Amoxicillin granules for suspension 250mg/5ml bottle 100ml

Mechanism of action

Broad-spectrum antibiotic from the group of semi-synthetic penicillins. Bactericidal effect. Active against gram-positive cocci - Staphylococcus spp. (with the exception of strains producing penicillinase), Streptococcus spp. It is also active against gram-negative aerobic microorganisms: Neisseria gonorrhoeae, Neisseria meningitidis, Escherichia coli, Shigella spp., Salmonella spp., Klebsiella spp. To Amoxicillin resistant microorganisms that produce penicillinase.
In combination with Metronidazole, it is active against Helicobacter pylori. Amoxicillin is believed to inhibit the development of metronidazole resistance by Helicobacter pylori.

Infectious and inflammatory diseases caused by microorganisms susceptible to amoxicillin, including: bronchitis, pneumonia, angina, pyelonephritis, urethritis, gastrointestinal infections, gynecological infections, infections of the skin and soft tissues, listeriosis, leptospirosis, gonorrhea.
In combination with metronidazole: chronic gastritis in the acute phase, peptic ulcer and duodenal ulcer in the acute phase associated with Helicobacter pylori.

Individual. For oral administration, a single dose for adults and children over 10 years old (with a body weight of more than 40 kg) is 250-500 mg, with a severe course of the disease - up to 1 g.For children aged 5-10 years, a single dose is 250 mg; between the ages of 2 and 5 years old - 125 mg; for children under 2 years of age, the daily dose is 20 mg / kg. For adults and children, the interval between doses is 8 hours. When treating acute uncomplicated gonorrhea, 3 g once (in combination with probenecid). In patients with impaired renal function with a CC of 10–40 ml / min, the interval between doses should be increased to 12 hours; when QA is less than 10 ml / min, the interval between doses should be 24 hours.
For parenteral use in adults w / m - 1 g 2 times / day, in / in (with normal kidney function) - 2-12 g / day. Children i / m - 50 mg / kg / day, single dose - 500 mg, the frequency of administration - 2 times / day; in / in - 100-200 mg / kg / day. Patients with impaired renal function, the dose and the interval between injections should be adjusted in accordance with the values ​​of QC.

Adverse reactions

Allergic reactions (urticaria, erythema, angioedema, rhinitis, conjunctivitis; rarely - fever, joint pain, eosinophilia; extremely rare - anaphylactic shock). Superinfection may develop (especially in patients with chronic diseases or low body resistance).
When used in combination with metronidazole, nausea, vomiting, anorexia, diarrhea, constipation, epigastric pain, glossitis, stomatitis are possible; rarely - hepatitis, pseudomembranous colitis, allergic reactions (urticaria, angioedema), interstitial nephritis, disorders of hemopoiesis. With prolonged use of high doses - dizziness, ataxia, confusion, depression, peripheral neuropathy, convulsions.

Contraindications

Infectious mononucleosis.Hypersensitivity to penicillins, cephalosporins.
For use in combination with metronidazole: diseases of the nervous system; blood disorders, lymphocytic leukemia, infectious mononucleosis; pregnancy, lactation, hypersensitivity to nitroimidazole derivatives.

With caution used in patients prone to allergic reactions.
Amoxicillin in combination with metronidazole is not recommended for use in patients younger than 18 years; should not be used for gastrointestinal diseases with prolonged diarrhea or vomiting, as well as liver disease. Against the background of combination therapy with metronidazole, alcohol is not recommended.