Yarin pills №21x3

Indications and usage

Hormonal contraception.
The drug is recommended for use in acne and seborrhea, as well as hormone-dependent fluid retention in the body.

Dosage and administration

Yarin drug should be taken on 1 tab. / Day continuously for 21 days.
pills should be taken in the order indicated on the packaging, every day at about the same time, with a small amount of water.
Reception of each next package begins after a 7-day break, during which there is withdrawal bleeding (menstrual-like bleeding), which usually starts 2-3 days after taking the last tab.and may not end before taking the drug from the new package. Taking the pills from the next pack should be started on the 8th day, even in cases when the bleeding continues. Consequently, each new package is started on the same day of the week, and withdrawal bleeding will begin around the same day of the month.

In the absence of taking any hormonal contraceptives in the previous month Reception Yarin begin on day 1 of the menstrual cycle (ie, on day 1 of menstruation), while taking a pill, labeled with the corresponding day of the week. It is allowed to start taking on the 2-5 day of the menstrual cycle, but in this case it is recommended to use a barrier method of contraception during the first 7 days of taking the pills from the first package.

When switching from combined oral contraceptives reception Yarina should begin the day after taking the last tab. with the active components of the previous drug, but in no case no later than the next day after the usual 7-day break in the reception (for drugs containing 21 tab.) or after taking the last inactive tab. (for preparations containing 28 tab. in the package).

When moving from contraceptives containing only gestagens ("mini-pili")Yarina can begin to apply without interruption.

When using injection forms of contraceptives or implants They start taking Yarina from the day when the next injection should be done or on the day of the implant removal.In all cases, you must use an additional barrier method of contraception during the first 7 days of taking pills.

When taking the drug Yarin after childbirth you should wait until the end of the first normal menstrual cycle and take the drug according to the recommended scheme. You must use an additional barrier method of contraception during the first 7 days of taking pills. If a woman lived in sexual life between the birth and the beginning of the reception of Yarina, then you should first exclude pregnancy.
Changes in dosing regimen
If the time for taking the next pill is missed, missed pill a woman should take as soon as possible, take the next pill at the usual time.
If the delay in taking the pill is less than 12 hours, the reliability of contraception is not reduced.
If the delay in taking the pills is more than 12 hours, the reliability of contraception can be reduced. It should be borne in mind that taking pills should never be interrupted for more than 7 days, and that 7 days of continuous taking the drug are required to achieve adequate suppression of the function of the hypothalamic-pituitary-ovarian system.
If the delay in taking the pills was more than 12 hours (the interval from the moment of taking the last pill is more than 36 hours) during first and second week taking the drug, then the woman should take the missed tab. as soon as possible, as soon as he remembers (even if it means taking two pills at the same time).The next pill is taken at the usual time. Additionally, you should use a barrier method of contraception for the next 7 days. If a woman had sex life for a week before skipping a pill, it is necessary to consider the possibility of developing pregnancy. The more pills are missed, and the closer this pass to the 7-day break in taking pills, the higher the probability of pregnancy.
If the delay in taking the pills was more than 12 hours (the interval from the moment of taking the last pill is more than 36 hours) during time of the third week taking the drug, then the woman should take the missed tab. as soon as possible, as soon as he remembers (even if it means taking two pills at the same time). The next pill is taken at the usual time. Additionally, you should use a barrier method of contraception for the next 7 days. In addition, taking the drug from a new package should be started as soon as the current package is finished, i.e. nonstop. Most likely, the woman will not have withdrawal bleeding until the end of the second package, but she may have spotting or breakthrough uterine bleeding on the days of taking the drug.
If a woman misses a pill, and then at the first normal free drug interval she has no withdrawal bleeding, it is necessary to exclude pregnancy.
If a woman had vomiting within 3 to 4 hours after taking Yarina, the absorption of the active substances may be incomplete. In this case, you need to focus on the recommendations when skipping pills.If a woman does not want to change the normal mode of taking the drug, she should take an additional pill (or several pills) from another package if necessary.
In order to delay the onset of menstruation, the woman should continue taking the pill from the new Yarina package immediately after taking all the pills from the previous one, without interruption in the intake. pills from this new package can be taken as long as the woman wants (until the package is finished). While taking the drug from the second package, a woman may have spotting or breakthrough uterine bleeding. Resume taking Yarin from the next new package should be after the usual 7-day break.
In order to postpone the beginning of menstruation to another day of the week, a woman should shorten the next break in taking the drug for as many days as she wants. The shorter the interval, the higher the likelihood that she will not have withdrawal bleeding, and there will be spotting and breakthrough bleeding during the second package (just as if she would like to delay the onset of menstruation).

Adverse reactions

Gastrointestinal: nausea, vomiting.
From the reproductive system: changes in vaginal secretion.
On the part of the endocrine system: engorgement, tenderness of the mammary glands, secretion from them; change in body weight, change in libido.
From the side of the central nervous system: decrease in mood, headache, migraine.
Other: various skin reactions, poor tolerance to contact lenses, fluid retention in the body, allergic reactions.

- the presence of thrombosis (venous and arterial) at present or in history (for example, deep vein thrombosis, pulmonary embolism, myocardial infarction, cerebrovascular disorders);
- the presence at present or in the history of conditions preceding thrombosis (for example, transient disturbances of cerebral circulation, angina);
- diabetes with vascular complications;
- the presence of severe or multiple risk factors for venous or arterial thrombosis;
- the presence at the present time or in the history of severe forms of liver diseases (until the liver test values ​​are normalized);
- the presence at present or in the history of benign or malignant tumors of the liver;
- identified hormone-dependent malignant diseases of the genital or mammary glands or suspicion of them;
- severe or acute renal failure;
- vaginal bleeding of unknown origin;
- pregnancy or suspicion of it;
- lactation (breastfeeding);
- hypersensitivity to the drug.

Special notes

Before starting the drug, it is necessary to conduct a general medical examination (including mammary glands) and cytological examination of cervical mucus, exclude pregnancy, disorders of the blood coagulation system. With prolonged use of the drug, prophylactic control examinations should be carried out every 6 months.
If there are risk factors, you should carefully evaluate the potential risk of taking and discuss it with a woman before she decides to start taking the drug. When weighting, amplification, or at the first manifestation of risk factors may require the abolition of the drug.
Care should be taken when prescribing Yarina to patients with diabetes, obesity, high blood pressure, valvular heart disease, severe heart rhythm disorders, phlebitis of superficial veins, varicose veins, thrombosis, myocardial infarction or stroke in a family history, migraine , epilepsy, hyperkalemia, hypercholesterolemia or hypertriglyceridemia in history (including family history), in breast history in the family history, in diseases of the liver or gall bladder, in Crohn's disease or UC, with systemic lupus erythematosus, sickle cell anemia, hemolytic uremic syndrome.
The risk of venous thrombosis increases with age, with obesity, with thrombosis in history (including family), with an increase in the number of cigarettes smoked per day, as well as during operations or prolonged immobilization.
When using Yarina, smoking should be stopped, especially for women over 35 years old.
In rare cases, against the background of the use of sex hormones, the development of liver tumors was observed.In cases of enlarged liver, the appearance of severe abdominal pain or signs of intraperitoneal bleeding, this should be taken into account when conducting a differential diagnosis.
The relationship between the development of cervical cancer, breast cancer and taking combined oral contraceptives has not been proven.
The patient should be informed that if symptoms of venous or arterial thrombosis develop, one should immediately consult a doctor. These symptoms include a sudden onset of cough, sudden severe chest pain with or without irradiation to the left hand, any unusual, severe, prolonged headache, increased frequency and severity of migraine, partial or complete loss of vision, diplopia, insensible speech or aphasia, sudden changes in hearing, smell, taste, dizziness or fainting, weakness or a very significant loss of sensation that suddenly appeared on one side or in one part of the body, one-sided pain in the leg and / or swelling, severe disorders, acute abdomen symptom complex.
It should be borne in mind that while receiving Yarina, chloasma may develop, especially in women with a history of pregnant chloasma. This category of patients should avoid UV radiation.
While taking the drug, occasional bleeding can sometimes occur (spotting or breakthrough bleeding), especially during the first months of treatment.Therefore, any irregular bleeding should be assessed only after an adaptation period of approximately 3 cycles.
If irregular bleeding recurs or develops after previous regular cycles, non-hormonal causes should be considered and adequate diagnostic measures taken to exclude malignant neoplasms or pregnancy. These may include diagnostic curettage.
In some cases, during a break in taking pills, withdrawal bleeding may not develop. If the drug was taken as recommended, it is unlikely that the woman is pregnant, but if you take pills irregularly or in the absence of two menstrual bleeding in a row, pregnancy should be excluded before continuing to take the drug.

Symptoms: nausea, vomiting, vaginal bleeding.
Treatment: conduct symptomatic therapy. There is no specific antidote.

With the simultaneous use of anticonvulsants (primidone, Carbamazepine , hydantoin, barbiturates), anti-TB drugs (rifampicin), ampicillin, tetracyclines, Griseofulvin can reduce the contraceptive efficacy of Yarin.
When combined use of Yarin with ACE inhibitors, angiotensin II receptor antagonists, potassium-saving diuretics, aldosterone antagonists,Indomethacin has a theoretical possibility of developing hyperkalemia.

The drug should be stored at a temperature not higher than 25 ° C.

- 3 years.