Seroquel prolong the pills 200mg №60

Tablets of the prolonged action, film coated

Composition

1 pill contains Quetiapine (as fumarate) 200 mg

Packing

60 pcs.

Mechanism of action

Antipsychotic. Seroquel Prolong has a higher affinity for serotonin 5HT2 receptors compared to dopamine D1 and D2 receptors in the brain, as well as a high affinity for histamine and alpha1 adrenergic receptors.

Indications and usage

Schizophrenia, including:
Relapse prevention in stable patients.
Bipolar disorders, including:
Moderate and severe manic episodes in the structure of bipolar disorder.
Severe episodes of depression in the structure of bipolar disorder.
Prevention of relapses of bipolar disorders in patients with previous effective Quetiapine therapy for manic or depressive episodes in the structure of bipolar disorder.

Contraindications

Hypersensitivity to any of the components of the drug.
Lactase deficiency, glucose-galactose malabsorption and galactose intolerance.
Combined use with cytochrome P450 inhibitors, such as antifungal drugs of the azole group, Erythromycin, Clarithromycin and nefazodone, as well as protease inhibitors.
Although the efficacy and safety of Seroquel Prolong in children and adolescents aged 10-17 years have been studied in clinical studies, the use of Seroquel Prolong in patients under the age of 18 years has not been shown.

Pregnancy and Breastfeeding

The use of Seroquel Prolong is possible if the expected effect of therapy outweighs the potential risk to the fetus. At the time of treatment should stop breastfeeding.

Dosage and administration

Seroquel Prolong should be taken once a day, separate from meals. pills need to be swallowed whole - do not divide, do not chew or break.
Treatment of schizophrenia, moderate and severe manic episodes in the structure of bipolar disorder

Seroquel Prolong should be taken at least 1 hour before meals. The daily dose for the first 2 days of therapy is: 1st day - 300 mg, 2nd day - 600 mg. The recommended daily dose is 600 mg, but if necessary it can be increased to 800 mg / day. Depending on the clinical effect and individual tolerance by the patient, the dose may vary from 400 to 800 mg / day. For maintenance therapy in schizophrenia does not require dose adjustment after relief of exacerbation.

Treatment of depression episodes in the structure of bipolar disorder

Seroquel Prolong should be taken at bedtime. The daily dose for the first 4 days of therapy is: 1st day - 50 mg, 2nd day - 100 mg, 3rd day - 200 mg, 4th day - 300 mg. The recommended daily dose is 300 mg.Depending on the clinical effect and individual tolerance of the patient, the dose may be increased to 600 mg. The advantages of using the drug Seroquel Prolong in a daily dose of 600 mg compared to 300 mg have not been identified. Seroquel Prolong in a dose exceeding 300 mg should be prescribed by a physician experienced in the treatment of bipolar disorders.

Prevention of relapses of bipolar disorders in patients with previous effective Quetiapine therapy for manic or depressive episodes in the structure of bipolar disorder

For the prevention of relapses of manic, depressive and mixed episodes in bipolar disorders in patients with a positive response to treatment with Seroquel Prolong, therapy should be continued in the same daily dose as at the beginning of therapy. Seroquel Prolong should be taken at bedtime. Depending on the clinical effect and individual tolerance by the patient, the dose can vary from 300 to 800 mg / day. For maintenance therapy, it is recommended to use the minimum effective dose of Seroquel Prolong.

Transfer from taking Seroquel to taking Seroquel Prolong
For convenience of admission, patients currently receiving fractional therapy with Seroquel can be transferred to receive Seroquel Prolong once a day at a dose equivalent to the total daily dose of Seroquel. In some cases, you may need a dose adjustment.

Adverse reactions

Since the cardiovascular system and blood (hematopoiesis, hemostasis): orthostatic hypotension, hypertension, tachycardia, leukopenia.

From the nervous system and sensory organs: drowsiness, dizziness, anxiety, rarely - neuroleptic malignant syndrome.

On the part of metabolism: an increase in cholesterol, serum triglycerides, ALT and AST, changes in the level of liver enzymes.

On the part of the digestive tract: dry mouth, diarrhea or constipation, dyspepsia.

For the skin: rash, dry skin.

Others: pain syndrome (abdominal pain, headache, lower back, muscles, chest, ear), asthenia, rhinitis, urinary tract infections, fever, weight gain.

Special notes

Seroquel Prolong should be used with caution in elderly patients, especially at the beginning of therapy. Selection of an effective dose of Seroquel Prolong in the elderly may be slower, and the daily therapeutic dose is lower than in younger patients. The average plasma clearance of quetiapine in elderly patients is 30% -50% lower compared with younger patients. In elderly patients, the initial dose of Seroquel Prolong is 50 mg / day. The dose can be increased by 50 mg / day until an effective dose is reached, depending on the clinical response and the tolerability of the drug by the individual patient.

For patients with renal insufficiency, dose adjustment is not required.

Quetiapine is extensively metabolized in the liver.As a consequence, caution should be exercised when using the drug Seroquel Prolong in patients with liver failure, especially at the beginning of therapy. It is recommended to start therapy with Seroquel Prolong with a dose of 50 mg / day and increase the dose daily by 50 mg until the effective dose is reached.

Drug Interactions

Does not cause the induction of the enzyme systems of the liver involved in the metabolism of phenazone. Inducers of liver microsomal systems (phenytoin and others), thioridazine increase the clearance of quetiapine, reduce inhibitors of liver microsomal systems; at the same time, simultaneous administration of quetiapine and antidepressants - imipramine (CYP2D6 inhibitor) or Fluoxetine (CYP3A4 inhibitor and CYP2D6 inhibitor) has no significant effect on its pharmacokinetics. CNS depressant drugs and ethanol increase the risk of side effects.

Storage conditions

In a dry, dark place at a temperature of no higher than 20 ° C.