Oxamp sodium powder for injection 500mg bottle №1

Active ingredient and dosage form

Oxamp sodium - powder for solution preparation for on / in / in / in the introduction:

1 fl of powder contains ampicillin sodium 333.33 mg, oxacillin sodium 166.67 mg; in packing of 10 and 50 pieces.

Mechanism of action

Oxamp sodium is a combined antibacterial drug.

Oxacillin is an antibiotic from the group of semi-synthetic penicillins. Bactericidal effect, suppressing the synthesis of the cell wall of bacteria. Resistant to penicillinase. Active against gram-positive bacteria: Staphylococcus spp. (including those producing penicillinase), Streptococcus spp. (including Streptococcus pneumoniae), Corynebacterium diphtheriae, Bacillus anthracis; gram-negative bacteria: Neisseria gonorrhoeae, Neisseria meningitidis; anaerobic bacteria: spore-forming sticks, Actinomyces spp. Most gram-negative bacteria, rickettsia, viruses, protozoa, and fungi are resistant to oxacillin.

Ampicillin is an antibiotic from the group of semi-synthetic penicillins. Bactericidal effect, suppressing the synthesis of the cell wall of bacteria. Active against gram-positive bacteria: Staphylococcus spp. (with the exception of strains producing penicillinase), Streptococcus spp. (including Enterococcus spp.), non-spore-forming bacteria (including Listeria monocytogenes); Gram-negative aerobic bacteria: Neisseria gonorrhoeae, Neisseria meningitidis, Escherichia coli, Shigella spp., Salmonella spp., Bordetella pertussis, some strains of Haemophilus influenzae.

Ampicillin is destroyed by penicillinase.

The combination of ampicillin with oxacillin is rational, becausethe latter, inhibiting the activity of penicillinase, thereby reducing the destruction of ampicillin. The spectrum of action with this combination becomes wider.

Indications and usage

- respiratory tract infections (including bronchitis, pneumonia, bronchiectasis);

- Diseases of the biliary tract (including cholangitis, cholecystitis);

- infections of the urinary tract and kidneys (including pyelitis, pyelonephritis, cystitis);

- infections of the skin and soft tissues (including infected wounds);

- burn disease;

- sore throat.

Prevention of postoperative complications during surgical interventions.

Prevention and treatment of infections in newborns.

Dosage and administration

Oxamp sodium is introduced into the / m or / in (jet or drip).

The single dose for adults is 0.5-1 g, the daily dose is 2-4 g.

Newborns, premature babies and children under the age of 1 year, the drug is prescribed in a daily dose of 100-200 mg / kg body weight; 1-7 years - 100 mg / kg / day; 7-14 years old - 50 mg / kg / day; adolescents over 14 years old are prescribed a dose for adults.

In / in Oxamp sodium is administered for 5-7 days with the subsequent transition (if necessary) to the / m introduction.

Adverse reactions

Allergic reactions: skin rash, urticaria, angioedema; rarely - anaphylactic shock.

Local reactions: with the on / in the introduction of possible development of phlebitis and periphlebitov; when i / m administration - pain at the injection site.

Contraindications

- hypersensitivity to the components of the drug and other antibiotics from the penicillin group.

Pregnancy and Breastfeeding

Perhaps the use of the drug Oxamp sodium in pregnancy if indicated.Excreted in breast milk in low concentrations.

Special notes

If an allergic reaction occurs, it is necessary to stop the administration of oxamp sodium and to conduct desensitization therapy.

Storage conditions

In the dark place at a temperature of no higher than 25 ° C. Shelf life - 2 years.