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Latin name

MILARENA

Release form

Tablets, film coated from white to almost blue color, round, biconvex; The core is from white to almost white.

Mechanism of action

adaptogenic.

Indications

desynchronosis (disruption of the normal circadian rhythm): due to the rapid movement between the time zones of the Earth; in violation of the light mode, incl. for people engaged in shift or shift work;

meteosensitivity;

fatigue, sleep disorders (including in elderly patients).

Contraindications

hypersensitivity to melatonin and other components of the drug;

autoimmune diseases, allergies;

Hodgkin's disease, leukemia, lymphoma, myeloma, epilepsy, diabetes mellitus, chronic renal failure;

pregnancy, lactation;

children's age (efficiency and safety of use are not established).

Use during pregnancy and lactation

The drug is contraindicated for use during pregnancy and lactation (breastfeeding).

Special notes

During the period of use of the drug is recommended to avoid exposure to bright light.

It is necessary to inform women who want to become pregnant about the presence of a weak contraceptive effect.

Influence on ability to steer vehicles, mechanisms. During the period of treatment, care must be taken when driving and engaging in other potentially hazardous activities that require increased concentration and psychomotor speed.

Composition

1 tab. melatonin 3 mg

Excipients: Calcium hydrophosphate dihydrate - 64.67 mg, microcrystalline cellulose - 25 mg, croscarmellose sodium - 2 mg, povidone K25 - 3.33 mg, colloidal silicon dioxide - 0.5 mg, talc - 1 mg, calcium stearate -0.5 mg.

Shell composition: 3 mg: hypromellose - 62.5%, macrogol 400 - 12.5%, titanium dioxide - 24.21%, aluminum lacquer FD and C blue No. 2 (12-14%) - 0.28%, aluminum lacquer FD and C blue No. 1 (11-13% ) - 0.48%, quinoline yellow lacquer - 0.02%, iron dye black oxide - 0.01%.

Dosage and administration

Inside

In case of sleep disturbance, desynchronosis, fatigue, the dose is adjusted individually and is 0.3-3 mg 1 time per day 30-40 minutes before sleep.

When meteosensitivity - 0.3 mg 1 time per day for 30-40 minutes before sleep.

The duration of treatment is determined individually (from 2 to 8 weeks). Repeat courses are possible.

When used as an adaptogen when changing time zones - 1 day before the flight and for the next 2-5 days - 3 mg 30-40 minutes before sleep.

The maximum daily dose is 6 mg.

Side effects

Allergic reactions to the components of the drug, headache, nausea, vomiting, diarrhea, morning drowsiness, swelling (usually in the first week of admission) are possible.

Drug interaction

Incompatible with MAO inhibitors, corticosteroids, cyclosporine. Enhances the effect of drugs that inhibit the central nervous system and beta-blockers. Not recommended simultaneous reception with NSAIDs.

Overdosage

There are no data on cases of overdose of melatonin. There is evidence of the use of melatonin in a daily dose of up to 300 mg without clinically significant side effects.

Treatment: gastric lavage, symptomatic therapy.