Sinestrol ampoules 2% 1ml №10

Injection

Composition

1 ampoule with 1 ml of solution for injections in peach oil contains Hexestrol 2 mg.

Packing

10 ampoules

Mechanism of action

Sinestrol has an estrogenic effect. Estrogen is a stilbene derivative, estrogen is equivalent to estrone (the natural follicular hormone necessary for the normal development of the female body). Together with the hormone of the corpus luteum, follicular hormone is involved in the regulation of the menstrual cycle. Estrogens, interacting with specific receptors, affect target organs. Under their action in the fallopian tubes, cervix, vagina, external genital organs, excretory ducts of the mammary glands occurs proliferation of the epithelium. Increases the sensitivity of the muscles of the uterus and fallopian tubes to stimulate their motility drugs. It has a hypolipidemic effect, increases the content of alpha-lipoproteins in the blood and sensitivity to the action of insulin, improves glucose utilization. In large doses, estrogens retain water and Na + in the body, inhibiting erythropoiesis. In large doses it slows down, and in small doses, FSH secretion is activated. Circulation in the blood of large quantities of estrogen for a short time contributes to the ovulatory type of production of LH.Hexestrol facilitates the course of pathologically flowing menopause in women, prevents the development of postmenopausal osteoporosis, eliminates common disorders that occur in the body of women because of ovarian hypofunction after gynecological operations.

Indications and usage

Ovarian hypofunction, amenorrhea, infertility, menopausal disorders in women, prostate adenoma, prostate and breast cancer.

Contraindications

hypersensitivity, pregnancy, estrogen-dependent malignant neoplasms or suspicion of them, unusual or undiagnosed genital or uterine bleeding, thrombophlebitis or thromboembolic diseases in the active phase (except for the treatment of breast and prostate cancer).C caution. Thrombophlebitis, thrombosis or thromboembolism (against the background of estrogen in history); familial hyperlipoproteinemia, pancreatitis, endometriosis, history of gallbladder diseases (especially cholelithiasis), severe hepatic failure, jaundice (including a history of previous pregnancy), hepatic porphyria, leiomyoma, hypercalcemia, associated with bone marrow, in case of bone marrow, heart failure, chromosomal obesity, hemorrhoids, hemorrhoids. Only for the treatment of breast and prostate cancer: diseases of the coronary or cerebral vessels, active thrombophlebitis or thromboembolic diseases (high doses of estrogen used for treatment, increase the risk of myocardial infarction, pulmonary thromboembolism, thrombophlebitis).

Dosage and administration

Sinestrol enter in / m.Doses are set individually depending on the diagnosis. As a rule, for 0.5-5 ml of 2% solution once a day for a month. The highest single dose in the treatment of malignant tumors - 0.06 g (3 ml - 2% p-ra), the highest daily dose - 0.1 g (5 ml - 2% p-ra).

Adverse reactions

In women: pain, sensitivity and increase in the size of the mammary glands, amenorrhea, bleeding "breakthrough", menorrhagia, intermenstrual "smearing" vaginal discharge, breast swelling, increased libido. In men, tenderness and sensitivity of the mammary glands, gynecomastia, decreased libido. Peripheral edema, obstruction of the gallbladder, hepatitis, pancreatitis. Intestinal or biliary colic, flatulence, anorexia, nausea, diarrhea, dizziness, headache (including migraine), intolerance to contact lenses, vomiting (mainly central genesis, mainly in the appointment of large doses). In the treatment of breast and prostate cancer (optional): thromboembolism, thrombosis.

Drug Interactions

Anti-estrogen drugs (clomiphene, etc.) used to treat infertility can block estrogen receptors and weaken the effect of estrogens. Folic acid and thyroid preparations increase the effect of hexestrol. Hexestrol increases the effectiveness of hypolipidemic and antiarrhythmic drugs; weakens the effects of male sex hormones, diuretics and anticoagulants.

Storage conditions

In a dry, dark place at a temperature of no higher than 20 ° C.

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