Logimax retard pills 5mg/47.5mg №30

Mechanism of action

Logimax is a drug that has antiarrhythmic, hypotensive and antianginal effects. When used, Logimax stably and effectively reduces blood pressure within 24 hours, that is, the entire interval between doses. Enhances blood flow in the coronary system, increases the blood supply to the ischemic zones of the myocardium without developing a decrease in the blood supply to the brain areas, activates the functioning of the circulatory pathways of blood, reduces peripheral vascular resistance. It also reduces high blood pressure during physical exertion, at rest and stress.

Indications and usage

Hypertension, symptomatic arterial hypertension.

Contraindications

Hypersensitivity, acute myocardial infarction, unstable stenocardia, severe sinus bradycardia, AV block II-III degree, sick sinus syndrome, severe peripheral circulatory disorders, decompensated heart failure, cardiogenic shock, pregnancy.

Pregnancy and Breastfeeding

Contraindicated in pregnancy. At the time of treatment should stop breastfeeding.

Dosage and Administration

The drug should be taken orally, in the morning, without chewing, drinking water. The initial dose - 1 tab. Once a day, if necessary, double the dose.

There is no need to adjust the treatment regimen in patients with impaired renal function. Usually there is no need to adjust the treatment regimen in patients with impaired liver function, incl. in patients with cirrhosis of the liver. If there are symptoms of severe liver dysfunction (for example, in patients whose history had bypass surgery), the possibility of reducing the dose of the drug should be considered.

In patients of advanced age is usually enough 1 table. Once a day, if necessary - 2 times a day.

Drug interactions

Calcium channel blockers like Verapamil potentiate the negative foreign and chronotropic effect. Enhances negative ino-and dromotropic action of antiarrhythmic drugs (analogs of quinidine, amiodarone), cardiodepressive - inhalation anesthetics Increase the concentration of Metoprolol in plasma cimetidine, hydralazine, alcohol, lowers - rifampicin. Indomethacin and other prostaglandins synthetase inhibitors weaken the hypotensive effect.

Overdosage

Symptoms: hypotension, sinus bradycardia, AV blockade, heart failure, cardiogenic shock, cardiac arrest, bronchospasm, nausea, vomiting, cyanosis. The first signs appear after 20 minutes - 2 hours after administration.

Treatment: induction of vomiting, gastric lavage; symptomatic therapy: in case of severe hypotension, bradycardia or the threat of heart failure - beta1-agonist (IV with an interval of 2–5 min or infusion); either dopamine (iv) or atropine sulfate to block the vagus nerve; dobutamine, norepinephrine, glucagon (1–10 mg). If necessary - the use of a heart rhythm driver. For the relief of bronchospasm - in / in the introduction of beta2-agonist.

Storage conditions

At a temperature not higher than 30 ° C.