Klion D vaginal pills 100mg/100mg №10

Mechanism of action

Combined drug with antimicrobial and antiprotozoal effects for intravaginal use. Metronidazole has antiprotozoan and antibacterial action. Active against Trichomonas vaginalis, Entamoeba histolytica, as well as with respect to obligate anaerobes.
To drug are resistant facultative anaerobes and obligate aerobes.
Miconazole nitrate has antifungal (fungicidal) effect. With intravaginal use active against Candida albicans.

Suction
With intravaginal use, metronidazole undergoes systemic absorption. C_max in blood after intravaginal use is approximately 50% of that C_max, which is achieved after a single dose of an equivalent dose of metronidazole inside.
With intravaginal use of miconazole nitrate is absorbed slightly.
Metabolism
Metronidazole is almost completely metabolized in the liver to form inactive derivatives.
Removal
T_1/2 makes 8 h. Metronidazole is removed mainly with urine.

Indications and usage

- local treatment of vaginal infections caused by Trichomonas vaginalis and / or Candida.

At vaginitis caused by Trichomonas vaginalis, moistened with water 1 pill of the drug is injected deep into the vagina 1 time / day, in the evening before bedtime.The course of treatment is 10 days. At the same time appoint metronidazole inside. With insufficient effectiveness, local treatment is continued for another 10 days.
At candidal vaginitis moistened with water 1 pill of the drug is injected deep into the vagina 1 time / day, in the evening before bedtime. The course of treatment is 10 days.

Adverse reactions

Local reactions: burning, itching, irritation of the mucous membrane of the vagina.
Gastrointestinal: nausea, feeling of bitterness in the mouth, coated tongue, diarrhea, pain in the stomach cramping character.
From the side of the central nervous system: headache, dizziness.
Allergic reactions: hives.
Dermatologic: skin rash.

Contraindications

- I trimester of pregnancy;
- lactation (breastfeeding);
- hypersensitivity to the drug.

Pregnancy and breastfeeding

Klion-D 100 is contraindicated for use in the first trimester of pregnancy.
If necessary, the use of Klion-D 100 during lactation should decide on the termination of breastfeeding.

Special notes

During the period of drug treatment is recommended to refrain from sexual intercourse.
During the period of use of the drug should not drink alcohol.
In the case of vaginitis caused by Trichomonas vaginalis, it is advisable to simultaneously treat the oral partner with oral metronidazole.
Control of laboratory parameters
In the case of the drug in conjunction with metronidazole for oral administration, especially with repeated courses, control of the pattern of peripheral blood is necessary (danger of leukopenia).

Overdosage

Data on drug overdose Klion-D 100 is not provided.

Drug interactions

With simultaneous use of Klion-D 100 and indirect anticoagulants, it is possible to enhance the effect of the latter.

Storage conditions

The drug should be stored in a place protected from light and moisture at a temperature of from 15 ° to 30 ° C.