resistant staphylococci are also resistant to ciprofloxacin.

To drug moderately sensitive Streptococcus pneumoniae, Enterococcus faecalis.

To drug are resistant Corynebacterium spp., Bacteroides fragilis, Pseudomonas cepacia, Pseudomonas maltophila, Ureaplasma urealyticum, Clostridium difficile, Nocardia asteroides.

The effect of the drug on Treponema pallidum is not well understood.

Upon admission Ziprinol there is no development of parallel resistance to other antibiotics that do not belong to the group of inhibitors of gyrase, which makes it highly effective against bacteria that are resistant to aminoglycosides, penicillins, cephalosporins, tetracyclines.

Indications and usage

Infectious and inflammatory diseases caused by susceptible microorganisms, including:

- respiratory tract infections;

- infections of the ear, nose and throat;

- infections of the kidneys and urinary tract;

- genital infections (gonorrhea, prostatitis, adnexitis, postpartum infections);

- infections of the digestive system (including the mouth, teeth, jaws), gallbladder and biliary tract;

- infections of the skin, mucous membranes and soft tissues;

- infections of the musculoskeletal system;

- sepsis;

- peritonitis;

- prevention and treatment of infections in patients with reduced immunity (during therapy with immunosuppressants).

Contraindications

- pseudomembranous colitis (for iv injection);

- deficiency of glucose-6-phosphate dehydrogenase (for iv administration);

- pregnancy;

- lactation period (breastfeeding);

- children's and teenage age up to 18 years;

- hypersensitivity to ciprofloxacin or other drugs from the group of fluoroquinolones.

WITH caution prescribe the drug for atherosclerosis of the cerebral vessels, disorders of cerebral circulation, mental illness, epilepsy, convulsive syndrome, severe renal or hepatic insufficiency, elderly patients.

Dosage and administration

The dosage regimen is set individually, depending on the location and severity of the infection, the state of the body, age, body weight, and the kidney function of the patient.

At uncomplicated kidney and urinary tract diseases the drug is prescribed 250 mg 2 times / day., with complicated - 500-750 mg 2 times / day.

At lower respiratory diseases - 250 mg 2 times / day., in severe cases - 500-750 mg 2 times / day.

At treatment of gonorrhea the drug is prescribed once in a dose of 250-500 mg.

At enteritis, severe colitis, gynecological infections, prostatitis, osteomyelitis - 500-750 mg 2 times / day.

For diarrhea treatment - 250 mg 2 times / day.

For prevention of surgical infections - 500-750 mg every other day.

The duration of treatment depends on the severity of the disease.

Adverse reactions

Gastrointestinal: nausea, vomiting, diarrhea, pseudomembranous colitis, flatulence, loss of appetite, cholestatic jaundice (especially in patients with previous liver diseases), hepatitis, hepatonecrosis, increased activity of hepatic transaminases, alkaline phosphatase, LDH, bilirubin.

Nervous system: headache, dizziness, fatigue, anxiety, tremor, increased intracranial pressure, peripheral paralgesia, insomnia, nightmarish dreams, confusion, depression, hallucinations and other manifestations of psychotic reactions (occasionally progressing to conditions in which the patient can harm himself), fainting, migraine, cerebral artery thrombosis.

Special senses: impaired taste and smell, visual impairment (diplopia, change in color perception), tinnitus, hearing loss.

Cardiovascular: tachycardia, cardiac arrhythmias, hypotension, hot flashes (with a / in the introduction).

Hemic and lymphatic: eosinophilia, leukopenia, thrombocytopenia, neutropenia; with on / in the introduction of granulocytopenia, anemia, thrombocytosis, hemolytic anemia.

Musculoskeletal system: rarely - arthritis, tendovaginitis, tendon rupture; arthralgia, myalgia (with a / in the introduction).

Urogenital: crystalluria, interstitial nephritis, glomerulonephritis, dysuria, polyuria, albuminuria, hematuria, increased urea levels, creatinine; urinary retention, reduced kidney nitrogen excretion.

Allergic reactions: pruritus, urticaria, angioedema, Stevens-Johnson syndrome, arthralgia; vasculitis, erythema nodosum, exudative erythema multiforme, Lyell syndrome (with a / in the introduction).

Adverse reactions associated with chemotherapeutic action: candidiasis.

Other: general weakness, photosensitivity; increased sweating, hyperglycemia (with a / in the introduction).

Local reactions: with a / in the introduction - pain and burning, phlebitis.

Drug Interactions

With simultaneous use Ziprinol with didanosine, absorption of ciprofloxacin is reduced due to the formation of ciprofloxacin complexes with didanosine magnesium and aluminum salts.

Due to a decrease in the activity of microsomal oxidation processes in hepatocytes, ciprofloxacin increases the concentration and increases the half-life of theophylline and other xanthines.

With simultaneous use of ciprofloxacin and oral hypoglycemic drugs, indirect anticoagulants, a decrease in the prothrombin index.

With the simultaneous use of ciprofloxacin and NSAIDs (excluding acetylsalicylic acid) increases the risk of seizures.

Simultaneous administration of antacids, as well as preparations containing ions of aluminum, zinc, iron, and magnesium, may cause a decrease in the absorption of ciprofloxacin, therefore the interval between administration of these drugs must be at least 4 hours.

With simultaneous use of ciprofloxacin and cyclosporine increases the nephrotoxic effect of the latter.

Metoclopramide accelerates the absorption of ciprofloxacin, which leads to a decrease in the time to reach its maximum plasma concentration.

Co-administration of uricosuric drugs leads to a slower elimination (up to 50%) and an increase in the plasma concentration of ciprofloxacin.

When combined with other antimicrobial agents (beta-lactam antibiotics, aminoglycosides, Clindamycin, metronidazole), synergism is usually observed. Tsiprinol^® can be used in combination with azlocillin and ceftazidime for infections caused by Pseudomonas spp.; with mezlocillin,azlocillin and other beta-lactam antibiotics - for streptococcal infections; with isoxazolpenicillins and Vancomycin - for staphylococcal infections; with Metronidazole and clindamycin - for anaerobic infections.

Treatment: specific antidote is unknown. It is shown gastric lavage, monitoring the condition of the patient, if necessary, carry out symptomatic therapy. It is necessary to ensure adequate intake of fluid in the body. Using hemodialysis or peritoneal dialysis, a small amount of ciprofloxacin (less than 10%) can be inferred.

At a temperature not higher than 25 ° С.