Cordiamine 25% bottle 30ml

Mechanism of action

Analeptichesky agent of the mixed type of action (stimulation of the central nervous system, direct and reflex excitation of the respiratory and vasomotor centers). The mechanism of action consists of two components: central and peripheral. The central mechanism is associated with a direct effect on the vasomotor center of the medulla oblongata, leading to its excitation and mediated increase in systemic blood pressure (especially when initially oppressed by this center). The peripheral component of the mechanism of action is associated with the excitation of the carotid sinus chemoreceptors, which leads to an increase in the frequency and depth of respiratory movements. No effect on CCC.

Absorption - high, does not depend on the route of administration. It is rapidly metabolized in the liver to form inactive metabolites. Excretion, mainly by the kidneys.

Collapse, asphyxia (including newborns), shock states, circulatory disorders in infectious diseases, poisoning with hypnotics, narcotic analgesics, barbiturates.

Contraindications

Hypersensitivity, predisposition to convulsions, epilepsy, epileptic seizures (in history), hyperthermia in children, pregnancy.

Inside: adults - 15-40 drops 2-3 times a day, children - the number of drops equal to the number of years, children (10 years) - 10 drops 2-3 times a day. P / c, in / m, in / in: adults - 1-2 ml 2-3 times a day. Higher doses for adults: single - 2 ml, daily - 6 ml. Introduction to the vein is done slowly. In case of poisoning with drugs, hypnotics, analgesics - 3-5 ml. P / to and / m injection painful. To reduce pain, you can pre-enter procaine. Children - s / c, 0.1-0.75 ml, depending on age.

Adverse reactions

Anxiety, muscle twitching (starting with circular muscles of the mouth), flushing of the skin of the face, itching of the skin, vomiting, arrhythmias; infiltration and soreness at the injection site, allergic reactions. Overdose: tonic-clonic convulsions.

Special notes

There is no information about the safety of use in pregnant women.

Drug Interactions

Enhances the effects of psychostimulants, antidepressants. The effect is reduced by PAS, opiniazid, phenothiazine derivatives and general anesthetics. Reduces the effect of narcotic analgesics, hypnotic drugs, antipsychotics, anxiolytics, antiepileptic drugs. Convulsive action enhances reserpine.