Vitaprost plus rectal candles №10

Dosage form

rectal suppository

Composition

1 rectal suppository contains:
Substance "Samprost" (in terms of 20% of the content of water-soluble peptides) 100 mg.
Lomefloxacin hydrochloride 400 mg.

Excipients:Witepsol.

Packaging

10 pieces

Mechanism of action

VITAPROST PLUS - Vitaprost Plus combination drug has antimicrobial and anti-inflammatory properties.
Lomefloxacin is a broad-spectrum bactericidal agent from the group of fluoroquinolones. It affects the bacterial enzyme DNA gyrase, which provides supercoiling, forms a complex with its tetramer (subunit gyrase A2B2) and disrupts transcription and DNA replication, leads to the death of a microbial cell.

Highly active in the world.. Moderately sensitive to the drug Staphylococcus aureus, Staphylococcus Epidermidis, Serratia liquifaciens, Serratia marcescens, Pseudomonas aeruginosa, Mycobacterium tuberculosis, Chlamydia trachomatis, Hafnia alvei, Citrobacter freundii, Aeromonas hydrophila, Proteus mirabilis, Proteus stuartii, Providencia rettgeri, Providencia alcalifaciens, Klebsiella oxytoca, Klebsiella ozaenae, Enterobacter aerogenes, Enterobacter agglomerans. Resistant to the drug Streptococcus spp., Pseudomonas cepacia, Ureaplasma urealyticum, Treponema pallidum, Mycoplasma hominis and anaerobic bacteria. Most microorganisms act in low concentrations (the concentration required to inhibit the growth of 90% of the strains, usually not more than 1 μg / ml). Resistance is rare.

Prostate extract has an organotropic effect on the prostate.Reduces the degree of edema, leukocyte infiltration of the prostate gland, normalizes the secretory function of epithelial cells, increases the number of lecithin grains in the secret of acini, stimulates bladder muscle tone. Reduces thrombosis, has antiplatelet activity, prevents the development of venul thrombosis in the prostate gland. Normalizes the parameters of the prostate and ejaculate. Reduces pain and discomfort, improves copulatory function.

Indications and usage

Acute and chronic bacterial prostatitis caused by susceptible microorganisms (including those accompanied by inflammatory diseases of the urinary tract).
State before and after surgery on the prostate gland.

Contraindications

Children and adolescents up to 18 years (the period of formation and growth of the skeleton).
Hypersensitivity to the drug.

With caution should use the drug for cerebral atherosclerosis, epilepsy and other diseases of the central nervous system with epileptic syndrome.

Pregnancy and Breastfeeding

The drug is not used in women.

The drug should be used rectally in 1 soup. 1 time / day after enema or self-emptying of the intestine.

Before use, the suppository should be removed from the blister pack.After the introduction of the drug, the patient should be in bed for 30-40 minutes.

Treatment is recommended to continue until the pathogen disappears in the prostate secretion: from 10 to 30 days (individually for each patient).

Adverse reactions

Side effects of the drug Vitaprost Plus are associated with the presence of the antibiotic lomefloxacin.

From the side of the central nervous system:Asthenia, dizziness, nervousness, anxiety.

Cardiovascular: Decreased blood pressure, rhythm disturbance, myocardiopathy.

Gastrointestinal: Pseudomembranous enterocolitis, dysbacteriosis, increased activity of hepatic transaminases.

From the hemopoietic system: Bleeding from the digestive tract, thrombocytopenia, increased fibrinolysis, lymphadenopathy.

Allergic reactions:Pruritus, urticaria, photosensitivity, malignant exudative erythema (Stephen-Johnson syndrome).

The substance "Samprost" (prostate extract) rarely causes allergic reactions.

Special notes

When cirrhosis of the liver does not require correction dosing regimen (assuming normal renal function).

During the period of treatment should avoid prolonged exposure to sunlight and the use of artificial UV.

At the first signs of photosensitization (including skin sensitization, burn, hyperemia, edema, blistering, rash, itching, dermatitis), hypersensitivity, manifestations of neurotoxicity (includingexcitement, convulsions, tremor, photophobia, confusion, toxic psychosis, hallucinations) therapy should be discontinued.
Influence on ability to drive motor transport and control mechanisms

During the period of treatment, care must be taken when driving vehicles and engaging in other potentially hazardous activities that require increased concentration and psychomotor reactions.

With simultaneous use increases the activity of oral anticoagulants and increases the toxicity of NSAIDs.

Drugs that block tubular secretion, slow down the excretion of the drug.

There is no cross-resistance with penicillins, cephalosporins, aminoglycosides, co-trimoxazole, Metronidazole.

Storage conditions

The drug should be stored at a temperature not higher than 20 ° C.