Actovegin pills 200mg №50

Mechanism of action

The drug, which activates the metabolism in tissues, improves trophism and stimulates the regeneration process. The active substance is a deproteinized calf-blood hemoderivate with low molecular weight peptides and derivatives of nucleic acids. Actovegin activates cellular metabolism by increasing the transport and accumulation of glucose and oxygen, increasing intracellular utilization. These processes lead to an acceleration of ATP metabolism and an increase in the energy resources of the cell. Under conditions that limit the normal functions of energy metabolism (hypoxia, lack of substrate), and with increased energy consumption (healing, regeneration) Actovegin stimulates the energy processes of functional metabolism and anabolism. The secondary effect is increased blood supply.
In case of disorders of metabolism and blood supply to the brain, for example, in cerebral insufficiency syndrome (dementia), glucose transfer through the BBB and its cell utilization worsens. Pyruvate dehydrogenase activity and acetylcholine concentration are also reduced. The use of Actovegin contributes to the normalization of these indicators, improves the transport and utilization of glucose, while an increase in oxygen consumption is observed.Actovegin has been shown to act in the same way for peripheral (arterial, venous) circulatory disorders and the corresponding consequences of such disorders (arterial angiopathy, ulcers of the lower extremities).
The use of Actovegin to accelerate wound healing is also based on the properties described above. The drug is particularly effective in accelerating the healing of ulcers of various etiologies, trophic disorders (bedsores), burns and radiation injuries. At the same time, not only morphological, but also biochemical parameters of granulation are improved, for example, the concentration of DNA, hemoglobin and hydroxyproline increases.
The effect of the drug Actovegin begins to appear no later than 30 minutes (10-30 minutes) after parenteral administration or oral administration and reaches a maximum after an average of 3 hours (2-6 hours).
In elderly patients, in newborns, in patients with renal or hepatic insufficiency, no decrease in the pharmacological efficacy of the drug was found.

Using pharmacokinetic methods, it is impossible to study the pharmacokinetic characteristics (absorption, distribution, elimination) of the active ingredients of the drug Actovegin, since it consists only of the physiological components that are usually present in the body.

Indications and usage

- metabolic and vascular disorders in the brain (including cerebral insufficiency syndrome, ischemic strokes, traumatic brain injury);
- peripheral (arterial and venous) vascular disorders and their consequences (arterial angiopathy, leg ulcers);
- wound healing (ulcers of various etiologies, trophic disorders / bedsores /, secondary healing processes);
- skin transplantation;
- thermal and chemical burns;
- radiation damage to the skin, mucous membranes, nervous tissue;
- hypoxia and ischemia of various organs and tissues.

Doses and method of administration depend on the nosological form and severity of the disease.
Inside appoint 1-2 pills 3 times / day before meals. Drops are not chewed, washed down with a small amount of water.
For in / in or in / a depending on the severity of the disease, the initial dose of the drug in the form of an injection solution is 10–20 ml. Then appoint 5 ml / slowly or intramuscularly 1 time / day daily or several times a week.
In / in drip or in / and jet injected solution for infusion with sodium chloride 20%, solution for infusion with sodium chloride 10%, solution for infusion 10% with dextrose.
At disorders of blood supply and metabolism of the brain at the beginning, 250-500 ml / day i.v. is introduced for 2 weeks, then 250 ml i.v. several times a week for at least 4 weeks.
At ischemic stroke Injected 250-500 ml IV daily or several times a week for about 2-3 weeks.
At arterial angiopathy enter 250 ml in / and and in / in daily or several times a week; the duration of therapy is about 4 weeks.
At trophic and other sluggish ulcers, burns Inject 250 ml IV daily or several times a week, depending on the rate of healing, in addition to local therapy with Actovegin.
With the aim of prevention and treatment of radiation lesions of the skin and mucous membranes an average of 250 ml is administered intravenously a day before the start and every day during radiation therapy, as well as within 2 weeks after it ends.
Rules for the introduction of solutions
Actovegin solutions for infusions with sodium chloride 20% and 10% and with dextrose 10% are intended for intravenous drip or jet injection.
Before starting Actovegin infusion, you must ensure the integrity of the vial.
The solution for infusion is administered in a dose of 250 ml. The initial dose can be increased to 500 ml. The infusion rate is about 2 ml / min. To achieve the desired effect may require 10-20 infusions. During infusion, care must be taken to ensure that the solution does not enter extravascular tissues.

Adverse reactions

Allergic reactions: rarely (with indications in the history of hypersensitivity reactions) - urticaria, feeling hot, increased sweating, swelling, fever.

Contraindications

- Hypersensitivity to the drug.

Pregnancy and breastfeeding

It is possible to use the drug Actovegin orally or parenterally during pregnancy and lactation according to indications.

Special notes

Parenteral administration of Actovegin should be carried out with caution because of the possible development of Anaphylactic reactions.
V / m, you can enter no more than 5 ml, since the solution has hypertonic properties.
With the development of allergic reactions introduction of Actovegin should be discontinued. If necessary, conduct standard therapy of allergic reactions (antihistamines and / or corticosteroids). In severe anaphylactic reactions, appropriate emergency treatment is carried out (administration of plasma substitutes, high-dose corticosteroids, catecholamines).
Infusion solution has a slightly yellowish tint. The color intensity may vary from one batch to another, depending on the characteristics of the raw materials used, but this does not adversely affect the activity of the drug or its tolerance. After opening the vial, the solution cannot be stored and used stored solution.
Control of laboratory parameters
With repeated parenteral administration of the drug, the electrolyte composition of the serum and the water balance of the body should be monitored.
AT experimental studies Actovegin has not been shown to cause toxic effects and adverse reactions even at doses that are 30–40 times higher than the dose for humans.

Overdosage

Currently, cases of overdose Actovegin were reported.

Drug Interactions

Drug interaction drug Actovegin not installed.
Due to possible pharmaceutical incompatibility, prevent mixing of Actovegin infusion solutions with other drugs.

Storage conditions

Pills forte should be stored at room temperature (not above 25 ° C). Shelf life - 3 years.
Injection solution should be stored in a dark place at room temperature (not above 25 ° C). Shelf life - 5 years.
Solutions for infusions with sodium chloride 10% and 20% should be stored in a dark place at a temperature of 18 ° to 25 ° C. Shelf life - 5 years.
Solution for infusions with dextrose 10% should be stored in a dark place at a temperature of 18 ° to 25 ° C. Shelf life - 3 years.