Angelica pills 2 mg №28

Anti-menopausal agent (estrogen + progestogen).

Indications and usage

HRT for menopausal disorders in the post-menopausal period, including vasomotor symptoms (such as hot flashes, increased sweating), sleep disturbances, depressive states, irritability, involutional changes of the skin and urinary tract, in women with an uterine lump. Prevention of postmenopausal osteoporosis.

Adverse reactions

From the reproductive system: "breakthrough" uterine bleeding and spotting (usually stopped during therapy), a change in the nature of vaginal discharge, an increase in the size of fibroids, a condition similar to premenstrual syndrome; soreness, tension and / or enlargement of the mammary glands, benign lesions of the mammary glands.
Gastrointestinal: dyspepsia, bloating, nausea, vomiting, abdominal pain, relapse of cholestatic jaundice.
From the skin: skin rash, pruritus, chloasma, erythema nodosum, erythema multiforme.
From the side of the central nervous system: headache, migraine, dizziness, emotional lability, anxiety, increased nervous irritability, increased fatigue, insomnia.

Contraindications

• Hypersensitivity;
• vaginal bleeding of unknown origin;
• established or suspected breast cancer;
• established or suspected hormone-dependent precancerous diseases or hormone-dependent malignant tumors, benign or malignant liver tumors (including a history of);
• severe liver disease;
• severe kidney disease, incl. in history (to normalize indicators of renal function);
• acute arterial thrombosis or thromboembolism (including myocardial infarction, stroke);
• deep vein thrombosis in st. aggravations;
• venous thromboembolism (including in history);
• severe hypertriglyceridemia;
• pregnancy;
• lactation period.

Treatment should be discontinued immediately if symptoms of thrombotic disorders appear or if they are suspected.

Special notes

Angelica is not used for contraception. If contraception is necessary, non-hormonal methods should be used (except for calendar and temperature methods). If you suspect a pregnancy, you should stop taking until pregnancy is excluded. Before starting or resuming HRT, a woman is recommended to undergo a thorough general medical and gynecological examination (including breast examination and cytological examination of cervical mucus), to exclude pregnancy. In addition, violations of the blood coagulation system should be excluded. Periodic control tests should be carried out. Acceptance of sex steroids can affect the biochemical indicators of liver, thyroid, adrenal and kidney function, the content of transport proteins such as globulin, sex hormone and lipid / lipoprotein fractions, carbohydrate metabolism, coagulation and fibrinolysis. Angelica does not adversely affect glucose tolerance.

Dosage and administration

Inside If a woman does not take estrogen or goes on Angelique with another combination drug for continuous use, she can begin treatment at any time. Patients who switch to Angelique with the combined drug for cyclic HRT, should begin taking after the end of withdrawal bleeding. Each package is designed for a 28-day reception. Take one pill daily. After the end of taking 28 pills from the current packaging, the next day, begin a new packaging. Angelique (continuous HRT), taking the first pill on the same day of the week as the first pill from the previous package. A pill is swallowed whole with a small amount of liquid. The time of day when a woman takes the drug does not matter, however, if she started taking pills at any particular time, she should stick to that time and beyond. The forgotten pill must be drunk as soon as possible. If more than 24 hours have elapsed after the usual reception time, an additional pill should not be taken. If you skip a few pills, vaginal bleeding may develop.

Overdosage

Studies of acute toxicity did not reveal the risk of acute side effects if you accidentally take the drug in an amount that exceeds many times the daily therapeutic dose. Symptoms that may occur with an overdose: nausea, vomiting, vaginal bleeding. There is no specific antidote, the treatment is symptomatic.

Storage conditions

At room temperature no higher than 25 ° C, 5 years