Panum pills 40mg №20

Indications

- peptic ulcer of the stomach and duodenum (in acute phase), including associated with Helicobacter pylori;

- erosive gastritis;

- Gastroesophageal reflux disease;

- reflux esophagitis;

- Zollinger-Ellison syndrome;

- stressful ulcers of the digestive tract

Dosage and administration

It is applied inside. The pill does not chew, drank a small amount of liquid.

At gastric ulcer and duodenal ulcer, gastroesophageal reflux disease the daily dose is 40 mg once, possibly increasing the dose to 80 mg / day. The duration of treatment for duodenal ulcer is 14 days (sometimes the drug is used for an additional 2 weeks), for stomach ulcers and gastroesophageal reflux disease it is 4 weeks (in some cases the drug is used for 4 more weeks).

At of combined eradication antihelicobacter therapy in patients with peptic ulcer or duodenal ulcer the drug is administered 40 mg 2 times / day (before breakfast and before dinner or during meals) in combination with Amoxicillin, Azithromycin, Clarithromycin, Metronidazole. The duration of eradication therapy is 7 days (maximum 2 weeks).

Adverse effects

On the part of the digestive system: diarrhea; rarely - dry mouth, increased appetite, nausea, belching, vomiting, flatulence, abdominal pain, constipation, increased transaminase activity.

From the side of the central nervous system and sensory organs: headache; rarely, asthenia, dizziness, drowsiness, insomnia; in some cases - nervousness, depression, tremor, paresthesia, photophobia, visual disturbances, tinnitus.

From the genitourinary system: in rare cases - hematuria, edema, impotence.

From the skin: in rare cases - alopecia, acne, exfoliative dermatitis.

Allergic reactions: seldom - rash, urticaria, itching, angioedema.

Other: rarely - hyperglycemia, myalgia; in rare cases - fever, eosinophilia, hyperlipoproteinemia, hypercholesterolemia.

Contraindications

- dyspepsia neurotic genesis;

- Malignant diseases of the digestive tract;

- severe liver failure;

- hypersensitivity to the drug.

WITH caution Pantoprazole is prescribed in patients with impaired liver function, in childhood (there is no experience with the use of the drug in children under 6 years of age).

Use during pregnancy and lactation

The drug can be used during pregnancy only under strict indications, if the benefits to the mother outweigh the potential risk to the fetus.

When prescribing the drug during lactation, it is necessary to resolve the issue of stopping breastfeeding.

Application for violations of the liver

WITH caution Pantoprazole is prescribed in patients with impaired liver function.

Contraindicated in severe liver failure.

In severe hepatic impairment, the dosing regimen should be adjusted: 40 mg 1 time every 2 days, under the control of the level of liver enzymes (if they are increased, the drug is withdrawn).

Application for violations of kidney function

In case of impaired renal function, it is not recommended to exceed the dose of 40 mg / day.

Use in children

WITH caution Pantoprazole is prescribed in children (there is no experience of using the drug in children under 6 years of age).

Use in elderly patients

Older patients are not recommended to exceed the dose of 40 mg / day.

Special notes

Before treatment, malignant diseases of the esophagus and stomach should be excluded (symptomatic improvement may delay the correct diagnosis and treatment).

The diagnosis of gastroesophageal reflux disease must be endoscopically confirmed.

In elderly patients and in violation of kidney function, it is not recommended to exceed the dose of 40 mg / day.

In severe hepatic impairment, the dosing regimen should be adjusted: 40 mg 1 time every 2 days, under the control of the level of liver enzymes (if they are increased, the drug is withdrawn).

Overdosage

Symptoms of an overdose of pantoprazole are not described.

Drug interaction

Pantoprazole reduces the effect of drugs absorbed at acidic pH values ​​(including ketoconazole).

It does not affect the pharmacokinetic parameters of drugs metabolized by the enzyme system of cytochrome P450, such as Phenazepam, diazepam, Digoxin, theophylline, Carbamazepine, Diclofenac, Naproxen, pyroxicam, phenytoin, Warfarin, Nifedipine, Metoprolol, ethanol.

Does not affect the effectiveness of hormonal contraceptives.

Terms and conditions of storage

List B.Store out of reach of children at a temperature not exceeding 30 ° C in a dry, dark place.