Neotone powder for infusion 1000mg №4

Powder for injection

Composition

1 fl. contains phosphocreatine 1 g.

Packing

4 bottles.

Mechanism of action

Neotone - a drug that improves the metabolism of the myocardium and muscle tissue. The chemical structure is similar to macroergic endogenous phosphocreatine. Slows down the process of destruction of the sarcolemma of ischemic cardiomyocytes and myocytes, provides intracellular transport of energy. By improving the microcirculation, the drug reduces the size of the zone of necrosis and ischemia. With ischemia and post-ischemic reperfusion, it causes an antiarrhythmic effect, which is associated with a decrease in the ectopic activity of the ventricles and preservation of the physiological function of cells of Purkinje fibers.

- acute myocardial infarction;
- chronic heart failure;
- intraoperative myocardial ischemia;
- intraoperative limb ischemia;
- acute violation of cerebral circulation;
- in sports medicine: to prevent the development of the syndrome of physical overvoltage and improve adaptation to extreme physical exertion.

Contraindications

Hypersensitivity to the drug.

Pregnancy and Breastfeeding

Data on the safety and efficacy of the drug Neoton during periods of pregnancy and lactation (breastfeeding) are not provided.

Atacute myocardial infarction On the 1st day, 2-4 g of intravenous infusion are administered, followed by drip infusion of 8-16 g in 200 ml of 5% glucose solution for 2 hours. On the 2nd day, 2-4 g of intravenous drip 2 times / day On the 3rd day, 2 g / d drip is prescribed 2 times / day.
If necessary, a course of drug infusion of 2 g 2 times / day can be carried out for 6 days.
Atchronic heart failure administered in / in the drip 1-2 g 2 times / day for 10-14 days.
Atintraoperative myocardial ischemia the drug is administered as part of a conventional cardioplegic solution in the amount of 3 g per 1 liter. Neotone is added to the solution immediately prior to administration. It is recommended to conduct a course of infusion of the drug 2 g 2 times / day for 3-5 days prior to surgery, and for 1-2 days after surgery.
With the possibility of developmentintraoperative limb ischemia It is recommended to introduce 2-4 g of the drug intravenously before the operation, followed by infusion of 8-10 g in a 5% glucose solution during the operation and the reperfusion period.

Adverse reactions

When applied according to indications in recommended doses, no adverse effect was detected.

The drug should be administered as soon as possible after the onset of signs of ischemia, which provides a more favorable prognosis of the disease.
Neotone is not used for emergency correction of disorders of the heart.

Drug Interactions

When used as part of complex therapy, Neoton contributes to the effectiveness of antiarrhythmic, antianginal drugs, as well as drugs that have a positive effect on the myocardial inotropic function.

The drug should be stored at room temperature.