Enam pills 10 mg №20

Indications and usage

Arterial hypertension (including renovascular), chronic heart failure (as part of combination therapy).

Contraindications

Hypersensitivity, bilateral narrowing of the renal artery or narrowing of the artery of a single kidney, angioedema, pregnancy, breast-feeding, child age.

Adverse reactions

Enam is generally well tolerated and in most cases does not cause adverse reactions requiring discontinuation of the drug.

From the side of the central nervous system: in 2-3% of cases - headache, dizziness, fatigue.

On the part of the respiratory system: in less than 2% of patients - dry cough, shortness of breath.

On the part of the digestive tract: nausea, diarrhea; rarely - pancreatitis, liver failure, dyspeptic disorders, dry mouth, abdominal pain.

Cardiovascular: arterial hypotension, syncope; very rarely - cardiac arrhythmia, angina.

Laboratory tests: proteinuria, hyperkalemia, increased activity of liver transaminases, increased bilirubin concentration in the blood, neutropenia, decreased hemoglobin, hematocrit and / or leukocytes.

Allergic reactions: skin rash; in some cases - angioedema of the face, larynx.

Very rarely: when used in high doses - insomnia, increased nervous irritability, depression, imbalance, paresthesia, tinnitus, hair loss, hot flashes, glossitis, impotence; in patients with autoimmune diseases - agranulocytosis.

Dosage and administration

Enam is taken orally, regardless of meal times.

For patients not receiving diuretics, the recommended initial dose of Ename is 5 mg / day, then the dose is selected individually, usually 10-40 mg / day in 1 or 2 doses.

Patients receiving diuretics in order to prevent arterial hypotension 1-2 days prior to the appointment of diuretic therapy should be canceled. If diuretic cannot be discontinued, the recommended initial dose of Enama is 2.5 mg.

In chronic heart failure, it is better to start treatment with a dose of 2.5 mg 1 time per day (under constant control of blood pressure), then 2.5 mg 2 times per day for 3-4 days.

Starting from 2 weeks, the dose of Enam, if necessary, is increased to 10 mg once a day, by 3-4 weeks the dose is increased to 20 mg in 1 or 2 doses, if BAP is not less than 100 mm Hg. st.

Selection of the dose and further treatment can be carried out on an outpatient basis, it is necessary to evaluate the patient's condition at least 1 time per month (only when selecting the dose, examination and monitoring of the doctor is required every 10 days), to monitor the content of creatinine and electrolytes in the blood.The presence of arterial hypotension to 80/60 mm Hg. st. against the background of maintenance therapy in the absence of complaints in the patient is not a reason for the abolition of Enam.

Storage conditions

The drug should be stored out of reach of children at a temperature not higher than 15 ° C. Shelf life - 3 years.